The effects of glycemic control on malondialdehyde modified low-density-lipoprotein-immunglobulin G levels in type 2 diabetics

Abstract

Objective: The aim of this study is investigation of effect of glycemic control on the levels of malondialdehyde-low-density-lipoprotein-immunglobulin G (MDA-LDL-IgG) which is supposed to be positively correlated with myocardial infarction risk in subjects with type 2 diabetes mellitus (DM).

Material and Method: We evaluated the levels of glucose, triglyceride, total cholesterol, high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), hemoglobin A1c (A1C) and MDA-LDL-IgG in subjects with well-controlled DM (W-DM, <7% HbA1c, n=18), poorly-controlled DM (P-DM, >7% HbA1c, n=22) and in non-diabetics (Non-DM, n=15).

Results: There were no significant differences between P-DM and W-DM groups for triglyceride, total cholesterol and LDL-C levels but these tests were significantly low in the Non-DM group compared to other groups (respectively, p=0.002, p<0.001 and p=0.001). There was no significant difference between W-DM and Non-DM groups for MDA-LDL-IgG levels, but in P-DM group they were significantly higher compared to W-DM and Non-DM (p=0.002). There was a positive correlation between A1C andMDA-LDL-IgG levels (r=0.463, p= p=0.001).

Conclusion: These findings suggest that the normalization of blood glucose levels in type 2 diabetics may persuade the reduced rate of the formation of new antigenic epitopes on the LDL via non-enzymatic glycosylation. The regulation of diabetes may be improved by reducing antibody formation against the MDA-LDL although there is no effect on lipid levels. A1C may not only be a good indicator of blood glucose control but also a good predictor for diabetes-related macro vascular complications.

Keywords

• Type 2 diabetes mellitus; A1C; glycemic control; Cholesterol; MDA; LDL

The effects of glycemic control on malondialdehyde modified low-density- lipoprotein-immunglobulin G levels in type 2 diabetics

Öz

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