EFFECT OF PROPOFOL AND MEMANTINE ON ERYTHROCYTE DEFORMABILITY IN DIABETIC RAT MODEL

Abstract

OBJECTIVES: In this study we aimed to investigate the effect of diabetes on erythrocyte deformability (ED) and whether it can be changed by an NMDA antagonist propofol or an NMDA agonist, memantine

BACKGROUND: Several clinical studies showed that ED decreases in diabetes. Recent studies showed that erythrocytes have N-methyl-D-aspartate (NMDA) receptors (NMDA Rec) on their membrane.

METHODS: Thirty rats were allocated to five groups containing 6 rats each. Memantine was given for 30 days to diabetic rats in one group (group DM) single dose propofol injection is added to this regimen in another group (group DP+ memantine) another group received propofol only (group DP). The remaining groups were controls and diabetic controls. ED was measured in each group and compared

RESULTS: The deformability index was significantly increased in the diabetic rats (p<0.0001). However, it was similar in Group DC and DP (p=0.551), Group DC and DM (p=1.000), Group DC and DPM (p=0.176).

CONCLUSION: Neither NMDA antagonist propofol nor NMDA agonist memantine affected the altered red cell rheology in diabetic rat model.

Keywords

• Memantine, propofol, erythrocyte deformability, diabetes mellitus, rat

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