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Aim: Endotoxins (lipopolysaccharides, LPS) negatively affect reproduction by decreasing gonadotropin levels in the acute period. The aim of this study is to investigate the long-term effects of re-injection of endotoxin in adulthood on gonadotropin release and testicular tissue in male rats injected with endotoxin with IL-1 beta inhibitor (Q-Vd-OPh; caspase-1 inhibitor, Cİ) in the neonatal period.
Material and Methods: On postnatal day 7, male rat pups were injected once with either Salin, LPS (50µg/kg), LPS (50µg/kg)+CI (1mg/kg). On postnatal 10 months, these rats were either injected with saline or LPS (50 µg/kg). 10 days after these injections, serum samples and testicular tissues were taken and the experiment was terminated.
Results: Respectively, control, Salin+LPS, LPS+Salin; LPS+LPS; LPS(CI)+Salin and LPS(CI)+LPS groups were 18.8±1.6; 11.3±1.2; 23.4±2.0; 22.2±1.2 ve 23.6±1.4 ng/ml for serum LH concentrations (p<0,05); while 33.4±2.5; 29.6±1.4; 32.1,6±2.0 28.7 0.8 and 35.5±3.3 ng/ml for FSH concentrations (p>0,05). Seminiferous tubule damage was observed in LPS groups (p<0,05).
Conclusion: This research demonstrates (1) neonatal LPS injections do not negatively affect gonadotropin release in the long term, (2) IL-1 β plays a critical role in the programming of reproduction, especially in terms of testicular histology.
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Primary Language | English |
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Subjects | Clinical Sciences |
Journal Section | Original Articles |
Authors | |
Project Number | Yok |
Publication Date | January 23, 2021 |
Acceptance Date | November 10, 2020 |
Published in Issue | Year 2021 Volume: 3 Issue: 1 |
Chief Editors
Assoc. Prof. Zülal Öner
İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye
Assoc. Prof. Deniz Şenol
Düzce University, Department of Anatomy, Düzce, Türkiye
Editors
Assoc. Prof. Serkan Öner
İzmir Bakırçay University, Department of Radiology, İzmir, Türkiye
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