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Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?

Year 2024, Volume: 6 Issue: 1, 32 - 36, 31.01.2024
https://doi.org/10.37990/medr.1398279

Abstract

Aim: The relationship between insulin resistance and inflammation and atopy is a matter of curiosity and various studies have been conducted. Study results show differences. We aimed to evaluate the relationship between insulin resistance and inflammation and atopy using C-Reactive Protein (CRP) and Neutrophil to lymphocyte ratio (NLR) as eosinophils and inflammatory indices and to determine whether the low-cost hemogram can be used as a reliable marker.
Material and Method: Between May 2022 and November 2023, 1566 children admitted to the Pediatrics outpatient clinics of İzmir Bakırçay University Çiğli Training and Research Hospital were retrospectively screened. A total of 349 pediatric patients without any known chronic disease and with complete blood count, CRP and HOMA-IR levels were retrospectively included in the study.
Results: Individuals with HOMA-IR<2.5 were considered as control group and those with HOMA-IR≥2.5 were considered as children with insulin resistance. As a result of Mann-Whitney-U test performed according to HOMA-IR groups, age and NLR parameters were found to be higher in the group with insulin resistance. This result was statistically significant (p<0.05). The results were not significant in eosinophil (p=0.324) and CRP (p=0.352) parameters.
Conclusion: NLR value may be a credible predictive marker of insulin resistance. Inexpensive and simple complete blood count measurement may help in the early diagnosis of Type 2 DM and in the design of treatments. In addition, due to the increasing risk of insulin resistance with age, education on conscious nutrition can be given in schools during adolescence.

References

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  • Di Genova L, Penta L, Biscarini A, et al. Children with obesity and asthma: which are the best options for their management?. Nutrients. 2018;10:1634.
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  • Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov.2009;3:73-80.
  • Strunk RC, Colvin R, Bacharier LB, et al. Airway obstruction worsens in young adults with asthma who become obese. J Allergy Clin Immunol Pract. 2015;3:765-71.e2.
  • Nahhas M, Bhopal R, Anandan C, et al. Investigating the association between obesity and asthma in 6- to 8-year-old Saudi children: a matched case–control study. NPJ Prim Care Respir Med. 2014;24:14004.
  • Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome. Arq Bras Cardiol. 2008;90:31-6. Erratum in: Arq Bras Cardiol. 2008;90:309.
  • Von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J Immunol. 2008;181:5183-8.
  • Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-7.
  • Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol. 2008;101:747-52.
  • Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail. 2012;34:155-9.
  • Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract. 2005;69:29-35.
  • Lee SE, Baek JY, Han K, Koh EH. Insulin resistance increases serum immunoglobulin e sensitization in premenopausal women. Diabetes Metab J. 2021;45:175-82.
  • Thuesen BH, Husemoen LL, Hersoug LG, et al. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy. 2009;39:700-7.
  • Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010;65:1455-63.
  • Liying Z, Tingwei S, Min X, et al. Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults. PLoS One. 2013;8:e67613.
  • Cardet JC, Ash S, Kusa T, et al. Insulin resistance modifies the association between obesity and current asthma in adults. Eur Respir J.2016;48:403-10.
  • Tabák AG, Kivimäki M, Brunner EJ, et al. Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death: the Whitehall II study. Eur J Endocrinol. 2010;163:89-95.
  • Meiqin L, Peng L, Ru T, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15:9.
  • Atlı H, Önalan E, Yakar B. The effect of insulin resistance on inflammation markers in individuals with obesity. Medical Science and Discovery. 2021;8:619-22.
  • Karakaya S, Altay M, Efe FK, et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci. 2019;49:245-8.
  • Saricam O. Hematological and inflammatory parameters effective on inflammationand insulin resistance in obesity. KSU Medical Journal. 2023;18:39-44.
  • Bizu G, Luis R, Tania, et al. Association between insulin resistance and c-reactive protein among Peruvian adults. Diabetol Metab Syndr. 2010;2:30.
  • Güneş HK, Gerald R, Steven L. Relationship between insulin resistance and c-reactive protein in a patient population treated with second generation antipsychotic medications. Int Clin Psychopharmacol. 2011;26:43-7.
  • Yang H, Gong R, Liu M, et al. HOMA-IR is positively correlated with biological age and advanced aging in the US adult population. Eur J Med Res. 2023;28:470.
  • Strazhesko I, Tkacheva O, Boytsov S, et al. Association of insulin resistance, arterial stiffness and telomere length in adults free of cardiovascular diseases. PLoS ONE. 2015;10:e0136676.
Year 2024, Volume: 6 Issue: 1, 32 - 36, 31.01.2024
https://doi.org/10.37990/medr.1398279

