Histopathological Review of Male Breast Cancer Cases

Abstract

Objective: Male breast cancer (MBC) accounts for less than 1% of all breast cancer diagnoses and all cancer cases in men. Methods: We included 33 MBC cases and analyzed histopathological features and survival data. Results: The mean age was 63.5, mean tumor diameter was 3 cm. Central quadrants (69.2%) was most common localization, invasive ductal carcinoma (75.8%) was most common histological subtype. Most of the cases (78.6%) were grade 2. Nipple involvement was noted in 9, tumor necrosis in 9, perineural invasion in 15, dermal lymphatic emboli in 10 cases. Nearly half of the cases (45.5%) showed lymph node metastasis. There was statistically significant relation between lymph node metastasis and stromal lymphocyte response, tumor necrosis (p=0.008, p=0.013) also between grade and dermal lymphatic emboli (p=0.04). Non-tumoral parenchymal findings were columnar cell lesions (CCL), (n: 5) and gynaecomastia (n: 3). Majority of the cases showed estrogen receptor (90.9%) and progesterone receptor (77.2%) positivity. Overall survival analysis showed significant results between grade (p=0.008), lymph node metastasis (p=0.03), dermal lymphatic tumor emboli (p=0.02), nipple involvement (p=0.02) and survival. Conclusions: Our results showed good correlation with literature data in terms of histopathological features and prognostic factors. Confidential data about etiological and prognostic factors will be collected through these reports showing institutional experiences. The significance of CCL in MBC etiology, the impact of intratumoral stromal lymphocyte response, hormone receptor-HER2 status on survival should be clarified in larger series

Keywords

• Male breast cancer, Prognosis, Histopathology

Histopathological Review of Male Breast Cancer Cases

Öz

References

1. Agrawal A, Ayantunde AA, Rampaul R, Robertson JF. Male breast cancer: a review of clinical management. Breast cancer research and treatment. 2007;103(1):11-21.
2. Ni YB, Mujtaba S, Shao MM, Lacambra M, Tsang JY, Chan SK, et al. Columnar cell-like changes in the male breast. Journal of clinical pathology. 2014;67(1):45-8.
3. Verschuur-Maes AH, Kornegoor R, de Bruin PC, Oudejans JJ, van Diest PJ. Do columnar cell lesions exist in the male breast? Histopathology. 2014;64(6):818-25.
4. Nahleh Z, Girnius S. Male breast cancer: a gender issue. Nature clinical practice Oncology. 2006;3(8):428-37.
5. Hill TD, Khamis HJ, Tyczynski JE, Berkel HJ. Comparison of male and female breast cancer incidence trends, tumor characteristics, and survival. Annals of epidemiology. 2005;15(10):773-80.
6. Rathore AS, Kumar S, Konwar R, Srivastava AN, Makker A, Goel MM. Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast. Indian journal of cancer. 2013;50(3):239-44.
7. Giordano SH. A review of the diagnosis and management of male breast cancer. The oncologist. 2005;10(7):471-9
8. Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma. Canadian journal of surgery Journal canadien de chirurgie. 2002;45(4):296-302.

9. Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
10. License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
11. provided the original work is properly cited.