Agomelatine-induced elevation of liver enzymes

Abstract

Major depression is one of the most frequently seen psychiatric disorders. Classical antidepressant treatments might be insufficient in treating all symptoms of of depression. Therefore, antidepressant treatments which work through different mechanisms have been developed. One of these therapies is agomelatine. Agomelatine is a drug which is a synthetic analogue of melatonin hormone. Melatonin works by stimulating the activities of MT1 and MT2 receptors and inhibiting the activity of serotonin 5HT2C receptor. It is recommended to be cautious in patients taking agomelatine in terms of liver enzyme elevation. In this case report, agomelatine-induced elevation of liver enzymes and the treatment process will be presented.

Keywords

• agomelatine, elevated liver enzymes, major depression

Agomelatin kullanımına bağlı gelişen karaciğer enzim yüksekliği

Öz

Majör depresyon psikiyatrik hastalıklar içinde en sık görülen hastalıklardan biridir. Klasik antidepresan tedaviler depresyonun tüm belirtilerini tedavi etmekte yetersiz kalabilmektedir. Bundan dolayı farklı mekanizmalarla etki eden antidepresan tedaviler geliştirilmeye başlanmıştır. Bu tedavilerden biride agomelatindir. Agomelatin melatonin hormonunun sentetik analoğu olan bir ilaçtır. Melatonin MT1 ve MT2 reseptörlerinin aktivitesini uyararak ve serotonin 5HT2C reseptör aktivitesini inhibe ederek etki gösterir. Agomelatin kullanan hastalarda karaciğer enzim yüksekliği açısından dikkatli olunması önerilmektedir. Bu olgu sunumunda agomelatin’e bağlı gelişen karaciğer enzim yüksekliği ve tedavi süreci sunulacaktır.

Anahtar Kelimeler

• agomelatin, karaciğer enzim yüksekliği, majör depresyon

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