Persistent cerebellar syndrome due to lithium treatment: a case report

Abstract

We report the case of a 23-year-old man with bipolar disorder who developed permanent cerebellar damage of lithium intake within therapeutic ranges. Cerebellar symptoms such as dysarthria, ataxia, and tremor developed 1 year after the beginning of lithium. Two years later, cerebellar signs and symptoms were found to be permanent in the patient. Cerebellar syndrome was most probably due to lithium neurotoxicity, which was associated with the administration of antipsychotic.

Keywords

• lithium, Cerebellar syndrome, permanent neurotoxicity

Lityum tedavisine bağlı gelişen kalıcı serebellar sendrom: Olgu sunumu

Öz

Bu yazımızda iki uçlu bozukluğu olan 23 yaşındaki bir erkek hastada normal aralıktaki serum lityum düzeylerine rağmen kalıcı serebellar sendrom gelişen bir olguyu sunduk. Lityum tedavisi başlanmasından 1 yıl sonra hastada dizartri, ataksi, tremor gibi serebellar bulgular gelişti. 2 yıl sonra, hastanın serebellar bulgularının kalıcı olduğu gözlendi. Olgumuzda gelişen serebellar sendrom en büyük olasılıkla lityum tedavisiyle birlikte antipsikotik kullanılmasına bağlıdır.

Anahtar Kelimeler

• lityum, serebellar sendrom, kalıcı nörotoksisite

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