A possible alternate pathway for intravascular thrombosis - Investigation of the circumstantial evidence by microfluidics
Abstract
In light of the literature,
in this hypothesis, we aimed to settle up an experimental procedure and
possible mechanism for bacteremia induced disseminated intravascular
coagulation via QA. Bacteremia resulting in sepsis and disseminated
intravascular coagulation (DIC) are known for thrombosis and coagulopathy. DIC,
which results in simultaneous activation and consumption of coagulation
factors, could be investigated using microfluidics as a tool. Here, we propose
the hypothesis that bacteria (e.g. E.coli) mediated DIC results from a
collective phenomenon called “quorum acting” (QA). If our hypothesis is true,
than the coagulation cascade will be activated before systemic inflammation. To
check for QA we propose to perform a hemodynamic experiment where blood is
controllably flown over E.coli clusters in a microfluidic device.
Further, manipulation of the physical properties (flow rate mimicking condition
like venous stasis) and chemical properties (hyperglycaemia as in uncontrolled
diabetes mellitus) of blood could be done using microfluidic device to mimic
their etiopathogenesis and to validate our proposed mechanism that
quorum acting mediated DIC occurs rapidly in venous stasis and uncontrolled
diabetes mellitus respectively.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Review Article |
| Authors | |
| Publication Date | January 31, 2017 |
| Published in Issue | Year 2017 |