Research Article
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Year 2023, Volume: 5 Issue: 1, 73 - 8, 15.01.2023
https://doi.org/10.37990/medr.1162758

Abstract

Supporting Institution

Erciyes Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

TYL-2017-6889

References

  • 1. Aris A, Paris K. Hypothetical link between endometriosis and xenobiotics-associated genetically modified food. Gynecol Obstet Fertil. 2010;38:747-53.
  • 2. Beneke R, Leithauser RM, Ochentel O. Blood lactate diagnostics in exercise testing and training. Int J Sport Physiol Perform. 201;6:8–24.
  • 3. Beneke R, LR and HM. Dependence of the maximal lactate steady state on the motor pattern of exercise. Br J Sports Med. 2001;35:192–6.
  • 4. Borniger JC, Chaudhry A, Muehlenbein MP. Relationships among musical aptitude, digit ratio and testosterone in men and women. PloS One. 2013;8:e57637.
  • 5. Brownlee KK, Moore AW, Hackney AC. Relationship between circulating cortisol and testosterone: influence of physical exercise. J Sports Sci Med. 2005;4:76-83.
  • 6. Costa-Font J, Mossialos E. Are Perceptions of Risk and Benefits of Genetically Modified Food in Dependent? Food Quality and Preference. 2007;18:173-82.
  • 7. D’Agnolo G. GMO: human health risk assessment. Vet Res Commun. 2005;29:7-11.
  • 8. Deminice R, Jordao AA. Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats. Amino Acids. 2012;43:709–15.
  • 9. Domonkos E, Borbélyová V, Csongová M, et al. Sex differences and sex hormones in anxiety-like behavior of aging rats. Horm Behav. 2017;93:159-65.
  • 10. Enns DL, Tiidus PM. The influence of estrogen on skeletal muscle: sex matters. Sports Med. 2010;40:41-58.
  • 11. Gök MŞ. Effect of Different Auditory Stimuli on Vital Signs, Oxygen Saturation and Coma Level of Intensive Care Patients. PhD thesis, Atatürk University, Erzurum, 2015.
  • 12. Fukui H, Kumiko Toyoshima. Music facilitate the neurogenesis, regeneration and repair of neurons. Medical Hypotheses. 2008;71:765-9.
  • 13. Doi H, Basadonne I, Venuti P, et al. Negative correlation between salivary testosterone concentration and preference for sophisticated music in males. Personality and Individual Differences. 2018;125:106-11.
  • 14. Hug K. Genetically modified organisms: do the benefits outweigh the risks? Medicina (Kaunas). 2008;44:87-99.
  • 15. Karakuşlu S. Investigation of Potential Effects of Genetically Modified (GMO) Corn (Zea Mays L.) in Swiss Albino Mice. Master thesis, Giresun University, Giresun, 2014.
  • 16. Kreutz G, Murcia CQ, Bongard S. Psycho neuroendocrine research on music and health: an overview. Music Health And Wellbeing. 2012;30:457-6.
  • 17. Kulaç İ, Ağırdil Y, Yakın M. The Sweet Trouble on Our Tables Genetically Modified Organisms and Their Effects on Public Health. Turkish Journal of Biochemistry. 2006;31:151-5.
  • 18. Mingxia Gao, Bin Li, Wenzhen Yuan, et al. Hypothetical link between infertility and genetically modified food. Recent Pat Food Nutr Agric. 2014;6:16-22.
  • 19. The Effect of Magnesium on Leptin and Triglyceride Levels in Fatty-Feeded Mice. Journal of Erciyes University Faculty of Veterinary Medicine. 2017;14:31-37.
  • 20. Niemiro GM, Rewane A, Algotar AM. Exercise and Fitness Effect On Obesity. [Updated 2022 Jun 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539893/
  • 21. Özer I. Genetically Modified Foods and Their Effects on Human Health. Clinical pediatrics. 2003;2:74-7.
  • 22. Pamuk Ş. A General Approach to Genetically Modified Foods. Kocatepe Vet J. 2010;3:91-100.
  • 23. Paparini A. Romano-Spica V. Public health issues related with the consumption of food obtained from genetically modified organisms. Biotechnol Annu Rev. 2004;10:85-122.
  • 24. Pusztai A, Bardocz S, Ewen SWB. Genetically Modified Foods: Potential Human Health Effects. In: D’Mello JPF, ed. Food Safety: Contaminants and Toxin. UK:CAB International, Wallingford Oxon. 2003;16:347-72.
  • 25. Lee S, Lee N, Dockter CE. Effects of Message Presentation Type on GM Food Risk Perception, Similarity Judgment and Attitude. Health Communication. 2021;36:1666-76.
  • 26. Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, et al. Long term toxicity of a roundup herbicide and a rounduptolerant genetically modified maize. Food Chem Toxicol. 2012;50:4221-31.
  • 27. Séralini G, Moslemi S. Aromatase inhibitors: Past, present and future. Mol Cell Endocrinol. 2001;178:117-31.
  • 28. Tyshko NV, Zhminchenko VM, Pashorina VA. Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations. Vopr Pitan. 2011;80:14-28.
  • 29. Voltarelli FA, Gobatto CA, de Mello MAR. Determination of anaerobic threshold in rats using the lactate minimum test. Brazilian J Med Biol Res. 2002;35:1389–94.
  • 30. Woodward A, Klonizakis M, Broom D. Exercise and Polycystic Ovary Syndrome. Adv Exp Med Biol. 2020;1228:123-36.
  • 31. Zhou XH, Dong Y, Wang Y, et al. A threegeneration study with high-lysine transgenic rice in Sprague Dawley rats. Food Chem Toxicol. 2012;50:1902-10.
  • 32. https://t24.com.tr/haber/testosteron-seviyesi-muzik-tercihlerini-belirliyor,541641 access date 17.11.18
  • 33. http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml access date 10.08.2015
  • 34. http://ekolojikolektifi.org/wp-content/uploads/2017/11/GDO_08-10-SorudaGenetiği-Değiştirilmiş-Organizmalar_01.pdf access date 17.11.18.

