Research Article
BibTex RIS Cite

Year 2025, Volume: 7 Issue: 2, 469 - 475, 09.05.2025
https://doi.org/10.37990/medr.1659469

Abstract

References

  • Lai C-C, Wang C-Y, Wang Y-H, et al. Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status. Int J Antimicrob Agents. 2020;55:105946.
  • WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/ access date: 01.11.2023.
  • Levi M, van der Poll T. Coagulation and sepsis. Thrombosis research. 2017;149:38-44.
  • Schmitt FCF, Manolov V, Morgenstern J, et al. Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study. Ann Intensive Care. 2019;9:19.
  • Gupta N, Zhao Y-Y, Evans CE. The stimulation of thrombosis by hypoxia. Thromb Res. 2019;181:77-83.
  • Terzioğlu K. Use of monocyte/HIGH-density lipoprotein-cholesterol ratio in determining the prognosis of patients presenting to the emergency department with ischemic cerebrovascular disease. Dissertation. Erzurum Atatürk University, 2021.
  • Fırat O, Karakuş M, Arsava E, et al. Comparison of guidelines in risk factor management of ischemic stroke. STED. 2021;30:211-7.
  • Li Y, Li M, Wang M, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5:279-84.
  • Geleris J, Sun Y, Platt J, et al. Observational study of hydroxychloroquine in hospitalized patients with Covid-19. N Engl J Med. 2020;382:2411-8.
  • Nascimento BR, Brant LCC, Marino BC, et al. Implementing myocardial infarction systems of care in low/middle-income countries. Heart. 2019;105:20-6.
  • Karabacak M. Cardiovascular effects of COVID-19 pandemia. SDÜ Tıp Fakültesi Dergisi. 2021;28:229-33.
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62. Erratum in: Lancet. 2020;395:1038. Erratum in: Lancet. 2020;395:1038.
  • Small C, Mehkri Y, Panther E, et al. Coronavirus disease-2019 and stroke: pathophysiology and management. Can J Neurol Sci. 2023;50:495-502.
  • Mitra B, Mitchell RD, Cloud GC, et al. Presentations of stroke and acute myocardial infarction in the first 28 days following the introduction of State of Emergency restrictions for COVID‐19. Emerg Med Australas. 2020;32:1040-5.
  • Uslusoy DK. Retrospective analysis of the effects of the COVID-19 pandemic process on patients admitted to the emergency department with a diagnosis of cerebrovascular disease. Dissertation. Bursa Uludağ University, 2023.
  • Solomon MD, McNulty EJ, Rana JS, et al. The Covid19 pandemic and the incidence of acute myocardial infarction. N Engl J Med. 2020;383:691-3.
  • Su Y-H, Wu K-H, Su C-M, et al. Influence of the coronavirus disease 2019 pandemic on patients with ST-segment elevation myocardial infarction in Taiwan. Emerg Med Int. 2021;2021:5576220.
  • Velilla-Alonso G, García-Pastor A, Rodríguez-López Á, et al. Acute stroke care during the COVID-19 pandemic: reduction in the number of admissions of elderly patients and increase in prehospital delays. Cerebrovasc Dis. 2021;50:310-6.
  • Grave C, Gabet A, Puymirat E, et al. Myocardial infarction throughout 1 year of the COVID-19 pandemic: French nationwide study of hospitalization rates, prognosis and 90-day mortality rates. Arch Cardiovasc Dis. 2021;114:768-80.
  • Erol MK, Kayıkçıoğlu M, Kılıçkap M, et al. Treatment delays and in-hospital outcomes in acute myocardial infarction during the COVID-19 pandemic: a nationwide study. Anatol J Cardiol. 2020;24:334-42.
  • Cenko E, Badimon L, Bugiardini R, et al. Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on thrombosis and the association for acute CardioVascular care (ACVC), in collaboration with the European heart rhythm association (EHRA). Cardiovasc Res. 2021;117:2705-29.
  • Havenon A, Yaghi S, Mistry EA, et al. Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. J Neurointerv Surg. 2020;12:1045-8. Erratum in: J Neurointerv Surg. 2021;13:e26.
  • Mariet A-S, Duloquin G, Benzenine E, et al. Impact of the first COVID-19 wave on french hospitalizations for myocardial infarction and stroke: a retrospective cohort study. Biomedicines. 2022;10:2501.
  • De Luca L, Rosato S, D'Errigo P, et al. Covid19 diagnosis and mortality in patients with non-ST-elevation myocardial infarction admitted in Italy during the national outbreak. Int J Cardiol. 2023;370:447-53.
  • Görgülü Ü, Şahin MH, Bektaş H. Acute stroke in Covid-19 infection: neurology intensive care experience. Suleyman Demirel University Journal of Health Sciences. 2022;13:111-8.
  • Rinkel L, Prick J, Slot R, et al. Impact of the COVID-19 outbreak on acute stroke care. J Neurol. 2021;268:403-8.
  • Van Belle E, Manigold T, Pierache A, et al. Myocardial Infarction incidence during national lockdown in two French provinces unevenly affected by COVID-19 outbreak: An observational study. Lancet Reg Health Eur. 2021;2:100030.
  • Schwarz V, Mahfoud F, Lauder L, et al. Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19. Clin Res Cardiol. 2020;109:1500-6.
  • Lee K, Lee S, Lim J, et al. Providing essential clinical care for non-COVID-19 patients in a Seoul metropolitan acute care hospital amidst ongoing treatment of COVID-19 patients. J Hosp Infect. 2020;106:673-7.
  • Olié V, Carcaillon-Bentata L, Thiam M-M, et al. Emergency department admissions for myocardial infarction and stroke in France during the first wave of the COVID-19 pandemic: National temporal trends and regional disparities. Arch Cardiovasc Dis. 2021;114:371-80.
  • Gabet A, Grave C, Tuppin P, et al. Impact of the COVID‐19 pandemic and a national lockdown on hospitalizations for stroke and related 30‐day mortality in France: A nationwide observational study. Eur J Neurol. 2021;28:3279-88.
  • Quiles LEP, Diamante PAB, Pascual JLV. Impact of the COVID-19 pandemic in the acute stroke admissions and outcomes in a Philippine tertiary hospital. Cerebrovasc Dis Extra. 2022;12:76-84.
  • Saban M, Reznik A, Shachar T, et al. The effect of the COVID-19 pandemic on ED referrals and care for stroke patients: a four-year comparative study. J Crit Care. 2021;62:230-4.
  • Mesnier J, Cottin Y, Coste P, et al. Hospital admissions for acute myocardial infarction before and after lockdown according to regional prevalence of COVID-19 and patient profile in France: a registry study. The Lancet Public Health. 2020;5:e536-42.
  • Mafham MM, Spata E, Goldacre R, et al. COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England. Lancet. 2020;396:381-9.
  • Martí-Fàbregas J, Guisado-Alonso D, Delgado-Mederos R, et al. Impact of COVID-19 infection on the outcome of patients with ischemic stroke. Stroke. 2021;52:3908-17.
  • Dhamoon MS, Thaler A, Gururangan K, et al. Acute cerebrovascular events with COVID-19 infection. Stroke. 2021;52:48-56.
  • Benussi A, Pilotto A, Premi E, et al. Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy. Neurology. 2020;95:e910-20.

