Could There Be a Relationship Between Paranasal Sinus and Migraine Etiology?

Year 2024, Volume: 6 Issue: 3, 365 - 368

Ahmet Payas , Şule Göktürk , Yasin Göktürk , Ali Koç , Adem Tokpınar , Hikmet Kocaman

https://doi.org/10.37990/medr.1498699

Abstract

Aim: Migraine is a complex neurological disease with a neurogenic inflammatory component in which nitric oxide (NO) levels increase. Studies have shown that the NO level produced in adults is closely related to the paranasal sinus volume. The aim of this study is to investigate the differences in paranasal sinus volumes responsible for NO synthesis in migraine patients.
Material and Method: The paranasal sinuses of migraine patients (n=50) and healthy subjects (n=50) were examined using cranial T1-weighted magnetic resonance images (MRI). Right and left maxillary, sphenoid and frontal-ethmoid sinus volumes of the groups were calculated in 3D Slicer program and recorded in mm3. Statistical analysis of the study was performed with IBM SPSS 23.0 and p<0.05 values were considered significant.
Results: A statistically significant difference was observed between migraine patients and healthy subjects across all sinus volumes, with the sinus volumes of migraine patients being higher than those of healthy subjects (p<0.05).
Conclusion: We think that the fact that the paranasal sinus volume, which is primarily responsible for NO synthesis, was found to be high in migraine patients may be related to the high NO level in migraine patients.

Keywords

Paranasal sinus, nitric oxide, migraine, pain, maxillary sinus

Ethical Statement

Ethics Committee Approval: The Kayseri City Training and Research Hospital Clinical Research Ethics Committee granted approval for this study (15.12.2023/number: 1017).

Supporting Institution

FUNDING This study was not funded by any commissions of the public, commercial, or not-for-profit sectors for the conduct of research, study design, collection, analysis, and interpretation of the data writing the report, and/or decision of the article for publication.

Thanks

No

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