Serum resistin levels and metabolic changes in bipolar disorder

Abstract

Aim: Metabolic changes in bipolar disorder appear to be among the cluster of disturbances that have insulin resistance as a common etiologic factor. Several recently discovered adipokines such as resistin and visfatin play a role in the pathogenesis of insulin resistance. In this study we aimed to evaluate the association between serum resistin levels and metabolic changes in bipolar disorder. Method: Sixty euthymic bipolar I disorder patients, of 29 on mood stabilizer (MS) (lithium, valproic acid, carbamazepine, and lamotrigine) treatment and of 31 on atypical antipsychotic (AA) (risperidone, quetiapine and olanzapine) treatment for at least 3 months, were enrolled. The control group consisted of 27 healthy members who have had similar distributions of age, sex, and BMI with the patients. Resistin, glucose, triglycerides, and high density lipoprotein (HDL) levels were measured in all groups. Results: Resistin levels were found to be significantly high in bipolar patients than that in the controls. However, when metabolic parameters were considered resistin levels were not significantly different between the patient and control groups (p>0.05). Conclusion: Despite serum resistin levels were high in bipolar patients, we did not find any association between metabolic disturbances and treatment modalities.

Keywords

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İkiuçlu bozuklukta serum rezistin düzeyleri ve metabolik değişiklikler

Öz

Amaç: İki uçlu bozuklukta (İUB) görülen metabolik değişiklikler insülin direnci gibi çeşitli etyolojik etmenlerin gösterildiği hastalıkların bir kümesi olarak görünmektedir. İnsülin direncinin patogenezinde rezistin, visfatin gibi adipokinlerin rolü keşfedilmiştir. Bu çalışmada İUB’de metabolik değişiklikler ve serum rezistin seviyeleri arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Yöntem: İUB tip I ötimik dönemdeki hastalardan en az 3 ay süre ile atipik antipsikotik (risperidon, ketiapin, olanzapin) almış 31 hasta ile mizaç düzenleyici (lityum, valproik asit, karbamazepin, lamotrijin) almış 29 hasta çalışmaya dahil edildi. Kontrol grubu 27 sağlıklı kişiden oluşmakta idi. Rezistin, glukoz, trigliserit ve HDL tüm gruplarda ölçüldü. Bulgular: İUB hasta grubunda kontrol grubuna kıyasla daha yüksek rezistin düzeyleri saptanmasına rağmen metabolik parametrelere bakıldığında serum rezistin seviyeleri açısından hastalar ve kontrol grubu arasında farklılık bulunmamıştır. Sonuç: Serum rezistin seviyeleri İUB hastalarında yüksek olmasına rağmen bu durumun metabolik değişiklikler ve tedavi modaliteleri ile ilişkisi bulunamamıştır.

Anahtar Kelimeler

• iki uçlu bozukluk, rezistin, metabolik değişiklik

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