Effects of Auditory Stimulation and Exercise on Gender Hormones in GMOs-Fed Rats

Year 2023, Volume: 5 Issue: 1, 73 - 8, 15.01.2023
https://doi.org/10.37990/medr.1162758

Abstract

Aim: In this study, it was aimed to investigate the effects of auditory stimuli and exercise on structural measurements, functional characteristics and sex hormones of rats fed with genetically modified organisms (GMO).
Materials and Methods: A total of 64 8-week-old Spraque Dawley rats, 32 male and 32 female, were used in the study. GMO feeding, auditory stimulus and exercise were applied to both male and female rats. Control groups were also formed at the same time as the experimental groups. GMO application; It was fed by mixing 20ml water+20ml corn syrup per day. Auditory application; Segah and Hüseyni maqams were played at 55 decibels loudness for 60 minutes a day. Exercise app; It was applied as challenging swimming in an 80 cm long and 40 cm wide pool.
Results: It was determined that the body weights of all rats treated with GMO showed a significant increase (p<0.05). Significant increases in blood lactate levels were observed in exercise-treated rats (p<0.05). It was determined that musical auditory stimuli were effective on sex hormones and significant decreases occurred in estrogen levels of female rats fed GMOs (p<0.05).
Conclusion: It was observed that the preference of feeding with GMO significantly affected the body composition of the subjects. It was determined that swimming and sound stimuli were effective on sex hormones. It was determined that there was an increase in testosterone levels in male rats fed with exercise and GMO. A significant decrease was determined in the estrogen levels of female rats, especially in those fed with GMOs. For this reason, it was seen that the changes in the sex hormones caused by the high fructose-containing GMO diet can cause very important health problems. It was determined that more research on the subject should be done in order to explain the system response mechanisms of the organism, the relationship between exercise and auditory stimuli and GMO nutrition.

