Karotis Arter Intima-Media Kalınlığının Tahmininde Monosit-HDL Oranı

Abstract

Amaç: Bu çalışmada, artmış monosit sayısının yüksek yoğunluklu lipoprotein düzeylerine oranı (MHO)’nun artmış karotis intima-media kalınlığı (İMK)’yi yordayıp yordamayacağını belirlemeyi amaçladık.
Materyal ve Metot:Kurumumuzun kardiyoloji polikliniğine ayaktan başvuran ardışık tüm olgular bu kesitsel çalışmaya alındı. Kardiyovasküler ve enflamatuar hastalıkları olan olgular hariç tutuldu. Olgular karotis İMK’ye göre iki gruba ayrıldı: karotis İMK>0,9 mm (artmış) ve karotis İMK≤0.9 mm (normal) olanlar. MHO’daki iki grup arasındaki fark, çalışmanın birincil sonuç ölçütüdür.
Bulgular: Artmış İMK’ye sahip olguların MHO’su, normal İMK’ye sahip olgulardan anlamlı olarak daha yüksekti (16,7 ± 5,7’ye karşı 12,8 ± 5,5; p<0,001). Lojistik regresyon analizi, yaşın (OR: 1,202, 95% CI: 1,126-1,284; p<0,001) ve MHR (OR: 1,190, 95% CI: 1,097-1,291; p<0,001)’nin >0,9 mm’lik bir karotis İMK’si için önemli prediktörler olduğunu gösterdi. ROC eğrisi analizi, %72 duyarlılık ve %60,7 özgüllük ile 13,4’lük bir MHO kesme değerinin artmış İMK’nin saptanmasında kullanılabileceğini gösterdi.
Sonuç: Enflamasyon belirteci MHO, subklinik aterosklerozun göstergesi olarak kabul edilen artmış karotis İMK’sini tahmin etmek için basit ve maliyet-etkin bir belirteç olarak kullanılabilir.

Keywords

• Koroner arter hastalığı
• monositler
• yüksek yoğunluklu lipoprotein
• HDL
• karotis intima-media kalınlığı

Monocyte to HDL Ratio in The Prediction of Carotid Artery Intima-Media Thickness

Abstract

Aim: In this study, we aimed to determine whether an increased monocyte count to high-density lipoprotein (MHR) would predict increased carotid intima-media thickness (IMT).
Material and Method: All consecutive subjects presenting to the cardiology outpatient clinic of our institute were enrolled in this cross-sectional study. Subjects with cardiovascular and inflammatory diseases were excluded. Subjects were divided into two groups according to carotid IMT: those with carotid IMT >0.9 mm (increased) and those with carotid IMT ≤0.9 mm (normal). The difference in MHR between the two groups was the primary outcome measure of the study.
Results: The MHR of the subjects with increased IMT was significantly higher than that of subjects with normal IMT (16.7 ± 5.7 vs. 12.8 ± 5.5, p <0.001). Logistic regression analysis demonstrated that age (OR: 1.202, 95% CI: 1.126-1.284, p<0.001) and MHR (OR: 1.190, 95% CI: 1.097-1.291, p<0.001) were significant predictors for a carotid IMT of >0.9 mm. ROC curve analysis revealed an MHR value of 13.4 as a cut-off in the identification of subjects that had increased IMT, with a sensitivity of 72% and specificity of 60.7%.
Conclusion: The inflammation marker MHR can be used as a simple and cost-effective marker to predict increased carotid IMT which is accepted as the indicator of subclinical atherosclerosis.

Keywords

• Coronary artery disease, monocytes
• high‐density lipoprotein
• HDL
• carotid intima-media thickness

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