Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors

Tugba Gur; Gulsen Enterili; Necip Pirincci; Canan Demir; Halit Demir; Mehmet Kaba; Huseyin Eren

doi:10.17546/msd.292489

Research Article

Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors

Year 2017, , 23 - 26, 31.03.2017

Tugba Gur , Gulsen Enterili Necip Pirincci , Canan Demir Halit Demir , Mehmet Kaba , Huseyin Eren

https://doi.org/10.17546/msd.292489

Abstract

Objective:
Reactive oxygen species (ROS) and antioxidant capacity have been implicated
in the pathogenesis of various diseases, and cancers. Oxidative stress can
cause tumor angiogenesis and may be carcinogenic. However, the relationship
between antioxidant capacity and various cancers has been researched in
several clinical trials.

Materials and Methods: In this
study, we aimed to identify serum Nitric Oxide (NO), Arylesterase (ARE) and
paraoxonase (PON) activities in patients with renal tumors. Serum ARE, PON and
NO levels were measured by spectrophotometer.

Results:
Increased
activity of serum nitric oxide (NO) was determined in cancer group. Serum
Arylesterase (ARE) were significantly lower in the patient group than the
control group. Increased activity of Serum paraoxonase (PON) were detected in
the control group (p < 0.05).

Conclusion: Our
results indicates that Nitric oxide (NO), arylesterase (ARE) and paraoxonase
(PON) activities may play an important role in the pathogenesis of renal cell
cancer.

Keywords

ARE, NO, PON, Arylesterase, Nitric Oxide, Serum paraoxonase, Renal tumor

References

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2. Chow WH, Devesa SS, and Warren JL et al., JAMA, 281,1628–31(1999).
3. Dhote R, Pellicer-Coeuret M, Thiounn N, et al., BJU Int.86: 20–7 (2000).
4. McLaughlin JK, Blot WJ, Devesa SS et al., Renal cancer. In: Schottenfeld D and Fraumeni JF (eds) Cancer Epidemiology and Prevention. New York, NY: Oxford University Press, pp. 1142–55 (1996).
5. Templar J, Kon SP, Milligan TP, et al., Nephrology Dialysis Transplantation 14, 946–51(1999).
6. Batcioglu K, Mehmet N, Ozturk IC, et al., Cancer Invest. 24, 18–21(2006).
7. Nishikawa M, Cancer Lett, 266, 53–9 (2008).
8. Ray G, Batra S, Shukla NK et al., Breast Cancer Res Treat.59:163–70 (2000).
9. Wang GQ, Dawsey SM, and Li Y, Cancer Epidemiology, Biomarkers and Prevention, 3,161–66 (1994).
10. Oberley LW, and Buettner GR, Cancer Research 39: 1141–9 (1979).
11. Gecit I, Aslan M, Gunes M, et al., J Cancer Res, Clin, Oncol., 138: 739–43 (2012).
12. Cortas NK, and Wakid NW. Clin. Chem., 36, 1440-1443 (1990).
13. Erel O. Clin. Biochem, 37, 112–229 (2004).
14. Erel O, Clin. Biochem, 38, 1103–1111 (2005).
15. Gülçin I, Oktay M, Küfrevioǧlu, ÖI, and Aslan A, Journal of Ethnopharmacology, 79 (3), 325-329 (2002).
16. Jaruga P, Zastawny TH, Skokowski J, et al., FEBS Lett. 341(1),59-64 (1994).
17. Sun Y, and Oberley LW, Free Radical Free Radic, Biol, Med. 21: 335–48 (1996).
18. Blackburn RV, Spitz DR, Liu X, et al., Free Radic Biol, Med, 26, 419–30 (1999). 9) Toyokuni S, Okamoto K, Yodoi J, et al., FEBS Lett.16, 3581–3 (1995).
19. Meyer TE, Liang HQ, Buckley AR, et al., International Journal of Cancer 3: 55–63 (1998).
20. Mantovani G, MaccioA, Madeddu C, et al., International Journal of Cancer 98: 84–91 (2002).
21. Szatrowski TP, and Nathan CF, Cancer Res. 51, 794–8 (1991).
22. Marnett LJ, Mutat Res 424, 83–95 (1999).
23. Seven A, Civelek S, Inci E, et al., Clinical Biochemistry, 32, 369–73 (1999).
24. Marnett LJ, Carcinogenesis. 21, 361–370 (2000).
25. Vo TKO, Druez C, Delzenne N, et al., Carcinogenesis. 9(11), 2009–2013 (1988).
26. Corrocher R, Casaril M, Bellisola G, et al., Cancer, 58(8), 1658–62 (1986).
27. Nakada T, Akiya T, Koike H et al., Eur Urol, 14(1), 50–5 (1988).
28. Ozturk HS, Karaayvaz M, Kacmaz M, et al., Cancer Biochemistry Biophysics, 16, 157–168 (1998).
29. Ferraris AM, Rolfo M, Mangerini R, et al., Am J Hematol., 47, 237–278 (1994).
30. Farber CM, Kanganis DN, Liebes LF, et al., Br J Haematol 72, 32–35 (1989).

