İmmünsüpresif olmayan hastada adenovirüs pnömonisi: olgu sunumu

Abstract

Adenovirüsler genellikle hafif üst solunum yolu enfeksiyonlarına neden olurken, immün sistemi sağlam bireylerde nadiren ciddi alt solunum yolu enfeksiyonlarına yol açabilir. Bu olgu sunumunda; daha önce sağlıklı ve immün yetmezliği olmayan genç bir kadında adenovirüs enfeksiyonuna bağlı gelişen pnömoni vakası sunulmuştur.

Keywords

• Adenovirüs
• pnömoni
• immünsüpresif olmayan hasta
• solunum yolu enfeksiyonu

Adenovirus pneumonia in an immunocompetent patient: a case report

Abstract

Adenoviruses typically lead to mild infections of the upper respiratory tract; however, they can, in rare cases, cause severe lower respiratory tract infections even in individuals with a healthy immune system. This case report discusses a pneumonia episode caused by adenovirus infection in a young woman who was previously healthy and immunocompetent.

Keywords

• Adenovirus
• pneumonia
• immunocompetent patient
• respiratory tract infection

References

1. Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev. 2014;27(3):441-462. doi:10.1128/CMR.00116-13
2. Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol. 2003;13(3):155-171. doi:10.1002/rmv.386
3. Lynch JP 3rd, Fishbein M, Echavarria M. Adenovirus. Semin Respir Crit Care Med. 2011;32(4):494-511. doi:10.1055/s-0031-1283287
4. Hakim FA, Tleyjeh IM. Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature. Eur J Clin Microbiol Infect Dis. 2008;27(2):153-158. doi:10.1007/s10096-007-0416-z
5. Matthes-Martin S, Feuchtinger T, Shaw PJ, et al. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: Summary of ECIL-4. Transpl Infect Dis. 2012;14(6):555-563. doi:10.1111/tid.12022
6. Kolavic-Gray SA, Binn LN, Sanchez JL, et al. Large epidemic of adenovirus type 4 infection among military trainees: epidemiological, clinical, and laboratory studies. Clin Infect Dis. 2002;35(7):808-818. doi:10.1086/342573
7. Kim D, Lee E, Eom J, et al. Prevalence and Burden of Human Adenovirus-Associated Acute Respiratory Illness in the Republic of Korea Military, 2013 to 2022. J Korean Med Sci. 2024;39(4):e38. doi:10.3346/jkms.2024.39.e38
8. Sanchez MP, Erdman DD, Torok TJ, Freeman CJ, Matyas BT. Outbreak of adenovirus 35 pneumonia among adult residens and staff of a chronic care psychiatric facility. J Infect Dis. 1997;176(3):760-763. doi:10.1086/517295

9. Zhang SY, Luo YP, Huang DD, et al. Fatal pneumonia cases caused by human adenovirus 55 in immunocompetent adults. Infect Dis (Lond). 2016;48(1):40-47. doi:10.3109/23744235.2015.1055585
10. Lin F, Zhou Q, Li W, et al. A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis. BMC Pulm Med. 2023;23(1):431. doi:10.1186/s12890-023-02742-8
11. Dandachi D, Rodriguez-Barradas MC. Viral pneumonia: etiologies and treatment. J Investig Med. 2018;66(6):957-965. doi:10.1136/jim-2018-000712
12. Alzafer, S., & Üstün, C. Askeri Kışlada Gelişen Adenovirus Pnömonisi: Bir Olgu Sunumu. Klimik Dergisi. 2020;33(2),173-5. doi: 10.5152/kd.2020.36
13. Isbilen, G. S., Guner, T., Karadag, F. Y., & Engin, D. O. Immunokompetan Bir Bireyde Siddetli Seyreden Adenovirus Pnomonisi. Mediterranean Journal of Infection, Microbes and Antimicrobials. 2025;14(S1), 302.
14. Clark TW, Fleet DH, Wiselka MJ. Severe community-acquired adenovirus pneumonia in an immunocompetent 44-year-old woman: a case report and review of the literature. J Med Case Rep. 2011;5:259. doi:10.1186/1752-1947-5-259
15. Zhang L, Guo Y, Wang X, Gai W, Liu L. Severe adenovirus pneumonia complicated by acute respiratory distress syndrome in immunocompetent patients: a case report and literature review. Front Med (Lausanne). 2025;12:1524783. doi:10.3389/fmed.2025.1524783
16. Darılmaz Yüce G, Akçay Ş. İmmünsüpresif Hastalarda Viral Pnömoniler: Ne Zaman ve Nasıl?. İçinde: Bülbül Y, Buruk CK, Erçen Diken Ö. Güncel Göğüs Hastalıkları Serisi Kitapları. 1. Baskı. Ankara, Çankaya: Dünya Tıp Kitapevi; 2021: 44-69
17. Bozok T, Şimşek T. Üçüncü basamak bir hastanede rotavirüs, enterik adenovirüs ve enterik parazit enfeksiyonlarının prevalansı ve demografik özellikleri: Altı yıllık retrospektif kesitsel çalışma. Mersin Univ Saglık Bilim Derg. 2021;14(2):199-207. doi:10.26559/mersinsbd.862795