Project Number

TYL-2017-6889

References

  • 1. Aris A, Paris K. Hypothetical link between endometriosis and xenobiotics-associated genetically modified food. Gynecol Obstet Fertil. 2010;38:747-53.
  • 2. Beneke R, Leithauser RM, Ochentel O. Blood lactate diagnostics in exercise testing and training. Int J Sport Physiol Perform. 201;6:8–24.
  • 3. Beneke R, LR and HM. Dependence of the maximal lactate steady state on the motor pattern of exercise. Br J Sports Med. 2001;35:192–6.
  • 4. Borniger JC, Chaudhry A, Muehlenbein MP. Relationships among musical aptitude, digit ratio and testosterone in men and women. PloS One. 2013;8:e57637.
  • 5. Brownlee KK, Moore AW, Hackney AC. Relationship between circulating cortisol and testosterone: influence of physical exercise. J Sports Sci Med. 2005;4:76-83.
  • 6. Costa-Font J, Mossialos E. Are Perceptions of Risk and Benefits of Genetically Modified Food in Dependent? Food Quality and Preference. 2007;18:173-82.
  • 7. D’Agnolo G. GMO: human health risk assessment. Vet Res Commun. 2005;29:7-11.
  • 8. Deminice R, Jordao AA. Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats. Amino Acids. 2012;43:709–15.
  • 9. Domonkos E, Borbélyová V, Csongová M, et al. Sex differences and sex hormones in anxiety-like behavior of aging rats. Horm Behav. 2017;93:159-65.
  • 10. Enns DL, Tiidus PM. The influence of estrogen on skeletal muscle: sex matters. Sports Med. 2010;40:41-58.
  • 11. Gök MŞ. Effect of Different Auditory Stimuli on Vital Signs, Oxygen Saturation and Coma Level of Intensive Care Patients. PhD thesis, Atatürk University, Erzurum, 2015.
  • 12. Fukui H, Kumiko Toyoshima. Music facilitate the neurogenesis, regeneration and repair of neurons. Medical Hypotheses. 2008;71:765-9.
  • 13. Doi H, Basadonne I, Venuti P, et al. Negative correlation between salivary testosterone concentration and preference for sophisticated music in males. Personality and Individual Differences. 2018;125:106-11.
  • 14. Hug K. Genetically modified organisms: do the benefits outweigh the risks? Medicina (Kaunas). 2008;44:87-99.
  • 15. Karakuşlu S. Investigation of Potential Effects of Genetically Modified (GMO) Corn (Zea Mays L.) in Swiss Albino Mice. Master thesis, Giresun University, Giresun, 2014.
  • 16. Kreutz G, Murcia CQ, Bongard S. Psycho neuroendocrine research on music and health: an overview. Music Health And Wellbeing. 2012;30:457-6.
  • 17. Kulaç İ, Ağırdil Y, Yakın M. The Sweet Trouble on Our Tables Genetically Modified Organisms and Their Effects on Public Health. Turkish Journal of Biochemistry. 2006;31:151-5.
  • 18. Mingxia Gao, Bin Li, Wenzhen Yuan, et al. Hypothetical link between infertility and genetically modified food. Recent Pat Food Nutr Agric. 2014;6:16-22.
  • 19. The Effect of Magnesium on Leptin and Triglyceride Levels in Fatty-Feeded Mice. Journal of Erciyes University Faculty of Veterinary Medicine. 2017;14:31-37.
  • 20. Niemiro GM, Rewane A, Algotar AM. Exercise and Fitness Effect On Obesity. [Updated 2022 Jun 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539893/
  • 21. Özer I. Genetically Modified Foods and Their Effects on Human Health. Clinical pediatrics. 2003;2:74-7.
  • 22. Pamuk Ş. A General Approach to Genetically Modified Foods. Kocatepe Vet J. 2010;3:91-100.
  • 23. Paparini A. Romano-Spica V. Public health issues related with the consumption of food obtained from genetically modified organisms. Biotechnol Annu Rev. 2004;10:85-122.
  • 24. Pusztai A, Bardocz S, Ewen SWB. Genetically Modified Foods: Potential Human Health Effects. In: D’Mello JPF, ed. Food Safety: Contaminants and Toxin. UK:CAB International, Wallingford Oxon. 2003;16:347-72.
  • 25. Lee S, Lee N, Dockter CE. Effects of Message Presentation Type on GM Food Risk Perception, Similarity Judgment and Attitude. Health Communication. 2021;36:1666-76.
  • 26. Séralini GE, Clair E, Mesnage R, Gress S, Defarge N, Malatesta M, et al. Long term toxicity of a roundup herbicide and a rounduptolerant genetically modified maize. Food Chem Toxicol. 2012;50:4221-31.
  • 27. Séralini G, Moslemi S. Aromatase inhibitors: Past, present and future. Mol Cell Endocrinol. 2001;178:117-31.
  • 28. Tyshko NV, Zhminchenko VM, Pashorina VA. Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations. Vopr Pitan. 2011;80:14-28.
  • 29. Voltarelli FA, Gobatto CA, de Mello MAR. Determination of anaerobic threshold in rats using the lactate minimum test. Brazilian J Med Biol Res. 2002;35:1389–94.
  • 30. Woodward A, Klonizakis M, Broom D. Exercise and Polycystic Ovary Syndrome. Adv Exp Med Biol. 2020;1228:123-36.
  • 31. Zhou XH, Dong Y, Wang Y, et al. A threegeneration study with high-lysine transgenic rice in Sprague Dawley rats. Food Chem Toxicol. 2012;50:1902-10.
  • 32. https://t24.com.tr/haber/testosteron-seviyesi-muzik-tercihlerini-belirliyor,541641 access date 17.11.18
  • 33. http://www.ornl.gov/sci/techresources/Human_Genome/elsi/gmfood.shtml access date 10.08.2015
  • 34. http://ekolojikolektifi.org/wp-content/uploads/2017/11/GDO_08-10-SorudaGenetiği-Değiştirilmiş-Organizmalar_01.pdf access date 17.11.18.
There are 34 citations in total.

Details

Primary Language English
Subjects Clinical Sciences, ​Internal Diseases
Journal Section Original Articles
Authors

Ali Bozkurt 0000-0003-1287-1498

Bekir Çoksevim 0000-0002-8637-071X

Özlem Bozkurt 0000-0002-8455-4275

Işınsu Alkan 0000-0002-9819-7766

Merve Yürük 0000-0003-3295-5322

Project Number TYL-2017-6889
Early Pub Date January 15, 2023
Publication Date January 15, 2023
Acceptance Date October 2, 2022
Published in Issue Year 2023 Volume: 5 Issue: 1

Cite

AMA Bozkurt A, Çoksevim B, Bozkurt Ö, Alkan I, Yürük M. Effects of Auditory Stimulation and Exercise on Gender Hormones in GMOs-Fed Rats. Med Records. January 2023;5(1):73-8. doi:10.37990/medr.1162758

17741

Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

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