Investigation of the Increase in Cerebrovascular Disease and ST Elevation Myocardial Infarction Cases Before and During the Pandemic

Year 2025, Volume: 7 Issue: 2, 469 - 475, 09.05.2025
https://doi.org/10.37990/medr.1659469

Abstract

Aim: In this study, we aimed to investigate the effects of Coronavirus Disease 2019 (COVID-19) on the incidences of acute ischemic stroke (AIS) and ST elevation myocardial infarction (STEMI).
Material and Method: Patients admitted to the emergency department during the pandemic and pre-pandemic periods and diagnosed with AIS and/or STEMI. Demographic variables, comorbidities, diagnoses and mortality rates were compared between the two periods.
Results: The mean age of the patients was 71.8±13 years and 48.3% were male. The number of 255 ischemic patients (STEMI and/or AIS) admitted in the pre-pandemic period decreased to 165 during the pandemic period (p<0.05). During the pandemic period, there was a 38.2% decrease in the AIS group and a 29.1% decrease in the STEMI group. While the frequency of chronic renal failure and hyperlipidemia was found to be high in patients with AIS admitted during the pandemic period (p<0.05), there was no difference in terms of comorbidities in patients with STEMI (p>0.05). When the pre-pandemic and post-pandemic periods were compared, mortality was higher in the group with STEMI (p<0.05). In the STEMI group, the frequency of HL was higher in COVID-19 positive patients compared to COVID-19 negative patients (p<0.05).
Conclusion: Compared to the pre-pandemic period, the number of patients admitted due to AIS and STEMI decreased and mortality rates increased during the pandemic period.

