Effects of sevoflurane and desflurane on the blood and plasma viscosity

Abstract

The purpose of present study was to compare the effects of desflurane and sevoflurane on blood viscosity in three different shear rates and plasma viscosity. Forty male patients, ASAI-II, undergone tympanoplasty were included in this study. Patients were randomly categorized as anaesthetized either with sevoflurane or desflurane. Anaesthesia was maintained with inspiratory concentrations of sevoflurane 1-1.5 MAC or desflurane. The samples were taken for hemorheological and biochemical examinations before induction of anaesthesia (initial time) and at 60^th and 120^th min of the operation. Blood viscosities were measured by rotational viscometer. Plasma viscosity was measured by capillary viscometer. Patients receiving desflurane showed steady decrease at 23 1/sec shear rate at 60^th and 120^th min and in blood viscosity at 115 1/sec shear rate in 120^th min. Statistically significant decrease in the level of plasma viscosity was observed in the patient group anesthetized with desflurane, between initial time vs 60^th min (p<0.01), initial time vs 120^th min. (p<0.01). Desflurane produced stable effects on the blood circulation. The differences in the blood viscosity should not be overlooked.

Keywords: Desflurane, Sevoflurane, Blood viscosity, Plasma viscosity

Keywords

• Desflurane, Sevoflurane, Blood viscosity, Plasma viscosity

Effects of sevoflurane and desflurane on the blood and plasma viscosity

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