Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy

Şeyda Belli; Halit Demir; Ayşegül Kırankaya

doi:10.17546/msd.547201

Research Article

Year 2019, , 84 - 87, 30.04.2019

Şeyda Belli , Halit Demir , Ayşegül Kırankaya

https://doi.org/10.17546/msd.547201

Abstract

References

1. Malik UU, Siddiqui IA, Hashim Z, Zarina S. Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma. Clin Chim Acta. 2014 Mar 20;430:38-42. Doi: 10.1016/j.cca.2013.12.033
2. Özkaya Toraman K, Altun M. Oral Kavite Kanseri Tedavisine Güncel Bakış. Ünür M, editör. Ağız Kanserlerinin Tanı, Tedavi ve Prognozu. 1. Baskı. Ankara: Türkiye Klinikleri; 2019. p.24-33.
3. Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis. J Cancer Res Clin Oncol. 2015 Oct;141(10):1757-66. Doi: 10.1007/s00432-015-1941-2
4. Prabhu K, Bhat GP. Serum total glutathione-s-transferase levels in oral cancer. J Cancer Res Ther. 2007 Jul-Sep;3(3):167-8. PMID: 18079581
5. Fu TY, Hou YY, Chu ST, Liu CF, Huang CH, Chen HC, Hsiao M, Lu PJ, Wang JS, Ger LP. Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas. Head Neck. 2011 Nov;33(11):1606-15. doi: 10.1002/hed.21653. PMID:21990225
6. Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D.Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer. Otolaryngol Pol. 2016 Nov 20;70(6):20-25. doi: 10.5604/01.3001.0009.3735. PMID: 28485283
7. Lee JR, Roh JL, Lee SM, Park Y, Cho KJ, Choi SH, Nam SY, Kim SY. Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2017 Nov;143(11):2257-2265. doi: 10.1007/s00432-017-2466-7. Epub 2017 Jun 26. PMID: 28653098
8. Gurudath S, Ganapathy K, D S, Pai A, Ballal S, Ml A. Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer--a comparative study. Asian Pac J Cancer Prev. 2012;13(9):4409-12. Doi: 10.7314/APJCP.2012.13.9.4409 PMID: 23167351
9. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 2006 Sep;10(3):241-52 DOI: 10.1016/j.ccr.2006.08.009. PMID: 16959615
10. Banerjee S, Mukherjee S, Mitra S, Singhal P. Altered expression of mitochondrial antioxidants in oral squamous cell carcinoma. J Oral Sci. 2017;59(3):439-446. doi: 10.2334/josnusd.16-0655.
11. Fu TY, Tsai MH, Wang JS, Ger LP. Antioxidant enzymes in oral verrucous carcinoma. J Oral Pathol Med. 2017 Jan;46(1):46-49. doi: 10.1111/jop.12460. Epub 2016 Jun 1.PMID: 27245640
12. Balasenthil S, Saroja M, Ramachandran CR, Nagini S.Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis. Br J Oral Maxillofac Surg. 2000 Aug;38(4):267-70. PMID: 10922148
13. Sabitha KE, Shyamaladevi CS. Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy. Oral Oncol. 1999 May;35(3):273-7. PMID: 10621847

Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy

Year 2019, , 84 - 87, 30.04.2019

Şeyda Belli , Halit Demir , Ayşegül Kırankaya

https://doi.org/10.17546/msd.547201

Abstract

Objective:
In this study, we investigated the glutathione peroxidase enzyme activity
changes in patients with oral cavity malignancies.

Material
and Methods: Twenty-five patients with oral cavity malignancy and
24 healthy individuals were included in the study. There was no statistically significant difference between the groups in terms of age, gender and smoking-alcohol consumption habits.

Results:
Glutathione peroxidase activity was found to be significantly lower in the
blood of patients with oral cavity malignancies than the control group (
2,238±0,039, p: 0,0001).

Conclusion:
The level of glutathione peroxidase in the blood can be used as an important
biomarker for the prognosis and to guide to the treatment approaches for the
patients with oral cavity malignancy.

