Family history in chronic psychotic disorders

Year 2019, , 8 - 11, 28.02.2019

Şengül Şahin , Gülçin Elboğa

https://doi.org/10.17546/msd.493056

Abstract

Objective: Psychosis is a set of symptoms that consist of delusions, hallucinations
an thought disorders. In DSM 5, psychoses were collected under the title of
schizophrenia spectrum and other psychotic disorders. The aim of this study was
to investigate the prevalence of a family history of psychiatric disorders in
patients with chronic psychosis and to examine the groups of these psychiatric
disorders.

Material and Methods: A total
of 282 patients with chronic psychosis, defined by DSM- 5diagnostic criteria,
were included in this study. Sociodemographic parameters and family history of
chronic psychosis patients were retrospectively reviewed.

Results: The mean
age of the patients was 41.3 years, the mean age of onset of the disease was
22.8 years and the mean number of hospitalizations was 5.78 years. Patient
group consisted of 94 (33.3%) males and 188 (66.7%) females. 48.6% (137/282) of
patients with chronic psychosis had a history of psychiatric disorder in their
first-degree relatives. In the diagnostic groups, there were 1.8% (5/282)
schizoaffective disorder, 18.4% (52/282) schizophrenia, 6% (17/282) bipolar
disorder, 5.7% (16/232) major depression, 13% , 8 (39/282) unspecified
schizophrenia spectrum and other psychotic disorder, 2.5% (7/282) mental
retardation, 0.4% (1/232) obsessive-compulsive disorder family history.

Conclusion: This study provides
a platform for future studies to contribute to the development of early
intervention and prevention approaches in populations at risk for further
clarification of the role of family history in individuals with a family history

Keywords

psychosis, schizophrenia

References

• 1. Gaebel W, Focus on psychosi Focus on Psychosis. Dialogues Clin Neurosci. 2015; 17(1): 9–18.
• 2. Tan N, Van Os J. The schizophrenia spectrum and other psychotic disorders in the DSM-5. Tijdschr Psychiatr. 2014;56(3):167-72.
• 3. Cardno AG, Owen MJ . Genetic Relationships Between Schizophrenia, Bipolar Disorder, and Schizoaffective Disorder. Schizophr Bull. 2014;40(3):504-515.doi: 10.1093/schbul/sbu016
• 4. Käkelä J, Panula J, Oinas E, Hirvonen N, Jääskeläinen E, Miettunen J. Family history of psychosis and social, occupational and global outcome in schizophrenia: a meta-analysis. Acta Psychiatr Scand. 2014;130(4):269-78.
• 5. Andreasen NC, Endicott J, Spitzer RL, Winokur G. The Family History Method Using Diagnostic Criteria Reliability and Validity. Arch Gen Psychiatry. 1977;34(10):1229-1235. doi:10.1001/archpsyc.1977.01770220111013
• 6. Tandon R1, Gaebel W, Barch DM, Bustillo J, Gur RE, Heckers S, Malaspina D, Owen MJ, Schultz S, Tsuang M, Van Os J, Carpenter W..Definition and description of schizophrenia in the DSM-5. Schizophr Res. 2013 Oct;150(1):3-10. doi: 10.1016/j.schres.2013.05.028.
• 7. Ivleva E, Thaker G, Tamminga CA. Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder. Schizophr Bull. 2008; 34(4):734-42.
• 8. Kendler KS, Gardner CO. The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies. PsycholMed. 1997; 27(2):411-9.
• 9. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.Lancet. 2009; 17; 373(9659):234-9.
• 10. CosgroveVE, Suppes T. Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia.BMC Med. 2013; 14; 11():127.
• 11. Blackwood DH, Fordyce A, Walker MT, StClair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.Am J Hum Genet. 2001; 69(2):428-33.