Effect of heavy metal and some trace element levels on radiotherapy taken breast cancer patients

Abstract

Objective:  The aim of this article is to research the effects of radiotherapy on trace elements and heavy metals in patients with breast cancer. Breast cancer is a common disease worldwide. Breast cancer risk increases with age and occurs at much higher levels in postmenopausal women. During radiation therapy for the treatment of breast cancer, damage to tissue may result. Depending on the treatment technique applied, other areas apart from the treatment area may be affected. For example, the lungs may be negatively affected, resulting in decreased lung capacity. Consequently, free radicals may be formed as a result of oxidative stress incurred due to insufficient lung capacity

Plan and design:  In this review article, approximately 110 articles were consulted.

Result:  Radiotherapy may cause damage to or loss of tissue, and may have negative effects on trace element levels. Consequently, levels of heavy metals and trace elements may be altered during radiotherapy.

Conclusion; An increase in heavy metals leads to greater oxidative stress, which is associated with a higher risk of cancer. Normal levels of Zn may also decrease the risk of cancer.

Keywords

• trace elements; heavy metals; radiation therapy; cancer

Effect of heavy metal and some trace element levels on radiotherapy taken breast cancer patients

Öz

References

1. Seven G., 2010. Meme, Baş boyun ve Mide kanserli hastalarda Radyoterapi öncesi ve sonrası iz elementler ve ağır metal düzeylerinin (Zn, Cu, Pb, Cd, Mn, Mg ve Co) ve bazı biyokimyasal (katalaz ve karbonik anhidraz) parametrelerin incelenmesi. 2010. Yüzüncü Yıl Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Anabilim Dalı, Biyokimya Bilim Dalı (yüksek lisans tezi), Van.
2. Cobanoglu U, Demir H, Sayir F, Duran M, Meran D. Some mineral, trace element and heavy metal concentrations in Lung Cancer. A. Pacific Journal of Cancer Prevention. 2010. 11, 1383-1388.
3. Kollmeier H, Seeman JW, Rothe G, Muller KM, Wittig P. Increased chromium and nickel content in lung tissue and bronchial carcinoma. 1987. Am. J. Ind. Med., 11: 659–669.
4. David M, Ondrej N, Vaclav S, Kamil V, and Jindrich M. Serum levels of selenium, manganese, copper, and iron in colorectal cancer patients. Biological Trace Element Research. 2001. Volume 79, Number 2, Pages 107-114.
5. Cavusoglu K, Cakır AS, Kurtman C. Radyoterapi Gören Akciğer Kanseri Hastaların Plazma İz Element Düzeylerindeki Değişimin Belirlenmesi. F.U. Sag. Bil. Derg. 2008: 22 (4): 211 – 222.
6. Dubova S, Özsaran Z, Kamer S, Haydaroğlu A. Radikal radyoterapi uygulanan lokal ileri evre akciğer, baş-boyun ve serviks kanserlerinde serum selenyum düzeyi ve tedaviye yanıt ile ilişkisi. Türk Onkoloji Dergisi. 2006; 21(3): 107–114.
7. Feng JF, Lu L, Zeng P, Yang H, Luo J, Yang Y, Wang D. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. International journal of clinical oncology. 2012; 17(6):575-83.
8. Huang YL, Sheu JY, Lın TH. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clinical Biochemistry. 1999; 32(2) 131-136.

