Abdominal aortic aneurysm (AAA) is a cardiovascular disease caused by the enlargement of the aorta in the abdomen over time. Unless treated, the growth of AAA continues, resulting in 80% death in the case of rupture. Today, the width of the aneurysm diameter is taken into account in clinical practice to examine the status of AAA. Although there are aneurysms that do not rupture despite reaching a diameter of 9 cm, it is reported that aneurysms with a diameter of 3 cm are ruptured in several cases. Therefore, analyzing only the AAA diameter is not a reliable method, and a deeper investigation is necessary for the rupture risk assessment. In this study, a patient's situation is analyzed using computational fluid dynamics (CFD) simulations, which allows to elucidate the flow dependent parameters such as velocity, vorticity, pressure, and wall shear stress (WSS). First, the patient-specific geometry was obtained and boundary conditions were defined at the inlet and the outlet of the flow domain. The effects of intraluminal thrombus (ILT) formation and patient’s effort conditions were also included in the analysis. According to the results, WSS and vorticity increase with the increasing blood flow velocity. In terms of the rupture risk, it has been found that the effect of patient’s effort level is more critical than the amount of ILT in the AAA.
TÜBİTAK - TÜRKİYE BİLİMSEL VE TEKNOLOJİK ARAŞTIRMA KURUMU
Project Number
221M001
Thanks
This study is funded by TÜBİTAK (The Scientific and Technological Research Council of Türkiye) 3501-Career Development Program (Project number: 221M001).
References
[1]. Mutlu O, Salman H.E., Al-Thani H., El-Menyar A., Qidwai U.A., Yalcin H.C., “How does hemodynamics affect
rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters,
time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative
residence time”, Computers in Biology and Medicine, 154, (2023), 106609.
[2]. Bengtsson H., Bergqvist D., “Ruptured abdominal aortic aneurysm: a population-based study”, Journal of
Vascular Surgery, 18, (1993), 74-80.
[3]. Kontopodis N., Metaxa E., Papaharilaou Y., Tavlas E., Tsetis D., Ioannou C., “Advancements in identifying
biomechanical determinants for abdominal aortic aneurysm rupture” Vascular, 23, (2014), 65-77.
[4]. Salman H.E., Ramazanli B., Yavuz M.M., Yalcin H.C., “Biomechanical investigation of disturbed
hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and
experimental techniques”, Frontiers in bioengineering and biotechnology, 7, (2009), 111.
[5]. Hafez H., Druce P.S., Ashton H.A., “Abdominal aortic aneurysm development in men following a “normal”
aortic ultrasound scan”, European Journal of Vascular and Endovascular Surgery, 36, (2008), 553-558.
[6]. Arslan A.C., Salman H.E., “Effect of intraluminal thrombus burden on the risk of abdominal aortic
aneurysm rupture”, Journal of Cardiovascular Development and Disease, 10, (2023), 233.
[8]. Chaikof E.L., Brewster D.C., Dalman R.L., Makaroun M.S., Illig K.A., Sicard G.A., Timaran C.H., Upchurch Jr G.R.,
Veith F.J., “The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice
guidelines” Journal of Vascular Surgery, 50, (2009), 2-49.
[9]. Kalipcilar A., Salman H.E., “Hemodynamic effects of intraluminal thrombus burden in an idealized
abdominal aortic aneurysm”, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 45,
(2023), 508.
[10]. Les A.S., Shadden S.C., Figueroa C.A., Park J.M., Tedesco M.M., Herfkens R.J., Dalman R.L., Taylor C.A.,
“Quantification of Hemodynamics in Abdominal Aortic Aneurysms During Rest and Exercise Using Magnetic
Resonance Imaging and Computational Fluid Dynamics”, Annals of Biomedical Engineering, 38, (2010), 1288-
1313.
[11]. Salman H.E., “Numerical modeling of the sound generated on an intracranial aneurysm using
computational fluid dynamics”, Düzce University Journal of Science & Technology, 11, (2023), 908-921.
[13]. Salman H.E., Yalcin H.C., “Computational investigation of the effect of wall thickness on rupture risk in
abdominal aortic aneurysms”, Journal of Applied Fluid Mechanics, 14, (2021), 499-513.
[14]. Geest J.P.V., Sacks M.S., Vorp D.A., “A planar biaxial constitutive relation for the luminal layer of
intraluminal thrombus in abdominal aortic aneurysms”, Journal of Biomechanics, 39, (2006), 2347-2354.
[15]. Mutlu O., Salman H.E., Yalcin H.C., Olcay A.B., “Fluid flow characteristics of healthy and calcified aortic
valves using three-dimensional lagrangian coherent structures Analysis”, Fluids, 6, (2021), 203.
