Anaplastic Childhood Meningioma in a 16-Year-Old Boy

Abstract

Introduction: Meningiomas account for 0.4-4.6% of all primary brain tumors in children. Childhood meningiomas have several different characteristics than those occuring in adults. Case: Here we report a 16 year old male presented with long-standing headache and incipient weakness on the left side. Magnetic resonance images revealed a 65x47x37 mm sized, right sided frontoparietal parasagittal extraaxial mass. Histopathologic examination showed monotonous, small cells with oval/round nucleus forming whorl like structures. Tumor showed high mitotic index and Ki67 proliferation rate around 30%. Immunohistochemically tumor cells were positive with EMA, vimentin, bcl-2, progesterone receptor. The final diagnosis according to histopathological, radiological and immunohistochemical findings was anaplastic meningioma. Conclusion: High-grade meningiomas are rare in children. Appropriate grading is important, as high grade tumors with high proliferation index are associated with less favorable clinical outcomes and warrant more radical treatment.

Keywords

• Meningioma, Childhood, High grade

Anaplastic Childhood Meningioma in a 16-Year-Old Boy

Abstract

References

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