9. Kuo HW, Chen SF, Wu CC, Chen DR, Lee JH. Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol Trace Elem. Res. 2002; 89:1–11.
10. Toy A. Meme kanserli hastalarda tedavi oncesi ve sonrasi total antioksidan kapasite eser elementler ve lipid peroksidasyonu. 2012. Trakya Üniversitesi Sağlık Bilimleri Enstitusu Biyofizik Anabilim Dali (yuksek lisans tezi). Edirne.
11. Prasad AS, Beck FWJ, Endre L, Handschu W, Kukuruga M, Kumar G. Zinc deficiency affects cell cycle and deoxythymidine kinase (TK) gene expression in HUT-78 cells. J Lab Clin Med. 1996; 128(1): 51–60.
12. Pathak P, Kapil U. Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian J Pediatr. 2004; 71(11):1003-1005.
13. Miller AC, Mog S, McKinney L, Luo L, Allen J, Xu J, and Page N. Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: induction of toxic effects. Carcinogenesis. 2001; 22(1):115–125.
14. Miller AC, Brooks K, Smith J, Page N. Effect of the militarily relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2004; 255(1-2): 247–256.
15. Ilıcin G. Serum copper and magnesium levels in leukemia and malignant Iymphoma. Lancet. 1971; 2(7732):1036-1037.
16. Cobanoglu U, Demir H, Sayir F, Duran M, Meran D. Some mineral, trace element and heavy metal concentrations in Lung Cancer, A. Pacific Journal of Cancer Prevention. 2010; 11,1383-1388.
17. De Palma G, Goldoni M, Catalani S, Carbognani P, Poli D, Mozzoni P, Acampa O, Internullo E, Rusca M, Apostoli P. Metallic elements in pulmonary biopsies from lung cancer and control subjects. Acta Bıomed. 2008; 79 (Suppl 1): 43-51.
18. Kaba M, Pirinçç NÜ, Yüksel MB, Geçit İ, Güneş M, Demir M, Akkoyun HT, Demir H. Serum Levels of Trace Elements in Patients with Testicular Cancers. Int Braz J Urol. 2015; 41: 1101-07.
19. Bilici M, Cim N, Demir H. Examination of preoperative and postoperative levels of rare earth elements (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe) in the blood of ovarian cancer patients. Medical Science and Discovery. 2015, Vol. 2, No. 1, p:139-43.
20. Kaba M, Pirincci N, Yuksel MB, Gecit I, Gunes M, Ozveren H, Eren H, Demir H. Serum levels of trace elements in patients with prostate cancer. A. Pac J Cancer Prev. 2014;15(6): 2625-9.
21. Cunzhi H, Jiexian J, Xianwen Z, Jingang G, Shumin Z, Lili D. Serum and tissue levels of six trace elements and copper/ zinc ratio in patients with cervical cancer and uterine myoma. Biol Trace Elem Res. 2003; 94, 113-22.
22. Yaman M, Kaya G, Simsek M. Comparision of trace elements concentrations in cancerous and noncancerous human endometrial and ovary tissues. Int J Gynecol Cancer. 2007; 17, 220-8.
23. Arslan M, Demir H, Arslan H, Gokalp AS, Demir C. Trace elements, heavy metals and other biochemical parameters in malignant glioma patients. Asian Pac J Cancer Prev. 2011; 12, 447-51.
24. Pirincci N, Gecit I, Gunes M, Kaba M, Tanik S, Yuksel MB, Arslan H, Demir H. Levels of serum trace elements in renal cell carcinoma cases. A. Pac J Cancer Prev. 2013; 14(1):499-502.
25. Arooj B, Ahmed S, Saleem M, Khurshid R, Zia M. Serum trace elements in diagnosis of breast malignancy. J Ayub Med Coll Abbottabad. 2012; 24(2):62-4.
26. Kuo HW, Chen SF, Wu CC, Chen DR, Lee JH. Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol Trace Elem Res. 2002; 89(1):1-11.
27. Gupta SK, Shukla VK, Vaidya MP, Roy SK, Gupta S. Serum trace elements and Cu/Zn ratio in breast cancer patients. J Surg Oncol. 1991; 46(3):178-81.
28. Thomsen C D, and Robinson M F. Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand. Am. J. Clin. Nutr. 1980; 33: 303-323.
29. Moore AB, Shannon J, Chen C, Ohanna WL, Roberta MR, Sharon KL, Minggang L, Helge S, and David BT.Dietary and stored iron as predictors of breast cancer risk: a nested case–control study in Shanghai. Int J Cancer. 2009; 125:1110–1117. 59.
30. Andreini C, Bertini I, Cavallaro G, Gemma LH, Janet MT. Metal ions in biological catalysis: from enzyme databases to general principles. J Biol Inorg Chem. 2008; 13:1205–1218.
31. Lemieux J, Goodwin PJ, Bordeleau LJ, Lauzier S, Théberge V. Quality-of-Life Measurement in Randomized Clinical Trials in Breast Cancer: An Updated Systemic Review (20012009). J Natl Cancer Inst. 2011; 103(3):178-231.
32. Sharma K, Mittal DK, Kesarwani RC, Chowdhery L. Diagnostic and prognostic significance of serum and tissue trace elements in breast malignancy. Indian J Med Sci. 1994; 48:227– 232.
33. Verkooijen HM, Fioretta G, Vlastos G, Morabia A, Schubert H, Sappino AP. Important increase of invasive lobular breast cancer incidence in Geneva, Switzerland. Int J Cancer. 2003; 104(6): 778-81.
34. American Cancer Society, Cancer Facts & Figures, Breast Carcinoma In Situ, 2015, page; 26-28.
35. Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, et al. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med. 2003. 9:1081-1084.
36. Roy SS, Mukherjee S, Mukhopadhyay S, Das SK. Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines. Mol Cancer Ther. 2004.3(2):199-204.
37. Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K, Sarangi R. Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions, an Indian study. Environ Int. 2006. 32(5):630-7.
38. Ionescu JG, Novotny J, Stejskal VD, Latsch A, Blaurock-Busch E, Eisenmann-Klein M. Increased levels of transition metals in breast cancer tissue. Neuro Endocrinol Lett. 2006. 27(Suppl 1).
39. Kilic E, Saraymen R, Demiroglu A, Ok E. Chromium and manganese levels in the scalp hair of normal and patients with breast cancer. Biol Trace Elem Res. 2004. 102(13): 19-25.
40. Geraki K, Farquharson MJ, Bradley DA. Concentrations of Fe, Cu and Zn in breast tissue, a synchrotron XRF study. Phys Med Biol. 2002. 47:2327–2339.