A study of leukocyte and platelet activity in patients with suicide attempt related to acute stres reaction

Abstract

Aim: Acute stress reaction (ASR) is often seen with depression, and stress-related hormones may play an important role in acute arterial thrombosis by increasing platelet aggregation. To the best of our knowledge, no study has examined leukocyte and platelet counts following a suicide attempt with ASR. Method: The present study examined blood leukocyte, platelet and mean platelet volume (MPV) levels. In addition, we examined the factors affecting these parameters. Data for patients who were admitted to the emergency room and evaluated by same psychiatrist after a suicide attempt were obtained from the health registries. Controls were selected from all residents living in the same area. Using a case-control design, we examined 30 suicide cases and 33 controls matched for gender and age. Results: The 30 subjects diagnosed with ASR related suicide showed increased white blood cell counts but similar platelet counts and mean platelet volume compared with controls. At follow-up, the platelet count was lower in patients than in controls (p= 0.001), which was related to suicide attempts by using anti-depressants (p= 0.003). Conclusion: ASR did not increase platelet count or MPV, but we found an increase in leukocyte counts following ASR. Additionally, our study supported the antiplatelet effect of antidepressant medications.

Keywords

• acute stress reaction, suicide, platelet, leucocyte, drugs, antidepressant, analgesic

Akut stres reaksiyonu ile ilişkili olarak intihar girişiminde bulunan hastalarda lökosit ve trombosit aktiviteleri üzerine bir çalışma

Öz

Amaç: Akut stres reaksiyonu (ASR) sıklıkla depresyonla birlikte görülür ve stresle ilişkili hormonlar trombosit birikimiyle ilişkili arteriyel trombozda önemli rol oynarlar. Bilgimize göre ASR ile ilişkili bir intihar girişimi sonrasında lökosit ve trombosit sayımını değerlendiren çalışma yoktur. Yöntem: Bu çalışmada kan lökosit, trombosit ve ortalama trombosit hacim (MPV) düzeyleri incelendi. İlave olarak, bu parametreleri etkileyen etmenler değerlendirildi. Acile başvuran ve intihar girişimi sonrasında aynı psikiyatrist tarafından değerlendirilen hastalara ait veriler toplandı. Aynı bölgede yaşayan sağlıklı örneklem grubu kontrol grubu olarak kabul edildi. Vaka-kontrol çalışması olarak dizayn edilen bu çalışmada 30 intihar girişimi vakası ve yaş ve cinsiyet olarak uygun 33 kontrol vakası analize tabi tutuldu. Bulgular: İntiharla ilişkili ASR tanısı olan 30 kişinin kontrollerle karşılaştırılmasında kan sonuçları artmış lökosit düzeyi saptanırken trombosit sayısı ve MPV düzeyleri benzer bulundu. Takipte, trombosit düzeyi hasta grubunda daha düşük düzeylerde bulundu (p=0.001) ve bu düşüklük intihar amaçlı antidepresan kullanımı ile ilişkiliydi (p=0.003). Sonuç: ASR sonrasında trombosit sayısı veya MPV düzeyi artmadı, fakat lökosit sayısında artış gözlemlendi. İlaveten, çalışmamız antidepresan ilaçlarla ilişkili anti-trombosit etkinin varlığını da desteklemekteydi.

Anahtar Kelimeler

• akut stres reaksiyonu, intihar, trombosit, lökosit, ilaçlar, anti-depresan, analjezik

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