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Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi

Year 2020, Volume: 13 Issue: 2, 235 - 240, 26.08.2020
https://izlik.org/JA95LP97PN

Abstract

Amaç: Postmenopozal dönemde endometrial biyopsi yapılan hastalarda endometrial polip sıklığı ve obezite ile ilişkisi incelenmiştir. Yöntem: Ocak 2016- Haziran 2019 yılları arasında FSH değeri >30 olan ve en az bir yıldır adet görmeyen menopozdaki hastalarda farklı endikasyonlarla endometrial biyopsi yapılan toplam 310 hasta retrospektif olarak incelenmiştir. Bulgular: En sık biyopsi endikasyonunun %53.8 ile postmenopozal kanama olduğu izlendi. Patoloji sonuçlarında endometrial polip oranının %25.80 olduğu saptandı. Vücut kitle indeksine göre hastalar gruplandırıldığında VKİ 25’in altında olan olgularda %19.65, VKİ 25 ve üzerinde olan hastalarda %26.89 oranında endometrial polip gözlendi. Sonuç: Vücut kitle indeksi 25’in üzerinde olan hastalarda endometrial polip oranı yaklaşık %7 daha fazla olmasına rağmen VKİ 25’in altında olan hastalarla aralarında istatistiksel olarak anlamlı bir fark saptanmamıştır.

References

  • 1. Reslova T, Tosner J, Resl M, et al. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999;262(3–4):133–139.
  • 2. Nijkang NP, Anderson L, Markham R, Manconi F. Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Med. 2019 doi: 10.1177/2050312119848247.
  • 3. Giordano G, Gnetti L, Merisio C, Melpignano M. Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. Maturitas. 2007;56(2):190-197.
  • 4. Indraccolo U, Di Iorio R, Matteo M, et all The pathogenesis of endometrial polyps: A systematic semi-quantitative review Eur J Gynaecol Oncol. 2013;34(1):5-22.
  • 5. Dreisler E, Stampe Sorensen S, Ibsen PH, Lose G Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet Gynecol. 2009;33(1):102-108.
  • 6. Onalan R, Onalan G, Tonguc E, et al. Body mass index is an independent risk factor for the development of endometrial polyps in patients undergoing in vitro fertilization Fertil Steril. 2009;91(4):1056-1060.
  • 7. Nappi L, Indraccolo U, Di Spiezio Sardo A, Gentile G, Palombino K, Castaldi MA, Spinelli M, Greco P. Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol. 2009;16(2):157-62.
  • 8. Gao J, Tian J, Lv Y, Shi F, Kong F, Shi H, et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci.2009. 100:389–395
  • 9. Erdemoglu E, Güney M, Karahan N and Mungan T. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. Maturitas. 2008.59:268–274.
  • 10. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: A review of the evidence. J Nutr. 2001;131(11Suppl):3109S-20S.
  • 11. Belisário MS, Vassallo J, Andrade LA, et all. The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index. Maturitas. 2006;53(1):114-118.
  • 12. Gul A, Ugur M, Iskender C, Zulfikaroglu E and Ozaksit G, Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and its relationship to clinical parameters. Arch Gynecol Obstet. 2010;281(3):479–483.
  • 13. Sant'Ana de Almeida EC, Nogueira AA, et al. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas. 2004;49(3):229-233.
  • 14. Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J. Diagnosis and management of endometrial polyps: A critical review of the literature. J Minim Invasive Gynecol. 2011;18(5):569-581

Evaluation of the relationship between endometrial polyps and obesity in postmenopausal period

Year 2020, Volume: 13 Issue: 2, 235 - 240, 26.08.2020
https://izlik.org/JA95LP97PN

Abstract

Aim: The aim of this study to investigate the relationship of obesity and postmenopausal endometrial polyps. Method: 310 patients with FSH> 30 between January 2016 and June 2019 who underwent endometrial biopsy with different indications were included in the study. Results: The most common indication for biopsy was postmenopausal bleeding with 53.8%. In pathology results, the rate of endometrial polyps was found 25.80%. When the patients were grouped according to body mass index (BMI), endometrial polyps were observed in 19.65% of patients with BMI below 25, and 26.89% in patients with BMI of 25 and above. Conclusion: Although the endometrial polyps rate is about 7% higher in patients with BMI above 25, there was no statistically significant difference between patients with BMI below 25.