Year 2017, , 23 - 26, 31.03.2017

Tugba Gur , Gulsen Enterili Necip Pirincci , Canan Demir Halit Demir , Mehmet Kaba , Huseyin Eren

https://doi.org/10.17546/msd.292489

Abstract

References

1. Curti BD, Renal cell carcinoma. JAMA,. 292, 97–100 (2004).
2. Chow WH, Devesa SS, and Warren JL et al., JAMA, 281,1628–31(1999).
3. Dhote R, Pellicer-Coeuret M, Thiounn N, et al., BJU Int.86: 20–7 (2000).
4. McLaughlin JK, Blot WJ, Devesa SS et al., Renal cancer. In: Schottenfeld D and Fraumeni JF (eds) Cancer Epidemiology and Prevention. New York, NY: Oxford University Press, pp. 1142–55 (1996).
5. Templar J, Kon SP, Milligan TP, et al., Nephrology Dialysis Transplantation 14, 946–51(1999).
6. Batcioglu K, Mehmet N, Ozturk IC, et al., Cancer Invest. 24, 18–21(2006).
7. Nishikawa M, Cancer Lett, 266, 53–9 (2008).
8. Ray G, Batra S, Shukla NK et al., Breast Cancer Res Treat.59:163–70 (2000).
9. Wang GQ, Dawsey SM, and Li Y, Cancer Epidemiology, Biomarkers and Prevention, 3,161–66 (1994).
10. Oberley LW, and Buettner GR, Cancer Research 39: 1141–9 (1979).
11. Gecit I, Aslan M, Gunes M, et al., J Cancer Res, Clin, Oncol., 138: 739–43 (2012).
12. Cortas NK, and Wakid NW. Clin. Chem., 36, 1440-1443 (1990).
13. Erel O. Clin. Biochem, 37, 112–229 (2004).
14. Erel O, Clin. Biochem, 38, 1103–1111 (2005).
15. Gülçin I, Oktay M, Küfrevioǧlu, ÖI, and Aslan A, Journal of Ethnopharmacology, 79 (3), 325-329 (2002).
16. Jaruga P, Zastawny TH, Skokowski J, et al., FEBS Lett. 341(1),59-64 (1994).
17. Sun Y, and Oberley LW, Free Radical Free Radic, Biol, Med. 21: 335–48 (1996).
18. Blackburn RV, Spitz DR, Liu X, et al., Free Radic Biol, Med, 26, 419–30 (1999). 9) Toyokuni S, Okamoto K, Yodoi J, et al., FEBS Lett.16, 3581–3 (1995).
19. Meyer TE, Liang HQ, Buckley AR, et al., International Journal of Cancer 3: 55–63 (1998).
20. Mantovani G, MaccioA, Madeddu C, et al., International Journal of Cancer 98: 84–91 (2002).
21. Szatrowski TP, and Nathan CF, Cancer Res. 51, 794–8 (1991).
22. Marnett LJ, Mutat Res 424, 83–95 (1999).
23. Seven A, Civelek S, Inci E, et al., Clinical Biochemistry, 32, 369–73 (1999).
24. Marnett LJ, Carcinogenesis. 21, 361–370 (2000).
25. Vo TKO, Druez C, Delzenne N, et al., Carcinogenesis. 9(11), 2009–2013 (1988).
26. Corrocher R, Casaril M, Bellisola G, et al., Cancer, 58(8), 1658–62 (1986).
27. Nakada T, Akiya T, Koike H et al., Eur Urol, 14(1), 50–5 (1988).
28. Ozturk HS, Karaayvaz M, Kacmaz M, et al., Cancer Biochemistry Biophysics, 16, 157–168 (1998).
29. Ferraris AM, Rolfo M, Mangerini R, et al., Am J Hematol., 47, 237–278 (1994).
30. Farber CM, Kanganis DN, Liebes LF, et al., Br J Haematol 72, 32–35 (1989).

There are 30 citations in total.

Details

Subjects	Health Care Administration
Journal Section	Research Article
Authors	Tugba Gur Gulsen Enterili This is me Necip Pirincci Canan Demir This is me Halit Demir Mehmet Kaba Huseyin Eren This is me
Publication Date	March 31, 2017
Published in Issue	Year 2017

Cite

APA	Gur, T., Enterili, G., Pirincci, N., Demir, C., et al. (2017). Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors. Medical Science and Discovery, 4(3), 23-26. https://doi.org/10.17546/msd.292489
AMA	Gur T, Enterili G, Pirincci N, Demir C, Demir H, Kaba M, Eren H. Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors. Med Sci Discov. March 2017;4(3):23-26. doi:10.17546/msd.292489
Chicago	Gur, Tugba, Gulsen Enterili, Necip Pirincci, Canan Demir, Halit Demir, Mehmet Kaba, and Huseyin Eren. “Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors”. Medical Science and Discovery 4, no. 3 (March 2017): 23-26. https://doi.org/10.17546/msd.292489.
EndNote	Gur T, Enterili G, Pirincci N, Demir C, Demir H, Kaba M, Eren H (March 1, 2017) Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors. Medical Science and Discovery 4 3 23–26.
IEEE	T. Gur, G. Enterili, N. Pirincci, C. Demir, H. Demir, M. Kaba, and H. Eren, “Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors”, Med Sci Discov, vol. 4, no. 3, pp. 23–26, 2017, doi: 10.17546/msd.292489.
ISNAD	Gur, Tugba et al. “Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors”. Medical Science and Discovery 4/3 (March 2017), 23-26. https://doi.org/10.17546/msd.292489.
JAMA	Gur T, Enterili G, Pirincci N, Demir C, Demir H, Kaba M, Eren H. Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors. Med Sci Discov. 2017;4:23–26.
MLA	Gur, Tugba et al. “Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors”. Medical Science and Discovery, vol. 4, no. 3, 2017, pp. 23-26, doi:10.17546/msd.292489.
Vancouver	Gur T, Enterili G, Pirincci N, Demir C, Demir H, Kaba M, Eren H. Investigation of Serum Enzyme Activity of Nitric Oxide (NO), Arylesterase (ARE) and Paraoxanase (PON) in Renal Tumors. Med Sci Discov. 2017;4(3):23-6.