Agomelatine-induced elevation of liver enzymes

Year 2013, , 41 - 3, 01.01.2013

Gülçin Elboğa Feridun Bülbül Gökay Alpak Ahmet Ünal Haluk Savaş

https://doi.org/10.5455/jmood.20121105064251

Abstract

Major depression is one of the most frequently seen psychiatric disorders. Classical antidepressant treatments might be insufficient in treating all symptoms of of depression. Therefore, antidepressant treatments which work through different mechanisms have been developed. One of these therapies is agomelatine. Agomelatine is a drug which is a synthetic analogue of melatonin hormone. Melatonin works by stimulating the activities of MT1 and MT2 receptors and inhibiting the activity of serotonin 5HT2C receptor. It is recommended to be cautious in patients taking agomelatine in terms of liver enzyme elevation. In this case report, agomelatine-induced elevation of liver enzymes and the treatment process will be presented.

Keywords

agomelatine, elevated liver enzymes, major depression

Agomelatin kullanımına bağlı gelişen karaciğer enzim yüksekliği

Abstract

Majör depresyon psikiyatrik hastalıklar içinde en sık görülen hastalıklardan biridir. Klasik antidepresan tedaviler depresyonun tüm belirtilerini tedavi etmekte yetersiz kalabilmektedir. Bundan dolayı farklı mekanizmalarla etki eden antidepresan tedaviler geliştirilmeye başlanmıştır. Bu tedavilerden biride agomelatindir. Agomelatin melatonin hormonunun sentetik analoğu olan bir ilaçtır. Melatonin MT1 ve MT2 reseptörlerinin aktivitesini uyararak ve serotonin 5HT2C reseptör aktivitesini inhibe ederek etki gösterir. Agomelatin kullanan hastalarda karaciğer enzim yüksekliği açısından dikkatli olunması önerilmektedir. Bu olgu sunumunda agomelatin’e bağlı gelişen karaciğer enzim yüksekliği ve tedavi süreci sunulacaktır.

Keywords

agomelatin, karaciğer enzim yüksekliği, majör depresyon

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