Glargin U300'ün etkinliğinin geriye yönelik olarak değerlendirilmesi: Tek merkez deneyimi

Abstract

Amaç: Glargin U300'ün açlık kan şekeri (AKŞ) ve HbA1c üzerindeki uzun vadeli (12 ve 24 ay) etkilerini ve tedavi sırasında hipoglisemi gelişme sıklığını araştırmayı amaçladık. Yöntem: Ocak 2017-Ocak 2021 tarihleri arasında Dahiliye polikliniğine Tip 2 DM tanısı ile başvuran ve glargin U300 tedavisi başlanan 96 hasta retrospektif olarak incelendi. Bulgular: Tedavi başlangıcında ortalama kan glukoz düzeyi 252.19±92.55 mg/dl iken 12. ayda 203.08±82.09 mg/dl, 24. ayda 200.27±73.78 mg/dl ye kadar düşme saptandı. Benzer şekilde glargin U300 tedavisi ile HbA1c yüzdesinin hem 12 hem de 24. ayda anlamlı derecede düştüğü bulundu. Ortalama başlangıç HbA1c %9.9±1.925 iken 12. ayda 8.66±1.969 ve 24. ayda 8.51±1.430 idi. Glargin U- 300 tedavisi alan 96 hastanın altısında (%6.3) acil serviste hipoglisemi atağı geliştiği saptandı. Sonuç: Glargin U300, çalışma bulgularımızla da desteklendiği üzere hem hipoglisemi riskini azaltmada hem de hedefe yönelik glisemik kontrolü sağlamada etkin bir bazal insülindir.

Keywords

• Glargine U300
• hipoglisemi
• glisemik kontrol
• uzun etkili bazal insülin

Retrospective evaluation of the effectiveness of the glargine U300: A single center experience

Abstract

Objective: We investigated the long-term (12 and 24 months) effects of glargine U300 on fasting plasma glucose (FPG), HbA1c and the incidence of hypoglycemia in patients. Method: Patients who applied to the Internal Medicine outpatient clinic with the diagnosis of Type 2 DM between January 2017 and January 2021 and were started on glargine U300 were retrospectively analyzed. Results: Gla-300 treatment significantly improved mean blood glucose levels at both 12 and 24 months (tabtotcomp.). At the beginning of the treatment, the mean blood glucose level was 252.19±92.55 mg/dl. However, it was 203.08±82.09 mg/dl at the 12th month and 200.27±73.78 on the 24th month. Similarly, with Gla-300 treatment, the percentage of HbA1c was found to be significantly lower at both 12 and 24 months. The mean initial HbA1c was 9.9±1.925%, this value was found to be 8.66±1.969 at the 12th month and 8.51±1.43 at the 24th month. Conclusion: Glargine U300 is a long-acting basal insulin that both reduces the risk of hypoglycemia and provides targeted glycemic control, as supported by our study findings.

Keywords

• Glargine U300
• Hypoglycemia
• Glycemic control
• Long-acting basal insulin

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