Ethical Statement

It was performed retrospectively with the approval of the local ethics committee dated 20/06/2023 and numbered 2023-12/84 obtained from Kırşehir Ahi Evran University Faculty of Medicine Training and Research Hospital.

References

  • Lai C-C, Wang C-Y, Wang Y-H, et al. Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status. Int J Antimicrob Agents. 2020;55:105946.
  • WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/ access date: 01.11.2023.
  • Levi M, van der Poll T. Coagulation and sepsis. Thrombosis research. 2017;149:38-44.
  • Schmitt FCF, Manolov V, Morgenstern J, et al. Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study. Ann Intensive Care. 2019;9:19.
  • Gupta N, Zhao Y-Y, Evans CE. The stimulation of thrombosis by hypoxia. Thromb Res. 2019;181:77-83.
  • Terzioğlu K. Use of monocyte/HIGH-density lipoprotein-cholesterol ratio in determining the prognosis of patients presenting to the emergency department with ischemic cerebrovascular disease. Dissertation. Erzurum Atatürk University, 2021.
  • Fırat O, Karakuş M, Arsava E, et al. Comparison of guidelines in risk factor management of ischemic stroke. STED. 2021;30:211-7.
  • Li Y, Li M, Wang M, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. 2020;5:279-84.
  • Geleris J, Sun Y, Platt J, et al. Observational study of hydroxychloroquine in hospitalized patients with Covid-19. N Engl J Med. 2020;382:2411-8.
  • Nascimento BR, Brant LCC, Marino BC, et al. Implementing myocardial infarction systems of care in low/middle-income countries. Heart. 2019;105:20-6.
  • Karabacak M. Cardiovascular effects of COVID-19 pandemia. SDÜ Tıp Fakültesi Dergisi. 2021;28:229-33.
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62. Erratum in: Lancet. 2020;395:1038. Erratum in: Lancet. 2020;395:1038.
  • Small C, Mehkri Y, Panther E, et al. Coronavirus disease-2019 and stroke: pathophysiology and management. Can J Neurol Sci. 2023;50:495-502.
  • Mitra B, Mitchell RD, Cloud GC, et al. Presentations of stroke and acute myocardial infarction in the first 28 days following the introduction of State of Emergency restrictions for COVID‐19. Emerg Med Australas. 2020;32:1040-5.
  • Uslusoy DK. Retrospective analysis of the effects of the COVID-19 pandemic process on patients admitted to the emergency department with a diagnosis of cerebrovascular disease. Dissertation. Bursa Uludağ University, 2023.
  • Solomon MD, McNulty EJ, Rana JS, et al. The Covid19 pandemic and the incidence of acute myocardial infarction. N Engl J Med. 2020;383:691-3.
  • Su Y-H, Wu K-H, Su C-M, et al. Influence of the coronavirus disease 2019 pandemic on patients with ST-segment elevation myocardial infarction in Taiwan. Emerg Med Int. 2021;2021:5576220.
  • Velilla-Alonso G, García-Pastor A, Rodríguez-López Á, et al. Acute stroke care during the COVID-19 pandemic: reduction in the number of admissions of elderly patients and increase in prehospital delays. Cerebrovasc Dis. 2021;50:310-6.
  • Grave C, Gabet A, Puymirat E, et al. Myocardial infarction throughout 1 year of the COVID-19 pandemic: French nationwide study of hospitalization rates, prognosis and 90-day mortality rates. Arch Cardiovasc Dis. 2021;114:768-80.
  • Erol MK, Kayıkçıoğlu M, Kılıçkap M, et al. Treatment delays and in-hospital outcomes in acute myocardial infarction during the COVID-19 pandemic: a nationwide study. Anatol J Cardiol. 2020;24:334-42.
  • Cenko E, Badimon L, Bugiardini R, et al. Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on thrombosis and the association for acute CardioVascular care (ACVC), in collaboration with the European heart rhythm association (EHRA). Cardiovasc Res. 2021;117:2705-29.
  • Havenon A, Yaghi S, Mistry EA, et al. Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. J Neurointerv Surg. 2020;12:1045-8. Erratum in: J Neurointerv Surg. 2021;13:e26.
