Synthesis of bis-1,2,3-triazole derivatives and potentiometric determination of their acid dissociation constants

Abstract

Aim: This study aimed to synthesize bis-1,2,3-triazole derivatives exhibiting anti-inflammatory activity, and to potentiometrically determine their acid dissociation constants, which represent a critical role in drug R&D studies. Method: The bis-1,2,3-triazole derivatives were synthesized by click chemistry. The acid dissociation constants of the compounds were determined using the HYPERQUAD computer program based on data obtained from potentiometric titrations, a technique widely considered as one of the reference methods in this field. Results: Three pKa values (pKa1= 2.84±0.02 - 3.24±0.06; pKa2= 6.39±0.01 - 6.62±0.03; pKa3= 10.25±0.01 - 10.64±0.03) were calculated for each of the bis-1,2,3-triazole derivatives. Conclusion: Eight bis-1,2,3-triazole derivatives were synthesized with high yields, and their structures were characterized by various analytical methods. Potentiometrically determined acid dissociation constants for these anti-inflammatory bis-1,2,3-triazole derivatives will provide crucial data for future studies on these compounds.

Keywords

• Anti-inflammatory
• acid dissociation constant
• HYPERQUAD
• potentiometric titration
• triazole

Supporting Institution

An “Ethics Committee” is not required for the presented study.

Project Number

Sunulan çalışma için “Etik Kurul” gerekli değildir.

Ethical Statement

An “Ethics Committee” is not required for the presented study.

Thanks

An “Ethics Committee” is not required for the presented study.

Bis-1,2,3-triazol türevlerinin sentezi ve asit dissosiyasyon sabitlerinin potansiyometrik tayini

Abstract

Amaç: Antienflamatuvar etki gösteren bis-1,2,3-triazol türevi bileşiklerin sentezi ve ilaç Ar-Ge çalışmalarında kritik rol oynayan parametrelerden biri olan asit dissosiyasyon sabitlerinin potansiyometrik olarak belirlenmesi amaçlandı. Yöntem: Bis-1,2,3-triazol türevi bileşikler klik kimyası ile sentezlendi. Bileşiklerin asit dissosiyasyon sabitleri bu alanda referans metotlardan biri olarak kabul edilen potansiyometrik titrasyon yöntemi ile gerçekleştirilen titrasyonlardan HYPERQUAD bilgisayar programıyla belirlendi. Bulgular: Bis-1,2,3-triazol türevi bileşiklerin her biri için üçer pKa değeri (pKa1= 2.84±0.02 - 3.24±0.06; pKa2= 6.39±0.01 - 6.62±0.03; pKa3= 10.25±0.01 - 10.64±0.03) hesaplandı. Sonuç: Bis-1,2,3-triazol türevi sekiz adet bileşik yüksek verimle sentezlenerek yapıları çeşitli analitik yöntemlerle karakterize edildi. Antienflamatuvar etki gösteren bis-1,2,3-triazol türevleri için potansiyometrik olarak belirlenen asit dissosiyasyon sabitleri bu bileşikler ile ilgili gerçekleştirilecek yeni çalışmalar için önemli bilgiler sağlayacaktır.

Keywords

• Antienflamatuvar
• asit dissosiyasyon sabiti
• HYPERQUAD
• potansiyometrik titrasyon
• triazol

Supporting Institution

Sunulan çalışma için “Etik Kurul” gerekli değildir.

Project Number

Sunulan çalışma için “Etik Kurul” gerekli değildir.

Ethical Statement

Sunulan çalışma için “Etik Kurul” gerekli değildir.

Thanks

Sunulan çalışma için “Etik Kurul” gerekli değildir.

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