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Innovations in treatment of treatment-resistant unipolar depression

Year 2013, Volume: 3 Issue: 5, 0 - 0, 01.05.2013

Abstract

Today, depression is one of the most important health problems. Despite the progress made in the treatment of depression, treatment resistance and chronicity still remains a major problem. New research and the new treatments on the etiology and treatment of depression are directed from “genetic versus environmental roles to genetic-environmental interactions”, from “chemical imbalance to inflammatory processes”, from “neurotransmitters to neuroplasticity and neurotrophic factors”, from “serotonin, norepinephrine and dopamine to glutamate”, from “pills to intravenous infusions”, from “monotherapy to augmentation strategies”, from “pharmacotherapy to neuromodulation”. In the treatment of treatment-resistant unipolar depression (TRUD) “switch to another drug from the same group, choosing a drug from different groups, add another drug to available drug, electroconvulsive therapy” as is known methods beside recently “repetitive transmagnetic stimulation (rTMS), deep brain stimulation (DBS), vagal nerve stimulation (VNS)” such non-pharmacological treatments have been accepted and the use of them has become common.

References

  • Nasrallah HA. Innovative approaches to treatment-resistant depression. Current Psychiatry (Online) 2012;11.
  • Cattaneo A, Bocchio-Chiavetto L, Zanardini R, et al. Reduced peripheral brain derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. Int J Neuropsychopharmacol 2010;13:103-8.
  • Berman RM, Cappiello A, Anand A, Oren DA,et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000;47:351–4.
  • Zarate CA, Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methylD-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatr 2006;63:856–64.
  • Sigalas PD et al. Metyrapone in treatment-resistant Depression. Ther Adv Psychopharmacol 2012;2:139–49.
  • Gagné GG Jr, Furman MJ, Carpenter LL, et al. Efficacy of continuation ECT and antidepressant drugs compared to long term antidepressants alone in depressed patients. Am J Psychiatry 2000;157: 1960-5.
  • Fitzgerald PB, Brown TL, Marston NA, et al. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebocontrolled trial. Arch Gen Psychiatry 2003;60:1002.
  • Avery DH, Holtzheimer PE 3rd, Fawaz W, et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biol Psychiatry 2006;59:187.
  • O’Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62:1208.
  • Durmaz O. Tedaviye dirençli tek uçlu major depresif bozuklukta rTMSrTMU (Tekrarlayıcı transkraniyal manyetik uyarım) tedavisinin etkinliği ve tedaviye cevabın klinik değişkenlerle ilişkisi: bir doğal izlem çalışması. GATA H.Paşa Eğt. Hast. Uzmanlık tezi. İstanbul 2012.
  • Peng H, Zheng H, Li L, Liu Jet al. High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression. J Affect Disord 2012;136:249-57.
  • Rush AJ, George MS, Sackeim HA, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry 2000;47:276-86.
  • Rush AJ, Marangell LB, Sackeim HA, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry 2005;58:347.
  • Pardo JV, Sheikh SA, Schwindt GC, et al. Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism. Neuroimage 2008;42:879-89.
  • Lozano AM, Mayberg HS, Giacobbe P, et al. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry 2008;64:461.
  • Malone DA Jr, Dougherty DD, Rezai AR, et al. Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry 2009;65:267.
  • Kayser S, Bewernick BH, Grubert C, et al. Antidepressant effects, of magnetic seizure therapy and electroconvulsive therapy, in treatmentresistant depression. J Psychiatr Res 2011;45:569.
  • White PF, Amos Q, Zhang Y, et al. Anesthetic considerations for magnetic seizure therapy: a novel therapy for severe depression. Anesth Analg 2006;103:76.

Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler

Year 2013, Volume: 3 Issue: 5, 0 - 0, 01.05.2013

Abstract

Günümüzde en önemli sağlık sorunlarından biri olan depresyonun tedavisinde kaydedilen gelişmelere rağmen, tedaviye direnç ve kronikleşme hala büyük bir sorundur. Depresyonun etyolojisi ve tedavisinde yeni araştırmalar ve yeni tedaviler “genetik ya da çevre rollerinden genetik-çevre etkileşimine, kimyasal dengesizlikten inflamatuvar süreçlere, nörotransmitterlerden nöroplastisiteye ve nörotrofik faktörlere, serotonin, norepinefrin ve dopaminden glutamata, haplardan intravenöz infüzyonlara, monoterapiden güçlendirme stratejilerine, farmakoterapiden nöromodülasyona” yönelmiştir. Tedaviye dirençli tek uçlu depresyon (TDD) tedavisinde “aynı gruptan başka bir ilaca geçme, farklı gruptan bir ilaç seçme, mevcut ilaca başka bir ilaç ekleme, elektrokonvulzif tedavi” gibi bilinen yöntemlerin yanında son zamanlarda “tekrarlayan transmanyetik uyarımı (rTMS), derin beyin uyarımı (DBS), vagal sinir uyarımı (VNS)” gibi farmakolojik olmayan tedaviler de giderek kabul görmeye ve kullanımı yaygınlaşmaya başlamıştır.

