Pentraksinler

Abstract

Pentraksinler evrimsel olarak korunmuş olan bir protein ailesidir. Pentraksinler alt biriminin birincil yapısına göre kısa ve uzun pentraksinler olarak iki gruba ayrılır. Gen organizasyonunu, kromozom lokalizasyonunu ve ligand-tanıma yeteneğine uzun ve kısa pentraksinler farklılık gösterebilirler. Kısa pentraksinlerden C-reaktif protein ve serum amiloid P bileşeni çoğunlukla interlökin-6’ nın uyarılması ile karaciğerden sentezlenir. Uzun pentraksinlerin ilk olarak keşfedilen en önemli üyesi olan Pentraksin-3, endotelyal hücreler ve fibroblastlarda bir sitokin ile uyarılabilir bir gen olarak sentezlenir. Bu derlemede, özellikle pentraksin-3 olmak üzere pentraksin ailesi üyelerinin özellikleri ve yapısı ile ilgili bilgilerin aktarılması amaçlanmaktadır.

Anahtar Sözcükler: pentraksin-3, kısa pentraksinler, uzun pentraksinler

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