Relation of Immune Thrombocytopenia and Blood Group: A Retrospective Single Center Study

Year 2023, Volume: 5 Issue: Supplement (1) - Innovations in Medicine and Healthcare in the 100th Year of the Republic, 65 - 8, 19.10.2023

Cem Selim , İrfan Yavaş , Ali Bolaman

https://doi.org/10.37990/medr.1327379

Abstract

Aim: Although blood group antigens were initially identified as erythrocyte surface antigens and their significance was mainly ascribed to serology, it soon became evident that these antigens are widely distributed in human tissues such as platelets. Immunthrombocytopenia (ITP) is a common autoimmune disorder characterized by a low platelet count. In our study, we investigated the relationship between ABO and Rhesus (Rh) blood groups and primary ITP.
Material and Methods: A retrospective study was conducted at our center with 304 patients diagnosed with primary ITP and 491 blood donors.
Results: ABO phenotype in patients group A, B, O, AB were 42.8%, 14.1%, 34.9%, 8.2%, respectively and 51.6%, 8.1%, 27.9%, 12.4% in the control group, respectively. Rh phenotype in patients group positive or negative 87.5%, 12.5 % respectively and 88.8%, 11.2% in the control group, respectively. A total of 304 patients with primary ITP, consisting of 203 (66.8%) females, and 101(33,2%) males were included in this study. The mean age was 49,5 ±18 years. There was no significant difference in the distribution of ABO blood types and Rh factor by gender (respectively p=0.176, p= 0.195).
Conclusion: In our study, no significant difference was found between the blood group distribution in the population and the blood group distribution of patients diagnosed with primary ITP.

Keywords

Blood groups , Immunthrombocytopenia , Thrombocytopenia , Splenectomy

References

• Storry JR, Castilho L, Daniels G, et al. International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology: Cancun report 2012. Vox Sang. 2014;107:90-6.
• Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115:4635-43.
• MAhamad S, Modi D, Al-Samkari, et al. Proceedings of the immune thrombocytopenia (itp) summit: new concepts in mechanisms, diagnosis, and management. Res Pract Thromb Haemost. 2023;7:100097.
• X Xu, F Xu, Y Ying, et al.ABO antigen levels on platelets of normal and variant ABO blood group individuals. Platelets. 2019;30:854-60.
• Peterson JA, McFarland JG, Curtis BR, Aster RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol. 2013;161:3-14.
• Cooling LLW, Zhang D, Koerner T. Human platelets express gangliosides with LKE activity and ABH blood group activity. Transfusion. 2001;41:504-16.
• Hiltunen LM, Laivuori H, Rautanen A, al. Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study. Thromb Res. 2009;124:167-73.
• El-Khateeb MS, Awidi AS, Tarawneh MS, Abu-Khalaf M. HLA antigens, blood groups and immunoglobulin levels in idiopathic thrombocytopenic purpura. Acta Haematol. 1986;76:110-4.
• Sturgill MG, Nagabandi SR, Drachtman RA, et al. The effect of ABO and Rh blood type on the response to intravenous immune globulin (IVIG) in children with immune thrombocytopenic purpura (ITP). J Pediatr Hematol Oncol. 1997;19:523-5.
• Hussein E, Teruya J. Evaluating the impact of the ABO blood group on the clinical outcome of thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency. Vox Sang. 2017;112:434-42.
• Ozbay I, Binnetoglu A, Kucur C, et.al. Is blood type really a risk factor for epistaxis?. B-ENT. 2016;12:95-8.
• Tanriverdi O. Is there a predictive significance of ABO blood group on chemotherapy-induced thrombocytopenia in patients with stage III colon cancer?. Medical Oncol. 2015;32:384.
• Kumar S, Mahto N, Bharti A, Meena LP. Hematological malignancies in relation with ABO blood group at a teaching hospital, Varanasi, India. J Family Med Prim Care. 2020;9:2309-12.
• Burd JE, Quist-Nelson JO, Edward SE, et .al. Blood type and postpartum hemorrhage by mode of delivery: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2021;256:348-53.
• Wintrobe MM. Clinical Haematology 14th edition Philadelphia, Lea & Febiger, 2018.
• Akbay T, Demiröz P, Güney Ç, et al. Türkiye’de kan gruplarının coğrafi bölgelere göre dağılımı. GATA Bülteni. 1989;31:391-402.