Vitamin D, VDR, and VDBP Levels Correlate with Anti-inflammatory Cytokine Profile in FMS Patients

Year 2023, Volume: 5 Issue: 1, 24 - 8, 15.01.2023

Pınar Ellergezen , Alev Alp , Sinan Çavun

https://doi.org/10.37990/medr.1131305

Cited By: 1

Abstract

Aim: The major target of this research is to examine whether there is any connection between the levels of vitamin D and anti-inflammatory mediators in patients with fibromyalgia syndrome (FMS).
Materials and Methods: The study contains 30 FMS diagnosed and 25 healthy female individuals and the determination of FMS was made according to the standards of 2010 American College of Rheumatology (ACR). Vitamin D, vitamin D receptor (VDR), vitamin D binding protein (VDBP) levels, and anti-inflammatory cytokine (IL-4, IL-10, TGF-β) levels in the serum of patients with FMS and healthy individuals were measured using enzyme-linked immunosorbent assay (ELISA).
Results: The concentrations of vitamin D, VDR, and VDBP were determined to be higher in healthy controls than in patients with FMS (p<0.001). Correlating with this, IL-4, IL-10, and TGF-β levels were measured remarkably higher in the healthy group than in the FMS patients (p<0.001).
Conclusion: Low vitamin D levels may cause a decrease in anti-inflammatory cytokine levels and their immunosuppressive effect in FMS.

Keywords

anti-inflammatory cytokines, vitamin D, fibromyalgia syndrome

Supporting Institution

Uludağ Üniversitesi Bilimsel Araştırma ve Proje Birimi

Project Number

KUAP (T) 2020/2

Thanks

We would like to thank all the volunteers who participated in this study and the medical pharmacology department for supporting the laboratory studies.

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