Bipolar disorder and suicidal behaviour

Abstract

Suicide risk in people with bipolar disorder is an important public health concern. The present literature shows that, patients with bipolar disorders are at higher risk of attempted and completed suicide than that of patients with unipolar majör depression. Among patients with different clinical manifestations of major mood disorders (unipolar major depression, bipolar I and bipolar II disorder), bipolar patients in general, and bipolar II subjects in particular carry the highest risk of suicide. The aim of this paper is to analyse the relationship between different forms of bipolar disorder and suicidal behaviour.

Keywords

• bipolar disorder, suicidal behaviour, risk factors

İki uçlu bozukluk ve intihar davranışı

Öz

İki uçlu bozukluğu olan kişilerdeki intihar riski önemli bir halk sağlığı sorunudur. Mevcut literatür, iki uçlu bozukluklu hastalarda intihar girişimi ve tamamlanmış intihar girişimi riskinin, unipolar majör depresyonlu hastalardan daha yüksek olduğunu göstermektedir. Majör duygudurum bozukluklarına ait farklı klinik görümlü (unipolar majör depresyon, iki uçlu I ve iki uçlu II) hastalar arasında, genel olarak iki uçlu hastalarda ve özellikle iki uçlu II olguları en yüksek intihar riski taşımaktadırlar. Bu yazının amacı iki uçlu bozukluğun farklı formları ile intihar davranışı arasındaki ilişkiyi analiz etmektir.

Anahtar Kelimeler

• iki uçlu bozukluk, intihar davranışı, risk faktörleri

References

1. Raja M, Azzoni A. Suicide attempts: differences between unipolar and bipolar patients and among groups with different lethality risk. J Affect Disord. 2004;82:437-42.
2. Oquendo MA, Waternaux C, Brodsky B, et al. Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters. J Affect Disord. 2000;59:107-17.
3. Rihmer Z, Kiss K. Bipolar disorders and suicidal behaviour. Bipolar Disord. 2002;4:21-5.
4. Song JY, Yu HY, Kim SH, et al. Assessment of Risk Factors Related to Suicide Attempts in Patients With Bipolar Disorder. J Nerv Ment Dis. 2012;200:978-84.
5. Finseth PI, Morken G, Andreassen OA, et al. Risk factors related to lifetime suicide attempts in acutely admitted bipolar disorder inpatients. Bipolar Disord. 2012;14:727-34.
6. Jamison KR. Suicide and bipolar disorder. J Clin Psychiatry. 2000;61 Suppl 9:47Abreu LN, Lafer B, Baca-Garcia E, et al. Suicidal ideation and suicide attempts in bipolar disorder type I: an update for the clinician. Rev Bras Psiquiatr. 2009;31:271-80.
7. Mahon K, Burdick KE, Wu J, et al. Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study. Bipolar Disord. 2012;14:80-9.
8. Simon GE, Hunkeler E, Fireman B, et al. Risk of suicide attempt and suicide death in patients treated for bipolar disorder. Bipolar Disord. 2007;9:526

9. Valtonen HM, Suominen K, Mantere O, et al. Prospective study of risk factors for attempted suicide among patients with bipolar disorder. Bipolar Disord. 2006;8:576-85.
10. Baldessarini RJ, Tondo L, Hennen J. Effects of lithium treatment and its discontinuation on suicidal behavior in bipolar manic-depressive disorders. J Clin Psychiatry. 1999;60:77-84.
11. Hesdorffer DC, Kanner AM. The FDA alert on suicidality and antiepileptic drugs: Fire or false alarm? Epilepsia. 2009;50:978-86.