The frequency and importance of combined non-alcoholic fatty liver disease in patients with chronic viral hepatitis

Abstract

Aim: The aim of the study is to determine the hepatosteatosis diagnosed as chronic viral hepatitis in liver biopsies and to reveal the relationship with the parameters in scoring systems and thus to predict the course of the disease. Method: Preparations of 110 cases diagnosed with chronic viral hepatitis in two different university hospitals were re-evaluated and scored based on modified histologic activity index and nonalcoholic fatty liver disease activity score (NAS) scoring system. The relationship between the parameters of these two scoring systems was examined. Results: Hepatosteatosis accompanies our chronic hepatitis C cases with a rate of 34.8% and chronic hepatitis B cases with a rate of 44.8%. As the steatosis score increases, the fibrosis scores of the cases also increase. Conclusion: Chronic viral hepatitis and nonalcoholic fatty liver disease (NAFLD), which are common chronic liver diseases, should not always be considered as separate entities. It should also be kept in mind that those can be occurred together. It will be important in terms of the course of disease that steatohepatosis accompanying chronic viral hepatitis cases should be stated in pathology reports.

Keywords

• Chronic hepatitis
• nonalcoholic fatty liver disease
• fibrosis

Kronik viral hepatitli olgularda kombine non-alkolik yağlı karaciğer hastalığının sıklığı ve önemi

Abstract

eden hepatosteatozun belirlenerek bunların skorlama sistemlerindeki parametreler ile ilişkisinin ortaya konması ve böylelikle hastalığın seyri ile ilgili öngörüde bulunmaktır. Yöntem: İki farklı üniversite hastanesinde kronik viral hepatit tanısı almış 110 olguya ait preperatlar yeniden değerlendirilmiş ve modifiye histolojik aktivite indeksi ve nonalkolik yağlı karaciğer hastalığı aktivite skoru (NAS) skorlama sistemleri esas alınarak skorlanmıştır. Bu iki skorlama sistemine ait parametreler arasındaki ilişki incelenmiştir. Bulgular: Hepatosteatoz, kronik hepatit C’li olgularımıza %34.8 oranında, kronik hepatit B olgularımıza ise %44.8 oranında eşlik etmektedir. Steatoz skoru arttıkça olgulara ait fibrozis skorları da artmaktadır. Sonuç: Sık görülen kronik karaciğer hastalıkları olan kronik viral hepatit ve nonalkolik yağlı karaciğer hastalığı (NAFLD) her zaman ayrı antiteler olarak kabul edilmemeli, birlikte görülebileceği de akılda tutulmalıdır. Kronik viral hepatitli olgulara eşlik eden steatohepatozun da patoloji raporlarında belirtilmesi hastalığın seyri açısından önem arz edecektir.

Keywords

• kronik hepatit
• nonalkolik yağlı karaciğer hastalığı
• fibrozis

Thanks

Verilerin istatistiksel analizini yapan Arş. Gör. Dr. Damla Hazal SUCU’ ya teşekkür ederiz

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