Could ELABELA be a Protective Biomarker in Patients with Abnormal Uterine Bleeding?

Year 2024, Volume: 6 Issue: 3, 413 - 418, 24.09.2024

Tuğba Raika Kıran , Umran Karabulut , Önder Otlu , Engin Yıldırım , Mehmet Erdem , Feyza İnceoğlu

https://doi.org/10.37990/medr.1490041

Abstract

Aim: Abnormal uterine bleeding (AUB) is a health problem characterized by various symptoms such as heavy and prolonged menstrual bleeding, affecting approximately 30% of female patients both physiologically and psychologically. The objective of this study was to assess serum Elabela (ELA) concentrations in women aged 18 and above diagnosed with functional AUB, and to compare these concentrations with those of healthy women.
Material and Method: This prospective case-control study was performed from August 18, 2022 to December 30, 2022. This was a cross-sectional study including 50 women who applied to the gynecology service of Malatya Turgut Özal Training and Research Hospital with complaints of AUB and 50 women without AUB who underwent gynecological examination. The presence of AUB in patients was determined based on clinical examination conducted by a gynecologist and medical records. Demographic and clinical characteristics were recorded. Serum ELA levels were determined by commercial ELISA kit.
Results: Serum ELA levels was significantly lower in patients with AUB (581.54±272.25 pg/mL) compared to the healthy group (744.55±300.31 pg/mL, p=0.005). In this study, ELA in patients with AUB showed 98% sensitivity and 80% specificity with a cut off value of 411.41 pg/mL (area under the curve [AUC], 68.1%; p=0.002).
Conclusion: Serum ELA levels in patients with AUB were significantly lower than in healthy women. These results show that ELA is a good predictor of the pathophysiological process of AUB.

Keywords

Elabela, abnormal uterine bleeding, PALM-COEIN

Ethical Statement

This study was approved by the Ethics Committee of Malatya Turgut Özal University Clinical Research Ethics Committee (18.08.2022, Approval No:2022/37).

Supporting Institution

No Support

Project Number

No Project

Thanks

No

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