Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p

Year 2018, , 188 - 191, 30.05.2018

Tarik Onur Tiryaki , Sezen Genc Gulcin Bagatir Ozan Kivanc Cefle , Sukru Palanduz , Gulcin Yegen Oner Dogan , Meliha Nalcaci

https://doi.org/10.17546/msd.413622

Abstract

Chronic
lymphocytic Leukemia (CLL) is the most common form of leukemia in adults.
Clinical findings may broad range vary. Detecting some deletions using the FISH
method may help us to foresee the progression of the disease and to choose a
better treatment method in healing the patient. In this case report, we will
present you a CLL patient with t(7;14), t(14;19) and  17p deletions, which are known for bad
prognosis, developing autoimmune hemolytic anemia which is refractor to the
treatment. This patient unfortunately died due to a clinical form of
hemophagocytic syndrome including prolymphocytic transformation.  

Keywords

Chronic Lymphocytic Leukemia, Hemophagocytic Syndrome, hematologic malignancies, t(7;14), t(14;19), 17p, deletion

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