Is Post-COVID 19 Vaccination Antibody Level Related to Happiness and Stress Hormones?

Year 2024, Volume: 6 Issue: 1, 71 - 75, 31.01.2024

Cihat Uçar , Faruk Dişli , Tuğçe Atçalı , Sedat Yıldız

https://doi.org/10.37990/medr.1394973

Abstract

Aim: The level of antibody production in those vaccinated against coronavirus can be affected by many different situations. There is an important balance between immune response, stress and emotional state. However, it is not known how this situation affects antibody production after vaccination. This study aimed to investigate the correlation between the antibody response induced by the COVID-19 vaccine and the hormones cortisol, a marker of the stress axis, and serotonin, a marker of happiness.
Material and Method: Serum cortisol and serotonin levels were analyzed in those who tested positive (n=40) and negative (n=40) for Anti-SARS CoV-2 IgG induced by vaccination. Anti-SARS CoV 2 IgG, cortisol, and serotonin levels were determined by using the ELISA method. The data were compared using the Mann-Whitney U test. The value of p<0.05 was considered as statistically significant.
Results: Cortisol level (42.2±26.2 ng/ml) and serotonin level (414±246 ng/ml) were determined in subjects who tested positive for Anti-SARS CoV-2 IgG, while cortisol level (45.1±34.5 ng/ml) and serotonin level (372±209 ng/ml) were determined in subjects who tested negative for Anti-SARS CoV-2 IgG. There was no statistical difference or correlation between cortisol and serotonin levels in those with positive and negative levels of Anti-SARS CoV-2 IgG (p>0.05).
Conclusion: Consequently, no effect of the stress parameter cortisol and the happiness parameter serotonin, was found in vaccine-induced immunization. It is considered that the different antibody responses in individuals may vary depending on other factors.

Keywords

COVID 19 Vaccination, Anti-SARS CoV 2 IgG, Cortisol, Serotonin

Supporting Institution

İnönü Üniversitesi Bilimsel Araştırma ve Koordinasyon Birimi

Thanks

Çalışmamızı destekleyen İnönü Üniversitesi Bilimsel Araştırma ve Koordinasyon Birimi'ne teşekkür ederiz

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