Keywords

Oral cavity malignancy, glutathione peroxidase

References

1. Malik UU, Siddiqui IA, Hashim Z, Zarina S. Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma. Clin Chim Acta. 2014 Mar 20;430:38-42. Doi: 10.1016/j.cca.2013.12.033
2. Özkaya Toraman K, Altun M. Oral Kavite Kanseri Tedavisine Güncel Bakış. Ünür M, editör. Ağız Kanserlerinin Tanı, Tedavi ve Prognozu. 1. Baskı. Ankara: Türkiye Klinikleri; 2019. p.24-33.
3. Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis. J Cancer Res Clin Oncol. 2015 Oct;141(10):1757-66. Doi: 10.1007/s00432-015-1941-2
4. Prabhu K, Bhat GP. Serum total glutathione-s-transferase levels in oral cancer. J Cancer Res Ther. 2007 Jul-Sep;3(3):167-8. PMID: 18079581
5. Fu TY, Hou YY, Chu ST, Liu CF, Huang CH, Chen HC, Hsiao M, Lu PJ, Wang JS, Ger LP. Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas. Head Neck. 2011 Nov;33(11):1606-15. doi: 10.1002/hed.21653. PMID:21990225
6. Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D.Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer. Otolaryngol Pol. 2016 Nov 20;70(6):20-25. doi: 10.5604/01.3001.0009.3735. PMID: 28485283
7. Lee JR, Roh JL, Lee SM, Park Y, Cho KJ, Choi SH, Nam SY, Kim SY. Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2017 Nov;143(11):2257-2265. doi: 10.1007/s00432-017-2466-7. Epub 2017 Jun 26. PMID: 28653098
8. Gurudath S, Ganapathy K, D S, Pai A, Ballal S, Ml A. Estimation of superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia and oral cancer--a comparative study. Asian Pac J Cancer Prev. 2012;13(9):4409-12. Doi: 10.7314/APJCP.2012.13.9.4409 PMID: 23167351
9. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 2006 Sep;10(3):241-52 DOI: 10.1016/j.ccr.2006.08.009. PMID: 16959615
10. Banerjee S, Mukherjee S, Mitra S, Singhal P. Altered expression of mitochondrial antioxidants in oral squamous cell carcinoma. J Oral Sci. 2017;59(3):439-446. doi: 10.2334/josnusd.16-0655.
11. Fu TY, Tsai MH, Wang JS, Ger LP. Antioxidant enzymes in oral verrucous carcinoma. J Oral Pathol Med. 2017 Jan;46(1):46-49. doi: 10.1111/jop.12460. Epub 2016 Jun 1.PMID: 27245640
12. Balasenthil S, Saroja M, Ramachandran CR, Nagini S.Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis. Br J Oral Maxillofac Surg. 2000 Aug;38(4):267-70. PMID: 10922148
13. Sabitha KE, Shyamaladevi CS. Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy. Oral Oncol. 1999 May;35(3):273-7. PMID: 10621847

There are 13 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Research Article
Authors	Şeyda Belli Halit Demir 0000-0001-5598-2601 Ayşegül Kırankaya This is me 0000-0002-0411-3999
Publication Date	April 30, 2019
Published in Issue	Year 2019

Cite

APA	Belli, Ş., Demir, H., & Kırankaya, A. (2019). Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Medical Science and Discovery, 6(4), 84-87. https://doi.org/10.17546/msd.547201
AMA	Belli Ş, Demir H, Kırankaya A. Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Med Sci Discov. April 2019;6(4):84-87. doi:10.17546/msd.547201
Chicago	Belli, Şeyda, Halit Demir, and Ayşegül Kırankaya. “Comparison of Serum Glutathione Peroxidase Levels in Healthy Controls and Patients With Oral Cavity Malignancy”. Medical Science and Discovery 6, no. 4 (April 2019): 84-87. https://doi.org/10.17546/msd.547201.
EndNote	Belli Ş, Demir H, Kırankaya A (April 1, 2019) Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Medical Science and Discovery 6 4 84–87.
IEEE	Ş. Belli, H. Demir, and A. Kırankaya, “Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy”, Med Sci Discov, vol. 6, no. 4, pp. 84–87, 2019, doi: 10.17546/msd.547201.
ISNAD	Belli, Şeyda et al. “Comparison of Serum Glutathione Peroxidase Levels in Healthy Controls and Patients With Oral Cavity Malignancy”. Medical Science and Discovery 6/4 (April 2019), 84-87. https://doi.org/10.17546/msd.547201.
JAMA	Belli Ş, Demir H, Kırankaya A. Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Med Sci Discov. 2019;6:84–87.
MLA	Belli, Şeyda et al. “Comparison of Serum Glutathione Peroxidase Levels in Healthy Controls and Patients With Oral Cavity Malignancy”. Medical Science and Discovery, vol. 6, no. 4, 2019, pp. 84-87, doi:10.17546/msd.547201.
Vancouver	Belli Ş, Demir H, Kırankaya A. Comparison of serum glutathione peroxidase levels in healthy controls and patients with oral cavity malignancy. Med Sci Discov. 2019;6(4):84-7.