Clinical and pathological characteristics of triple-negative breast cancer patients: A single-center experience

Abstract

Aim: Triple negative breast cancer in which estrogen, progesterone receptors and c-erbB2 overexpression are negative, seems to have different clinical course and recurrence pattern. We retrospectively evaluated clinical demographic and pathological characteristics of triple negative breast cancers and investigated the association of these characteristics with OS and PFS, and also we aimed to identify prognostic factors, chemotherapy effects, survival rates, and the factors that effect survival rates. 

Method: 59 patients with triple negative breast cancer patients followed in Başkent University Hospital between 1997-2009 were evoluated retrospectively. Results: The median age of patients was 49. Median follow-up duration was 27 months (0.27-132 months). Two patients died during the follow-up. Invasive ductal carcinoma pathology was reported in 38 patients, invasive lobular in 3 patients, medullary in 5 patients. Almost half of the patients had LVI. 79% of patients had a T2 disease. 30% of patients’ tumor histological grade was III. Cancer history in the family was present in 95% of patients. Almost half of the patients had stage II disease. Adjuvant chemotherapy was given to 43 patients. Relapses were observed in 15 patients.The most common metastatic site was lung. Patients having high grade tumor, >3 (+) lymph nodes, younger age have higher chance of relapse during follow-up. Conclusions: In accordance with the literature, our triple negative breast cancer patients showed more aggressive characteristics. Although median follow-up is short, one-fourth of the patients having recurrence support natue of the triple negative breast cancer patients. In our study, triple negative patients had younger age at diagnosis, high grade tumors and more tendency to metastasize to visceral organs.

Keywords

• Estrogen receptors,progesteron receptors,cerbB2 receptor

Üçlü negatif meme kanserlerinin klinik ve demografik verileri-tek merkez deneyimi

Abstract

Giriş: Östrojen progesteron ve c-erbB2 ekspresyonu negatif olan üçlü negatif meme kanserleri, diğer meme kanser türlerine göre daha kötü prognoza sahiptir. Bu çalışmada üçlü negatif meme kanserlerinin klinik demografik ve patolojik karakteristikleri ve bu karakteristiklerin genel sağkalım ve progresyonsuz sağkalımla olan ilişkisi retrospektif olarak incelenerek prognostik faktörler, kemoterapi etkinlikleri ve sağkalım oranları ile sağkalıma etki eden faktörlerin belirlenmesi amaçlanmıştır. Yöntem: Başkent Üniversitesi Hastanesinde 1997-2009 arasında takipli üçlü negatif meme kanserli hasta retrospektif olarak incelendi. Bulgular: Hastaların median yaşları 49 idi. Median takip süresi 27 ay idi (0.27-132 ay). İki hasta takip sırasında ex oldu. 38 hastada invaziv duktal karsinom, üç hastada invaziv lobuler karsinom, beş hastada meduller karsinom saptandı. Hastaların neredeyse yarısında lenf nodu invazyonu vardı. %79 hastanın T2 hastalığı vardı. Hastaların %30 unun tümör histolojik derece III, ve neredeyse yarısında evre II hastalık vardı. %95 inde ailede kanser öyküsü mevcuttu. Adjuvan kemoterapi 43 hastaya verildi. 15 hastada relaps gözlendi. En sık metastaz akciğere idi. Yüksek dereceli tümörü olan, üçden fazla lenf nodu tutulan, ve genç yaşta olanların takiplerde daha fazla relaps olduğu görüldü. Tartışma: Literatürle uyumlu bir şekilde, bizim üçlü negatif meme kanserli hastalarımız da agresif karakteristikliydi. Median takip süresi kısa olmasına rağmen üçlü negatif meme kanserli hastaların doğasını destekleyecek şekilde ¼ hastada rekürrens izlendi. Çalışmamızda hastalarımız daha genç yaşta tanı almış, yüksek dereceli tümörlü ve visseral organlara metastaz yapma eğilimleri daha fazla idi. 

Keywords

• östrojen reseptöü,progesteron reseptörü,cerbB2 reseptörü

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