Recurrent ovary cancer presenting with scleroderma - A rare case report

Abstract

Scleroderma is a chronic autoimmune multisystem disorder which is characterized by progressive fibrosis of the skin and internal organs. Ovary cancers with scleroderma have been reported in the literature. But recurrent ovary cancer with scleroderma has not been reported before.

Here, we report a 65 -year old female patient presenting with recurrent ovary cancer and subsequently diagnosed with scleroderma. Due to literature sources, this is the first case of presenting with recurrent ovary cancer and scleroderma

Keywords

• recurrent,ovary cancer,scleroderma

References

1. 1. Kotnur MR , Suresh P , Reddy VS , Sharma T , Salim NA .Systemic Sclerosis with Multiple Pulmonary Manifestations. J Clin Diagn Res [Internet]. 2016 June ;10(6):OD16-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4963699.
2. 2. Marek M, Rudny R .Scleroderma of geriatric age and scleroderma-like paraneoplastic syndrome - description of two cases. Reumatologia [Internet]. 2016 June;54(2):91-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 4918051.
3. 3. Lachner KD. Caring for the Patient With Limited Systemic Scleroderma. Orthop Nurs. [Internet].2016 Jan-Feb;35(1):5-10; quiz 11-2.Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 26814000.
4. 4. Scheinfeld N. A review of the cutaneous paraneoplastic associations and metastatic presentations of ovarian carcinoma. Clin Exp Dermatol. [Internet]. 2008 Jan ;33(1):10-5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 17983453.
5. 5. Cannavó SP, Borgia F, Adamo B, Guarneri B. J .Simultaneous development and parallel course of disseminated superficial porokeratosis and ovarian cancer: Coincidental association or true paraneoplastic syndrome? Am Acad Dermatol. [Internet]. 2008 Apr;58(4):657-60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 18258333.
6. 6. Kishikawa T, Miyashita T, Fujiwara E, Shimomura O, Yasuhi I, Niino D, et al .Multicentric reticulohistiocytosis associated with ovarian cancer. Mod Rheumatol. [Internet].2007;17(5):422-5.Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 17929137.
7. 7. Stashower ME, Rennie TA, Turiansky GW, Gilliland WR. Ovarian cancer presenting as leukocytoclastic vasculitis. J Am Acad Dermatol. [Internet].1999 Feb ;40(2 Pt 2):287-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 10025849.
8. 8. Jedlickova H, Durčanská V, Vašků V. Paraneoplastic Scleroderma: Are There Any Clues? Acta Dermatovenerol Croat. [Internet]. 2016 Apr ;24(1):78-80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 27149136.

9. 9. Kyndt X , Hebbar M, Queyrel V, Hachulla E, Hatron PY, Devulder B. Systemic scleroderma and cancer. Search for predictive factors of cancer in 123 patients with scleroderma. Rev Med Interne. [Internet]. 1997 Jul;18(7):528-32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 9255370.
10. 10. Bielefeld P , Meyer P, Caillot D, Dalac S, Camus P, Tavernier C, et al. Systemic scleroderma and cancers: 21 cases and review of the literature. Rev Med .[Internet]. 1996 Jan;17(10):810-3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 8976973.
11. 11. Kawakami Y, Nakamura K, Nakamura-Wakatsuki T, Ohtsuka M, Oyama N, Kaneko F. Systemic sclerosis complicated by ovarian cancer. J Dermatol. [Internet]. 2007 Oct;34(10):720-3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 17908147.
12. 12. Vottery R, Biswas G, Deshmukh C, Gupta S, Nair R, Parikh P. Scleroderma and dermographism in a case of carcinoma ovary. Indian J Dermatol Venereol Leprol. [Internet].2005 Nov ;71(6):429-30. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 16394490.
13. 13. Eisenbeilss C, Weizel J, Wolff H. Scleroderma-like skin changes following administration of paclitaxel for the treatment of ovarian carcinoma. J Dtsch Dermatol Ges. [Internet]. 2003 Jun;1(6):468-70. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 16295141.
14. 14. De Angelis R , Bugatti L, Cerioni A, Del Medico P, Filosa G. Diffuse scleroderma occurring after the use of paclitaxel for ovarian cancer. [Internet] Clin Rheumatol. 2003 Feb;22(1):49-52. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 12605319.
15. 15. Young R, Towbin B, Isern R. Scleroderma and ovarian carcinoma. Br J Rheumatol. [Internet].1990 Aug;29(4):314. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 2379051.
16. 16. Konishi Y , Sato H, Sato N, Fujimoto T, Fukuda J, Tanaka T.Scleroderma- like cutaneous lesions induced by paclitaxel and carboplatin for ovarian carcinoma, not a single course of carboplatin, but re induced and worsened by previously administrated paclitaxel. J Obstet Gynaecol Res. [Internet]. 2010 Jun;36(3):693-6. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 20598060.
17. 17. Su F , Cummings KW, Krigman H, Ranganathan P.Meigs' syndrome: a rare cause of recurrent pleural effusion in scleroderma. Rheumatol Int. [Internet].2013 Oct ;33(10):2647-51. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 22538500.
18. 18. Reynolds TD , Knights SE. Recurrent metastatic breast cancer presenting with paraneoplastic scleroderma. [Internet]. BMJ Case Rep. 2014 Mar 11;2014. Available from: http : // www . ncbi . nlm .nih.gov/pubmed/ 24618872.