[1]. Mutlu O, Salman H.E., Al-Thani H., El-Menyar A., Qidwai U.A., Yalcin H.C., “How does hemodynamics affect
rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters,
time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative
residence time”, Computers in Biology and Medicine, 154, (2023), 106609.
[2]. Bengtsson H., Bergqvist D., “Ruptured abdominal aortic aneurysm: a population-based study”, Journal of
Vascular Surgery, 18, (1993), 74-80.
[3]. Kontopodis N., Metaxa E., Papaharilaou Y., Tavlas E., Tsetis D., Ioannou C., “Advancements in identifying
biomechanical determinants for abdominal aortic aneurysm rupture” Vascular, 23, (2014), 65-77.
[4]. Salman H.E., Ramazanli B., Yavuz M.M., Yalcin H.C., “Biomechanical investigation of disturbed
hemodynamics-induced tissue degeneration in abdominal aortic aneurysms using computational and
experimental techniques”, Frontiers in bioengineering and biotechnology, 7, (2009), 111.
[5]. Hafez H., Druce P.S., Ashton H.A., “Abdominal aortic aneurysm development in men following a “normal”
aortic ultrasound scan”, European Journal of Vascular and Endovascular Surgery, 36, (2008), 553-558.
[6]. Arslan A.C., Salman H.E., “Effect of intraluminal thrombus burden on the risk of abdominal aortic
aneurysm rupture”, Journal of Cardiovascular Development and Disease, 10, (2023), 233.
[8]. Chaikof E.L., Brewster D.C., Dalman R.L., Makaroun M.S., Illig K.A., Sicard G.A., Timaran C.H., Upchurch Jr G.R.,
Veith F.J., “The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice
guidelines” Journal of Vascular Surgery, 50, (2009), 2-49.
[9]. Kalipcilar A., Salman H.E., “Hemodynamic effects of intraluminal thrombus burden in an idealized
abdominal aortic aneurysm”, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 45,
(2023), 508.
[10]. Les A.S., Shadden S.C., Figueroa C.A., Park J.M., Tedesco M.M., Herfkens R.J., Dalman R.L., Taylor C.A.,
“Quantification of Hemodynamics in Abdominal Aortic Aneurysms During Rest and Exercise Using Magnetic
Resonance Imaging and Computational Fluid Dynamics”, Annals of Biomedical Engineering, 38, (2010), 1288-
1313.
[11]. Salman H.E., “Numerical modeling of the sound generated on an intracranial aneurysm using
computational fluid dynamics”, Düzce University Journal of Science & Technology, 11, (2023), 908-921.
[13]. Salman H.E., Yalcin H.C., “Computational investigation of the effect of wall thickness on rupture risk in
abdominal aortic aneurysms”, Journal of Applied Fluid Mechanics, 14, (2021), 499-513.
[14]. Geest J.P.V., Sacks M.S., Vorp D.A., “A planar biaxial constitutive relation for the luminal layer of
intraluminal thrombus in abdominal aortic aneurysms”, Journal of Biomechanics, 39, (2006), 2347-2354.
[15]. Mutlu O., Salman H.E., Yalcin H.C., Olcay A.B., “Fluid flow characteristics of healthy and calcified aortic
valves using three-dimensional lagrangian coherent structures Analysis”, Fluids, 6, (2021), 203.
Arslan, A. C., & Salman, H. E. (2024). Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm. MANAS Journal of Engineering, 12(1), 34-38. https://doi.org/10.51354/mjen.1220416
AMA
Arslan AC, Salman HE. Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm. MJEN. June 2024;12(1):34-38. doi:10.51354/mjen.1220416
Chicago
Arslan, Aykut Can, and Hüseyin Enes Salman. “Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm”. MANAS Journal of Engineering 12, no. 1 (June 2024): 34-38. https://doi.org/10.51354/mjen.1220416.
EndNote
Arslan AC, Salman HE (June 1, 2024) Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm. MANAS Journal of Engineering 12 1 34–38.
IEEE
A. C. Arslan and H. E. Salman, “Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm”, MJEN, vol. 12, no. 1, pp. 34–38, 2024, doi: 10.51354/mjen.1220416.
ISNAD
Arslan, Aykut Can - Salman, Hüseyin Enes. “Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm”. MANAS Journal of Engineering 12/1 (June 2024), 34-38. https://doi.org/10.51354/mjen.1220416.
JAMA
Arslan AC, Salman HE. Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm. MJEN. 2024;12:34–38.
MLA
Arslan, Aykut Can and Hüseyin Enes Salman. “Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm”. MANAS Journal of Engineering, vol. 12, no. 1, 2024, pp. 34-38, doi:10.51354/mjen.1220416.
Vancouver
Arslan AC, Salman HE. Computational Hemodynamic Analysis of a Patient Specific Abdominal Aortic Aneurysm. MJEN. 2024;12(1):34-8.