Clinical Research
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Year 2022, Volume: 4 Issue: 1, 16 - 20, 01.01.2022
https://doi.org/10.37990/medr.944806

Abstract

References

  • 1- Nadler RB, Humphrey PA, Smith DS, et al. Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J Urol 1995; 154:407
  • 2- Dalton DL. Elevated serum prostate-specific antigen due to acute bacterial prostatitis. Urology 1989; 33:465
  • 3- Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol 2017;4:618-629
  • 4- Cihan YB, Arslan A, Ergul MA. Subtypes of White blood cells in patients with prostate cancer or benign prostatic hyperplasia and healthy individuals. AsianPac J CancerPrev. 2013;14(8):4779-83

Role of Platelet Mass Index in the Differential Diagnosis of Patients with Elevated Prostate-Specific Antigen Levels

Year 2022, Volume: 4 Issue: 1, 16 - 20, 01.01.2022
https://doi.org/10.37990/medr.944806

Abstract

Aim: To evaluate the role of platelet mass index (PMI) calculated using hemogram parameters obtained from a routine blood test in the differentiation of prostate cancer in patients with prostate-specific antigen (PSA) values of 2.5-10 ng/dl.
Material and Method: Seventy-five patients with prostate cancer and 48 with prostatitis were included in the study and grouped according to their pathology results. The white blood cell (WBC), hemoglobin (HGB), thrombocyte (PLT), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV) and PMI values were compared between the two groups.
Results: The PMI and PLT levels of the prostate cancer group were statistically significantly lower than those of the prostatitis group (p<0.05). In predicting prostate cancer, the cut-off value for the PMI level was determined as 1.480, at which the likelihood ratio was calculated as 1.08.
Conclusion: We consider that PMI calculated using hemogram parameters in patients with a PSA value below 10 ng/dl will guide the clinician in differentiating prostate cancer from other prostate pathologies without performing an unnecessary biopsy.

References

  • 1- Nadler RB, Humphrey PA, Smith DS, et al. Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels. J Urol 1995; 154:407
  • 2- Dalton DL. Elevated serum prostate-specific antigen due to acute bacterial prostatitis. Urology 1989; 33:465
  • 3- Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. Eur Urol 2017;4:618-629
  • 4- Cihan YB, Arslan A, Ergul MA. Subtypes of White blood cells in patients with prostate cancer or benign prostatic hyperplasia and healthy individuals. AsianPac J CancerPrev. 2013;14(8):4779-83
There are 4 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Original Articles
Authors

Halil Ferat Öncel 0000-0003-4043-5597

Remzi Salar 0000-0002-5078-9367

Engin Özbay 0000-0001-7102-3064

Emine Zeynep Tarini 0000-0001-9874-5104

Publication Date January 1, 2022
Acceptance Date October 11, 2021
Published in Issue Year 2022 Volume: 4 Issue: 1

Cite

AMA Öncel HF, Salar R, Özbay E, Tarini EZ. Role of Platelet Mass Index in the Differential Diagnosis of Patients with Elevated Prostate-Specific Antigen Levels. Med Records. January 2022;4(1):16-20. doi:10.37990/medr.944806

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Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

E-mail: medrecsjournal@gmail.com

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