References

  • 1. Reslova T, Tosner J, Resl M, et al. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999;262(3–4):133–139.
  • 2. Nijkang NP, Anderson L, Markham R, Manconi F. Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Med. 2019 doi: 10.1177/2050312119848247.
  • 3. Giordano G, Gnetti L, Merisio C, Melpignano M. Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. Maturitas. 2007;56(2):190-197.
  • 4. Indraccolo U, Di Iorio R, Matteo M, et all The pathogenesis of endometrial polyps: A systematic semi-quantitative review Eur J Gynaecol Oncol. 2013;34(1):5-22.
  • 5. Dreisler E, Stampe Sorensen S, Ibsen PH, Lose G Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet Gynecol. 2009;33(1):102-108.
  • 6. Onalan R, Onalan G, Tonguc E, et al. Body mass index is an independent risk factor for the development of endometrial polyps in patients undergoing in vitro fertilization Fertil Steril. 2009;91(4):1056-1060.
  • 7. Nappi L, Indraccolo U, Di Spiezio Sardo A, Gentile G, Palombino K, Castaldi MA, Spinelli M, Greco P. Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol. 2009;16(2):157-62.
  • 8. Gao J, Tian J, Lv Y, Shi F, Kong F, Shi H, et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci.2009. 100:389–395
  • 9. Erdemoglu E, Güney M, Karahan N and Mungan T. Expression of cyclooxygenase-2, matrix metalloproteinase-2 and matrix metalloproteinase-9 in premenopausal and postmenopausal endometrial polyps. Maturitas. 2008.59:268–274.
  • 10. Giovannucci E. Insulin, insulin-like growth factors and colon cancer: A review of the evidence. J Nutr. 2001;131(11Suppl):3109S-20S.
  • 11. Belisário MS, Vassallo J, Andrade LA, et all. The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index. Maturitas. 2006;53(1):114-118.
  • 12. Gul A, Ugur M, Iskender C, Zulfikaroglu E and Ozaksit G, Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and its relationship to clinical parameters. Arch Gynecol Obstet. 2010;281(3):479–483.
  • 13. Sant'Ana de Almeida EC, Nogueira AA, et al. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas. 2004;49(3):229-233.
  • 14. Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J. Diagnosis and management of endometrial polyps: A critical review of the literature. J Minim Invasive Gynecol. 2011;18(5):569-581
There are 14 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Susan Mammadova This is me 0000-0002-1919-0639

Hüseyin Durukan 0000-0001-5894-3421

Gürkan Yazıcı 0000-0003-1890-5863

Submission Date February 15, 2020
Acceptance Date June 2, 2020
Publication Date August 26, 2020
DOI https://doi.org/10.26559/mersinsbd.689505
IZ https://izlik.org/JA95LP97PN
Published in Issue Year 2020 Volume: 13 Issue: 2

Cite

APA Mammadova, S., Durukan, H., & Yazıcı, G. (2020). Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 13(2), 235-240. https://doi.org/10.26559/mersinsbd.689505
AMA 1.Mammadova S, Durukan H, Yazıcı G. Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi. Mersin Univ Saglık Bilim derg. 2020;13(2):235-240. doi:10.26559/mersinsbd.689505
Chicago Mammadova, Susan, Hüseyin Durukan, and Gürkan Yazıcı. 2020. “Postmenopozal Dönemde Endometrial Poliplerin Obezite Ile Ilişkisi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13 (2): 235-40. https://doi.org/10.26559/mersinsbd.689505.
EndNote Mammadova S, Durukan H, Yazıcı G (August 1, 2020) Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13 2 235–240.
IEEE [1]S. Mammadova, H. Durukan, and G. Yazıcı, “Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi”, Mersin Univ Saglık Bilim derg, vol. 13, no. 2, pp. 235–240, Aug. 2020, doi: 10.26559/mersinsbd.689505.
ISNAD Mammadova, Susan - Durukan, Hüseyin - Yazıcı, Gürkan. “Postmenopozal Dönemde Endometrial Poliplerin Obezite Ile Ilişkisi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 13/2 (August 1, 2020): 235-240. https://doi.org/10.26559/mersinsbd.689505.
JAMA 1.Mammadova S, Durukan H, Yazıcı G. Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi. Mersin Univ Saglık Bilim derg. 2020;13:235–240.
MLA Mammadova, Susan, et al. “Postmenopozal Dönemde Endometrial Poliplerin Obezite Ile Ilişkisi”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 13, no. 2, Aug. 2020, pp. 235-40, doi:10.26559/mersinsbd.689505.
Vancouver 1.Susan Mammadova, Hüseyin Durukan, Gürkan Yazıcı. Postmenopozal dönemde endometrial poliplerin obezite ile ilişkisi. Mersin Univ Saglık Bilim derg. 2020 Aug. 1;13(2):235-40. doi:10.26559/mersinsbd.689505

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