Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm
Abstract
Abdominal aortic aneurysm (AAA) is a cardiovascular disease caused by the enlargement of the aorta in the abdomen over time. Unless treated, the growth of AAA continues, resulting in 80% death in the case of rupture. Today, the width of the aneurysm diameter is taken into account in clinical practice to examine the status of AAA. Although there are aneurysms that do not rupture despite reaching a diameter of 9 cm, it is reported that aneurysms with a diameter of 3 cm are ruptured in several cases. Therefore, analyzing only the AAA diameter is not a reliable method, and a deeper investigation is necessary for the rupture risk assessment. In this study, a patient's situation is analyzed using computational fluid dynamics (CFD) simulations, which allows to elucidate the flow dependent parameters such as velocity, vorticity, pressure, and wall shear stress (WSS). First, the patient-specific geometry was obtained and boundary conditions were defined at the inlet and the outlet of the flow domain. The effects of intraluminal thrombus (ILT) formation and patient’s effort conditions were also included in the analysis. According to the results, WSS and vorticity increase with the increasing blood flow velocity. In terms of the rupture risk, it has been found that the effect of patient’s effort level is more critical than the amount of ILT in the AAA.
Keywords
abdominal aortic aneurysm, cardiovascular biomechanics, computational fluid dynamics, hemodynamic analysis
Supporting Institution
TÜBİTAK - TÜRKİYE BİLİMSEL VE TEKNOLOJİK ARAŞTIRMA KURUMU
Project Number
221M001
Thanks
This study is funded by TÜBİTAK (The Scientific and Technological Research Council of Türkiye) 3501-Career Development Program (Project number: 221M001).
References
- [1]. Mutlu O, Salman H.E., Al-Thani H., El-Menyar A., Qidwai U.A., Yalcin H.C., “How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative residence time”, Computers in Biology and Medicine, 154, (2023), 106609.
- [2]. Bengtsson H., Bergqvist D., “Ruptured abdominal aortic aneurysm: a population-based study”, Journal of Vascular Surgery, 18, (1993), 74-80.
- [3]. Kontopodis N., Metaxa E., Papaharilaou Y., Tavlas E., Tsetis D., Ioannou C., “Advancements in identifying biomechanical determinants for abdominal aortic aneurysm rupture” Vascular, 23, (2014), 65-77.
- [4]. Salman H.E., Ramazanli B., Yavuz M.M., Yalcin H.C., “Biomechanical investigation of disturbed hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and experimental techniques”, Frontiers in bioengineering and biotechnology, 7, (2009), 111.
- [5]. Hafez H., Druce P.S., Ashton H.A., “Abdominal aortic aneurysm development in men following a “normal” aortic ultrasound scan”, European Journal of Vascular and Endovascular Surgery, 36, (2008), 553-558.
- [6]. Arslan A.C., Salman H.E., “Effect of intraluminal thrombus burden on the risk of abdominal aortic aneurysm rupture”, Journal of Cardiovascular Development and Disease, 10, (2023), 233.
- [7]. Salman H.E., “Pıhtı birikiminin abdominal aort anevrizması yırtılma riskine etkisinin mühendislik yöntemleriyle incelenmesi”, Fırat Üniversitesi Mühendislik Bilimleri Dergisi, 35, (2023), 597-614.
- [8]. Chaikof E.L., Brewster D.C., Dalman R.L., Makaroun M.S., Illig K.A., Sicard G.A., Timaran C.H., Upchurch Jr G.R., Veith F.J., “The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines” Journal of Vascular Surgery, 50, (2009), 2-49.
- [9]. Kalipcilar A., Salman H.E., “Hemodynamic effects of intraluminal thrombus burden in an idealized abdominal aortic aneurysm”, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 45, (2023), 508.
- [10]. Les A.S., Shadden S.C., Figueroa C.A., Park J.M., Tedesco M.M., Herfkens R.J., Dalman R.L., Taylor C.A., “Quantification of Hemodynamics in Abdominal Aortic Aneurysms During Rest and Exercise Using Magnetic Resonance Imaging and Computational Fluid Dynamics”, Annals of Biomedical Engineering, 38, (2010), 1288- 1313.