References

  • Nasrallah HA. Innovative approaches to treatment-resistant depression. Current Psychiatry (Online) 2012;11.
  • Cattaneo A, Bocchio-Chiavetto L, Zanardini R, et al. Reduced peripheral brain derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. Int J Neuropsychopharmacol 2010;13:103-8.
  • Berman RM, Cappiello A, Anand A, Oren DA,et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000;47:351–4.
  • Zarate CA, Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methylD-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatr 2006;63:856–64.
  • Sigalas PD et al. Metyrapone in treatment-resistant Depression. Ther Adv Psychopharmacol 2012;2:139–49.
  • Gagné GG Jr, Furman MJ, Carpenter LL, et al. Efficacy of continuation ECT and antidepressant drugs compared to long term antidepressants alone in depressed patients. Am J Psychiatry 2000;157: 1960-5.
  • Fitzgerald PB, Brown TL, Marston NA, et al. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebocontrolled trial. Arch Gen Psychiatry 2003;60:1002.
  • Avery DH, Holtzheimer PE 3rd, Fawaz W, et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biol Psychiatry 2006;59:187.
  • O’Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62:1208.
  • Durmaz O. Tedaviye dirençli tek uçlu major depresif bozuklukta rTMSrTMU (Tekrarlayıcı transkraniyal manyetik uyarım) tedavisinin etkinliği ve tedaviye cevabın klinik değişkenlerle ilişkisi: bir doğal izlem çalışması. GATA H.Paşa Eğt. Hast. Uzmanlık tezi. İstanbul 2012.
  • Peng H, Zheng H, Li L, Liu Jet al. High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression. J Affect Disord 2012;136:249-57.
  • Rush AJ, George MS, Sackeim HA, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry 2000;47:276-86.
  • Rush AJ, Marangell LB, Sackeim HA, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry 2005;58:347.
  • Pardo JV, Sheikh SA, Schwindt GC, et al. Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism. Neuroimage 2008;42:879-89.
  • Lozano AM, Mayberg HS, Giacobbe P, et al. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry 2008;64:461.
  • Malone DA Jr, Dougherty DD, Rezai AR, et al. Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry 2009;65:267.
  • Kayser S, Bewernick BH, Grubert C, et al. Antidepressant effects, of magnetic seizure therapy and electroconvulsive therapy, in treatmentresistant depression. J Psychiatr Res 2011;45:569.
  • White PF, Amos Q, Zhang Y, et al. Anesthetic considerations for magnetic seizure therapy: a novel therapy for severe depression. Anesth Analg 2006;103:76.
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Servet Ebrinç This is me

Publication Date May 1, 2013
Published in Issue Year 2013 Volume: 3 Issue: 5

Cite

APA Ebrinç, S. (2013). Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler. Journal of Mood Disorders, 3(5).
AMA Ebrinç S. Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler. Journal of Mood Disorders. May 2013;3(5).
Chicago Ebrinç, Servet. “Tedaviye dirençli Tek uçlu Depresyonun Tedavisinde Yenilikler”. Journal of Mood Disorders 3, no. 5 (May 2013).
EndNote Ebrinç S (May 1, 2013) Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler. Journal of Mood Disorders 3 5
IEEE S. Ebrinç, “Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler”, Journal of Mood Disorders, vol. 3, no. 5, 2013.
ISNAD Ebrinç, Servet. “Tedaviye dirençli Tek uçlu Depresyonun Tedavisinde Yenilikler”. Journal of Mood Disorders 3/5 (May 2013).
JAMA Ebrinç S. Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler. Journal of Mood Disorders. 2013;3.
MLA Ebrinç, Servet. “Tedaviye dirençli Tek uçlu Depresyonun Tedavisinde Yenilikler”. Journal of Mood Disorders, vol. 3, no. 5, 2013.
Vancouver Ebrinç S. Tedaviye dirençli tek uçlu depresyonun tedavisinde yenilikler. Journal of Mood Disorders. 2013;3(5).