Yoğunluk ayarlı radyoterapi yapılan meme kanseri hastalarında, tiroid bezinde ikincil malignite gelişme riski tahmini

Year 2018, , 295 - 302, 25.12.2018

Songül Barlaz Us Aytül Kanat Yusuf Tolga Şanlı

https://doi.org/10.26559/mersinsbd.414986

Abstract

Amaç: Meme radyoterapisinden (RT) sonra tiroid bezinde
radyasyona bağlı ikincil malignite gelişme riski artmaktadır. Bu çalışmada yoğunluk
ayarlı radyoterapi (Intensity modulated radiotherapy-IMRT) yapılan meme kanseri
hastalarında tiroid bezi malignitesi gelişme riskinin değerlendirilmesi
amaçlanmıştır. Yöntem: Çalışmada
total mastektomi ve meme koruyucu cerrahi sonrası IMRT uygulanan 70 meme
hastası değerlendirilmiştir. Hastalarda tiroid bezinde ikincil malignite
gelişme riski, ERR (Estimating relative risk-tahmini rölatif risk) modeli
kullanılarak hesaplanmıştır. Bulgular:
Supra klaviküler bölgenin, RT alanına dahil edildiği hastalarda (Grup-1), ERR
değeri supraklaviküler bölgenin RT alanına dahil edilmediği hastalardan
(Grup-2) daha yüksek olduğu görülmüştür. ERR değerleri, yaş arttıkça
eksponansiyel olarak azalmıştır. Gruplar arasındaki tiroid bezi dozları farklı
olmasına rağmen, yaş arttıkça iki gruptaki ERR değerleri birbirine yaklaşmıştır.
Sonuç: Meme IMRT’si sonrası, tiroid
bezinde ikincil malignite gelişme riski, genç hastalarda daha yüksektir. Bu
nedenle genç hastalardaki RT uygulamalarında sağlam ve geçerli risk
değerlendirmesi tavsiye edilmektedir. 

Keywords

Meme IMRT, tiroid bezi, ikincil malignite riski

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