Abstract

References

  • Lang JE. Exercise, obesity, and asthma in children and adolescents. J Pediatr (Rio J). 2014;90:215-7.
  • Di Genova L, Penta L, Biscarini A, et al. Children with obesity and asthma: which are the best options for their management?. Nutrients. 2018;10:1634.
  • Shoelson S, Lee J, Goldfine A. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793-801. Erratum in: J Clin Invest. 2006;116:2308.
  • Visser M, Bouter LM, McQuillan GM, et al. Low-grade systemic inflammation in overweight children. Pediatrics. 2001;107:E13.
  • Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280:E745-51.
  • Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov.2009;3:73-80.
  • Strunk RC, Colvin R, Bacharier LB, et al. Airway obstruction worsens in young adults with asthma who become obese. J Allergy Clin Immunol Pract. 2015;3:765-71.e2.
  • Nahhas M, Bhopal R, Anandan C, et al. Investigating the association between obesity and asthma in 6- to 8-year-old Saudi children: a matched case–control study. NPJ Prim Care Respir Med. 2014;24:14004.
  • Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome. Arq Bras Cardiol. 2008;90:31-6. Erratum in: Arq Bras Cardiol. 2008;90:309.
  • Von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J Immunol. 2008;181:5183-8.
  • Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-7.
  • Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol. 2008;101:747-52.
  • Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail. 2012;34:155-9.
  • Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract. 2005;69:29-35.
  • Lee SE, Baek JY, Han K, Koh EH. Insulin resistance increases serum immunoglobulin e sensitization in premenopausal women. Diabetes Metab J. 2021;45:175-82.
  • Thuesen BH, Husemoen LL, Hersoug LG, et al. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy. 2009;39:700-7.
  • Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010;65:1455-63.
  • Liying Z, Tingwei S, Min X, et al. Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults. PLoS One. 2013;8:e67613.
  • Cardet JC, Ash S, Kusa T, et al. Insulin resistance modifies the association between obesity and current asthma in adults. Eur Respir J.2016;48:403-10.
  • Tabák AG, Kivimäki M, Brunner EJ, et al. Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death: the Whitehall II study. Eur J Endocrinol. 2010;163:89-95.
  • Meiqin L, Peng L, Ru T, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15:9.
  • Atlı H, Önalan E, Yakar B. The effect of insulin resistance on inflammation markers in individuals with obesity. Medical Science and Discovery. 2021;8:619-22.
  • Karakaya S, Altay M, Efe FK, et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci. 2019;49:245-8.
  • Saricam O. Hematological and inflammatory parameters effective on inflammationand insulin resistance in obesity. KSU Medical Journal. 2023;18:39-44.
  • Bizu G, Luis R, Tania, et al. Association between insulin resistance and c-reactive protein among Peruvian adults. Diabetol Metab Syndr. 2010;2:30.
  • Güneş HK, Gerald R, Steven L. Relationship between insulin resistance and c-reactive protein in a patient population treated with second generation antipsychotic medications. Int Clin Psychopharmacol. 2011;26:43-7.
  • Yang H, Gong R, Liu M, et al. HOMA-IR is positively correlated with biological age and advanced aging in the US adult population. Eur J Med Res. 2023;28:470.
  • Strazhesko I, Tkacheva O, Boytsov S, et al. Association of insulin resistance, arterial stiffness and telomere length in adults free of cardiovascular diseases. PLoS ONE. 2015;10:e0136676.
There are 28 citations in total.

Details

Primary Language English
Subjects Paediatrics (Other)
Journal Section Original Articles
Authors

Meltem Yiğit 0009-0009-8568-3675

Özgür Olukman 0000-0003-4006-0465

Publication Date January 31, 2024
Submission Date November 30, 2023
Acceptance Date December 22, 2023
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

AMA Yiğit M, Olukman Ö. Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?. Med Records. January 2024;6(1):32-36. doi:10.37990/medr.1398279

17741

Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

E-mail: medrecsjournal@gmail.com

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