Follow-up results of dolutegravir/lamiıvudine switch therapy

Year 2025, Volume: 18 Issue: 2, 233 - 243, 15.08.2025

Dilek Yağcı Çağlayık , Fatma Burcu Doğanç

https://doi.org/10.26559/mersinsbd.1643403

https://izlik.org/JA68ZB44GE

Abstract

Aim: Observing and revealing the switch reasons to dolutegravir/lamivudine (DTG/3TC) dual therapy, virological supression ratio, side effects, and monitoring of renal function during follow-up after switch in people living with HIV (PLWH) were aimed.
Method: Thirty-eight adult PLWH who were followed by a single physician and switched to dual therapy between 2015-2021 were retrospectively analyzed.
Results: The most common reason for switching to dual therapy was the prevention of potential renal toxicities, recorded as 44.7% (17/38), the median age was 51.5 years, and the median follow-up period was 54 months. Virological failure was not observed in any PLWH, including three PLWH that had Nucleoside Reverse Transcriptase Inhibitor (NRTI) mutation (K65R, M41L, K70T/S). There was a significant increase in CD4+ T lymphocyte number. Glomerular filtration rate (GFR) improvement and regression of proteinuria were recorded especially in the early period. The discontinuation rate due to side effects was 5.3% (2/38). The death rate was observed to be 18.4% (7/38), and the most common cause was myocardial infarction (4/7).
Conclusion: DTG/3TC, which is observed to be a regimen with high virological suppression success and low side effect rate, can be considered as an ideal treatment alternative in PLWH.

Keywords

HIV , Dolutegravir , Lamivudine

Dolutegravir/lamivudin geçiş tedavisi izlem sonuçları

https://izlik.org/JA68ZB44GE

Abstract

Amaç: Dolutegravir/lamivudin (DTG/3TC) ikili tedavisine geçiş yapılan HIV ile yaşayan bireylerdeki (HYB) ikili tedaviye geçiş sebepleri, ikili tedaviye geçişten sonra elde edilen virolojik baskılama başarısı, yan etkiler, takip sırasında böbrek fonksiyon seyrinin ortaya konulması amaçlanmıştır. Yöntem: Tek hekimden takipli olup 2015-2021 yılları arasında ikili tedaviye geçiş yapılan 38 erişkin HYB retrospektif olarak incelenmiştir. Bulgular: İkili tedaviye geçişte en sık sebep, potansiyel renal toksisistelerin önlenmesi %44,7(17/38) olarak kaydedildi, median yaş 51.5, median takip süresi 54 ay olarak saptandı. Nukleozid Reverse Transkriptaz İnhibitörü (NRTI) mutasyonu (K65R, M41L, K70T/S) izlenen üç HYB de dahil olmak üzere virolojik başarısızlık hiçbir HYB’de izlenmedi. CD4+ T lenfosit sayısında anlamlı artış izlendi. Glomerüler filtrasyon hızında (GFR) erken dönemde düzelme ve proteinüride gerileme kaydedildi. Yan etki nedeniyle kesilme oranı %5,3 (2/38) olarak izlendi. Ölüm oranı %18.4 (7/38) oranında izlendi, en sık sebebin myokard enfarktüsü (4/7) olduğu görüldü. Sonuç: Virolojik baskılama başarısı yüksek, yanetki oranı düşük bir rejim olduğu izlenen DTG/3TC , tedavi uyumu iyi olan HYB’ lerde ideal bir tedavi alternatifi olarak kabul edilebilir.

Keywords

HIV , Dolutegravir , Lamivudin

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