Treatment differences between bipolar disorder I and II depression

Abstract

The clinical phenomenology of bipolar 1 and 2 depressions may be different. Whether treatments of bipolar 1 and bipolar 2 depressions differ is a matter of dispute. There is yet not enough evidence regarding the treatment of bipolar 2 depression, however, emerging data show that there must be some difference in the treatment of these two conditions. One should be cautious especially with antidepressants.

Keywords

• bipolar disorder, depression, treatment

İki uçlu bozukluk 1 ve iki uçlu bozukluk 2 depresyon tedavisi arasındaki farklar

Öz

İki uçlu bozukluk 1 ve 2 depresyonları, klinik açıdan farklılıklar gösterebilmektedir. İki uçlu bozukluk 2 ve iki uçlu bozukluk 1 depresyonların tedavisi arasındaki farklar ise tartışmalı bir alandır. Henüz İki uçlu bozukluk 2 depresyon tedavisi konusunda yeterince kanıt birikmemişse de ilk veriler her iki durumun tedavisinde farklar olması gerektiğini düşündürmektedir. Özellikle antidepresan kullanımı konusunda dikkatli olmak gerekmektedir.

Anahtar Kelimeler

• iki uçlu bozukluk, depresyon, tedavi

References

1. Goodwin FK, Jamison KR Manic-Depressive iIllness: Bipolar disorders and recurrent depression. 2nd edition.. New York: Oxford University Press 2007.
2. Malhi GS, Adams D. & Berk M. . Medicating mood with maintenance in mind: bipolar depression pharmacotherapy. Bipolar Disorders.2009;11: 55-76.
3. Schwartz HA, Thase ME Pharmacotherapy for the treatment of acute bipolar II depression: current evidence. Journal of Clinical Psychiatry 2011;72: 356-66.
4. Malhi GS, Bargh DM, Cashman E, Frye MA, Gitlin M. The clinical management of bipolar disorder complexity using a stratified model. Bipolar Disorders 2012;14:66-89.
5. Akiskal HS, Benazzi F. Optimizing the detection of bipolar II disorder in outpatient private practice : toward a systematization of clinical diagnostic wisdom. J Clin Psychiatry 2005;66: 914-921.
6. Akiskal HS, Benazzi F. The DSM-IV and ICD-10 categories of recurrent (major) depressive and bipolar II disorders: evidence that they lie on a dimensional spectrum. J Affect Disord 2006;92: 45-54.
7. Pacchiarotti I, Valenti M, Colom F, Rosa AR, Nivoli AM, Murru A, SanchezMoreno J, Vieta E. Differential outcome of bipolar patients receiving antidepressants monotherapy versus combination with an antimanic drug. J Affect Disord 2011: 129; 321-6.
8. Sachs GS, Nierenberg AA, Calabrese JR, Marangell LB, Wisniewski SR, Gyulai L, Friedman ES, Bowden CL, Fossey MD, Ostacher MJ, Ketter TA, Patel J, Hauser P, Rapport D, Martinez JM, Allen MH, Miklowitz DJ, Otto MW, Dennehy EB & Thase, ME. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N. Engl. Journal of Med 2007; 356;1711-2. Malhi GS, Adams D, Lampe L, Paton M, O’Connor N, Newton LA, Walter, G, Taylor A, Porter R, Mulder RT & Berk M . Clinical practice recommendations for bipolar disorder . Acta Psychiatr Scand 2009:11;, 27El-Mallakh RS, Karippot A, Ghaemi SN . Antidepressants in bipolar depression. In El-Mallakh RS, Ghaemi SN(editor) Bipolar depression: a comprehensive guide. London: American Psychiatric Publishing.2006: 167-185).

9. Suppes T, Dennehy EB, Hirschfeld RM, Altshuler LL, Bowden CL, Calabrese JR, Crismon ML, Ketter TA, Sachs GS, Swann AC. The texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder. J Clin Psychiatry 2005: 66; 870-886.
10. Tohen M, Vieta E, Calabrese J. Efficacy of olanzapine and olanzapine/ fluoxetine combination in the treatment of bipolar I depression. Arch. Gen. Psychiatry 2003.