  • Mariet A-S, Duloquin G, Benzenine E, et al. Impact of the first COVID-19 wave on french hospitalizations for myocardial infarction and stroke: a retrospective cohort study. Biomedicines. 2022;10:2501.
  • De Luca L, Rosato S, D'Errigo P, et al. Covid19 diagnosis and mortality in patients with non-ST-elevation myocardial infarction admitted in Italy during the national outbreak. Int J Cardiol. 2023;370:447-53.
  • Görgülü Ü, Şahin MH, Bektaş H. Acute stroke in Covid-19 infection: neurology intensive care experience. Suleyman Demirel University Journal of Health Sciences. 2022;13:111-8.
  • Rinkel L, Prick J, Slot R, et al. Impact of the COVID-19 outbreak on acute stroke care. J Neurol. 2021;268:403-8.
  • Van Belle E, Manigold T, Pierache A, et al. Myocardial Infarction incidence during national lockdown in two French provinces unevenly affected by COVID-19 outbreak: An observational study. Lancet Reg Health Eur. 2021;2:100030.
  • Schwarz V, Mahfoud F, Lauder L, et al. Decline of emergency admissions for cardiovascular and cerebrovascular events after the outbreak of COVID-19. Clin Res Cardiol. 2020;109:1500-6.
  • Lee K, Lee S, Lim J, et al. Providing essential clinical care for non-COVID-19 patients in a Seoul metropolitan acute care hospital amidst ongoing treatment of COVID-19 patients. J Hosp Infect. 2020;106:673-7.
  • Olié V, Carcaillon-Bentata L, Thiam M-M, et al. Emergency department admissions for myocardial infarction and stroke in France during the first wave of the COVID-19 pandemic: National temporal trends and regional disparities. Arch Cardiovasc Dis. 2021;114:371-80.
  • Gabet A, Grave C, Tuppin P, et al. Impact of the COVID‐19 pandemic and a national lockdown on hospitalizations for stroke and related 30‐day mortality in France: A nationwide observational study. Eur J Neurol. 2021;28:3279-88.
  • Quiles LEP, Diamante PAB, Pascual JLV. Impact of the COVID-19 pandemic in the acute stroke admissions and outcomes in a Philippine tertiary hospital. Cerebrovasc Dis Extra. 2022;12:76-84.
  • Saban M, Reznik A, Shachar T, et al. The effect of the COVID-19 pandemic on ED referrals and care for stroke patients: a four-year comparative study. J Crit Care. 2021;62:230-4.
  • Mesnier J, Cottin Y, Coste P, et al. Hospital admissions for acute myocardial infarction before and after lockdown according to regional prevalence of COVID-19 and patient profile in France: a registry study. The Lancet Public Health. 2020;5:e536-42.
  • Mafham MM, Spata E, Goldacre R, et al. COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England. Lancet. 2020;396:381-9.
  • Martí-Fàbregas J, Guisado-Alonso D, Delgado-Mederos R, et al. Impact of COVID-19 infection on the outcome of patients with ischemic stroke. Stroke. 2021;52:3908-17.
  • Dhamoon MS, Thaler A, Gururangan K, et al. Acute cerebrovascular events with COVID-19 infection. Stroke. 2021;52:48-56.
  • Benussi A, Pilotto A, Premi E, et al. Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy. Neurology. 2020;95:e910-20.
There are 38 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Original Articles
Authors

Aysun Türker 0009-0001-5045-0582

Canan Şahin 0000-0002-8802-9558

Publication Date May 9, 2025
Submission Date March 17, 2025
Acceptance Date April 8, 2025
Published in Issue Year 2025 Volume: 7 Issue: 2

Cite

AMA Türker A, Şahin C. Investigation of the Increase in Cerebrovascular Disease and ST Elevation Myocardial Infarction Cases Before and During the Pandemic. Med Records. May 2025;7(2):469-475. doi:10.37990/medr.1659469

17741

Chief Editors

MD, Professor. Zülal Öner
İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Düzce University, Department of Anatomy, Düzce, Türkiye

Editors
Assoc. Prof. Serkan Öner
İzmir Bakırçay University, Department of Radiology, İzmir, Türkiye
 
E-mail: medrecsjournal@gmail.com

Publisher:
Medical Records Association (Tıbbi Kayıtlar Derneği)
Address: Orhangazi Neighborhood, 440th Street,
Green Life Complex, Block B, Floor 3, No. 69
Düzce, Türkiye
Web: www.tibbikayitlar.org.tr