T-cell Non-Hodgkin lymphoma associated with myelodysplasia: A case report in a child

Year 2018, , 202 - 206, 30.05.2018

Gokce Pinar Reis , Aysenur Bahadir , Erol Erduran

https://doi.org/10.17546/msd.421622

Abstract

Myelodysplastic syndrome (MDS) is a clonal bone marrow
disease characterized by ineffective erythropoiesis. MDS patients have cytopenia. The risk of
acute leukemia, and particularly of acute myeloblastic leukemia (AML), is the
most important characteristic of the disease.

Myelodysplasia associated with NHL has been rarely
described in the literature. This is suggested to be due to the defect in the
immune system, an up-regulation of some cytokines, and a common molecular
origin.

In this case report article, we reported a 7-year-old
pediatric NHL case with a normal karyotype and myelodysplasia in the bone
marrow and discussed the pathogenesis of the association of NHL and
myelodysplasia.

Keywords

Lymphoma, myelodysplasia, Association

References

• 1. Steensma DP, Tefferi A. The myelodysplastic syndrome (s) : a perspective and review highligh-ting current controversies. Leuk Res. 2003; 27 : 95-120
• 2. Elghetany MT.Myelodysplastic syndromes in children: a critical review of issues in the diagnosis and classification of 887 cases from 13 published series. Arch Pathol Lab Med. 2007;131:1110-6
• 3. Link MP and Weinstein HJ: Malignant No-Hodgkin Lymphomas in children.In:Pizzo PA, Poplark DG, eds. Principles and Practive of Pediatric Oncology.Fifth Edition, Lippincott Williams and Wilkins, Philedelphia, 2006, pp:722-747
• 4. Percy CL, Smith MA, Linet M, et al. Lymphomas and reticuloendothelial neoplasms. In: Ries LAG, Smith MA, Gurney JG, et al., eds. Canser indicence and survival amon children and adolescents. United States SEER Program 1975-1995. Bethesda, MD: National Cancer Institute, SEER Program. NIH Pub. No. 99-4649, 1999:35-49.
• 5. Uematsu M, Ochi H, Ueda Y, et al: Coexistent myelodysplastic syndrome and Non-Hodgkin’s lymphoma. Report of a case and review of the literature. Int J Hematol 1995;62:45-51.
• 6. Weimar IS, Bourhis JH, De Gast GC, et al: Clonality in myelodysplastic syndrome. Leuk Lymphoma 1994;13:215-221.
• 7. Brezinova J, Zemanova Z, Randsdorfova S, et al: Prognostic significance of del(20q) in patients with hematological malignancies. Cancer Genet Cytogenet 2005;160:188-192.
• 8. Bynoe AG, Scott CS, Ford P, et al: Decreased T helper cells in the myelodysplastic syndromes. Br J Haematol 1983;54:97-102.
• 9. Colombat PH, Renoux M,Lamagnere JO, et al: Immunologic indices in myelodysplastic syndromes. Cancer 1988;61:1075-1081.
• 10. Shimamoto T, Hayashi S, Ando K, et al: Anaplastic large-cell lymphoma which showed severe inflammatory status and myelodysplasia with increased VEGF and IL-6 serum levels after long-term immunosuppressive therapy. Am J Hematol 2001;66:49-52
• 11. Fong GH, Rossant J, Gertsenstein M, et al: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66-70.
• 12. Abruzzese E, Buss D, Rainer R, et al: Progression of a myelodysplastic syndrome to pre-B lymphoblastic leukemia. A case report and cell lineage study. Ann Hematol 1996;73:35-38.
• 13. Copplestone JA, Mufti GJ, Hamblin TJ, et al: Immunologic abnormalities in myelodysplastic syndromes II. Coexistent lymphoid or plasma cell neoplasms. A report of 20 cases unrelated to chemotherapy. Br J Haematol 1986;63:149-159.
• 14. Florensa L, Vallespi T, Woessner S, et al: Incidence and characteristics of lymphoid malignancies in untreated myelodysplastic syndromes. Leuk Lymphoma 1996;23:609-612.
• 15. Hamblin TJ: Immunologic abnormalities in myelodysplastic syndromes. Semin Hematol 1996;3:150-162.
• 16. Anzai T, Hirose W, Nakane H, et al: Myelodysplastic syndrome associated with immunoblastic lymphadenopathy-like T-cell lymphoma: simultaneous clinical improvement with chemotherapy. Jpn J Clin Oncol 1994;24:106-110.
• 17. Takaku T, Miyazawa K, Sashida G, et al: Hepatosplenic αβ T- cell lymphoma with myelodysplastic syndrome. Int J Hematol 2005;82:143-147.
• 18. Xu B, Meng FY, Li YQ T- cell non-Hodgkin lymphoma with myelodysplastic syndrome: A case report. Zhonghua Zhong Liu Za Zhi 2005;27:320.
• 19. Sato T, Shiga Y, Takeda H, et al: IBL-like T-cell lymphoma with helper T-cell phenotype in a case of myelodysplastic syndrome. Rinsho Ketsueki 1986;27:612-616.
• 20. Auger MJ, Nash JRG, Mackie MJ, et al: Marrow involvement with T cell lymphoma initially presenting as abnormal myelopoiesis. J Clin Pathol 1986;39:134-137.
• 21. Kawashima K, Furukawa Y, Akutu M, et al: Primary non- Hodgkin’s lymphoma, small lymphocytic type, in the spleen complicating myelodysplastic syndrome. J Jpn Soc Intern Med 1988;77:1051-1055.
• 22. Breccia M, Petti MC, D’Elia GM, et al: Cutaneous pleomorphic T-cell lymphoma coexisting with myelodysplastic syndrome transforming into acute myeloid leukemia: Successful treatment with a fludarabine-containing regimen. Eur J Haematol 2002;68:1-3.
• 23. Dalamaga M, Karmaniolas K, Chavelas C, et al: Coexistence of primary refractory anemia with ringed sideroblasts and T-cell lymphoblastic non- Hodgkin lymphoma. Acta Haematol 2004;111:171-172.
• 24. Cheng HB, Luo MZ, Zhang SM: A case of acute myelomonocytic leukemia transformed from myelodysplastic syndrome coincident with malignant lymphoma. Mod Diagn Treat 2004;15:191.
• 25. Liu GX, Li X: Coexistence of myelodysplastic syndrome and malignant lymphoma in the peritoneal cavity: a case report. Henan Zhong Liu Xue Za Zhi 2001;14:172.
• 26. Rostoker G, Raphael M, Boisnick S, et al: Coexistence of Sezary syndrome and dysmyelopoiesis with an excess of myeloblasts. J Am Acad Dermatol 1986;15:1296-1298.
• 27. Kazakov DV, Mentzel T, Burg G, et al: Blastic natural killer-cell lymphoma of the skin associated with myelodysplastic syndrome or myelogenous leukaemia: A coincidence or more? Br J Dermatol 2003;149:869-876.
• 28. Mori A, Hashino S, Imamura M, et al: Bone marrow dysplasia with basophilic cells in a patient with angiocentric lymphoma. Acta Haematol.1998;99(2):98-101.
• 29. Huang HH, Zhu JY, Han JY, et al: Co-existent de novo myelodysplastic syndrome and T-cell non- Hodgkin lymphoma: a common origin or not? J Int Med Res. 2009 Jan-Feb;37(1):270-6