Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?

Year 2024, Volume: 6 Issue: 1, 32 - 36, 31.01.2024

Meltem Yiğit , Özgür Olukman

https://doi.org/10.37990/medr.1398279

Abstract

Aim: The relationship between insulin resistance and inflammation and atopy is a matter of curiosity and various studies have been conducted. Study results show differences. We aimed to evaluate the relationship between insulin resistance and inflammation and atopy using C-Reactive Protein (CRP) and Neutrophil to lymphocyte ratio (NLR) as eosinophils and inflammatory indices and to determine whether the low-cost hemogram can be used as a reliable marker.
Material and Method: Between May 2022 and November 2023, 1566 children admitted to the Pediatrics outpatient clinics of İzmir Bakırçay University Çiğli Training and Research Hospital were retrospectively screened. A total of 349 pediatric patients without any known chronic disease and with complete blood count, CRP and HOMA-IR levels were retrospectively included in the study.
Results: Individuals with HOMA-IR<2.5 were considered as control group and those with HOMA-IR≥2.5 were considered as children with insulin resistance. As a result of Mann-Whitney-U test performed according to HOMA-IR groups, age and NLR parameters were found to be higher in the group with insulin resistance. This result was statistically significant (p<0.05). The results were not significant in eosinophil (p=0.324) and CRP (p=0.352) parameters.
Conclusion: NLR value may be a credible predictive marker of insulin resistance. Inexpensive and simple complete blood count measurement may help in the early diagnosis of Type 2 DM and in the design of treatments. In addition, due to the increasing risk of insulin resistance with age, education on conscious nutrition can be given in schools during adolescence.

Keywords

Neutrophil-to-lymphocyte ratio, Insulin resistance, Inflammation, eosinophils, CRP

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