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Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome

Year 2017, Volume: 4 Issue: 2, 18 - 22, 28.02.2017
https://doi.org/10.17546/msd.292428

Abstract




















Bartter syndrome
 and Gitelman syndrome  are rare autosomal recessive syndromes. In
extremely rare cases, GS may diagnosed with growth retardation and diabetes
mellitus. In this 3-case series, growth retardation was identified at 17-year
follow-up of our dizygotic twin patients diagnosed with BS and
glucose metabolism disorder was developed.  Whereas, 3RD.
patient diagnosed with GS in adulthood period developed diabetes mellitus after
8 years follow up. Chronic hypopotassemia has been shown to cause diabetes
mellitus and growth retardation ın several articles. Potassium plays an
important role in insulin, IGF-1 and growth hormone cycle. Herein, we aimed to
draw attention to that, the presence of chronic hypopotassemia may precipitate
to diseases such as growth retardation and diabetes mellitus over time.

References

  • 4) Bettinelli A, Bianchetti MG, Girardin E, et al. Use of calcıum excretion values tı distinguish two forms of primary renal tubuler hypokalemic alkalosis: Bartter and Gitelman syndromes. J Pediatr 1992; 120:38.
  • 5) Cruz DN, Shaer AJ, Bia MJ, et al. Gitelman’s syndrome revisited: an evaluation of symptoms and health related quality of life. Kıdney Int 2001;59:710.
  • 6) Cruz DN, Simon DB, Nelson-Williams C, et al. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 2001; 37:1458.
  • 8) Sann L, David L, Bernheim J, François R. Hypophosphatemia and hyperparathyroidism in a case of Bartter’s syndrome. Helv Pediatr Acta 1978; 33:299
  • 9) Bettinelli A, Vigano C, Provero MC, et al. Phosphate homeostasis in Bartter syndrome: a case-control study. Pediatr Nephrol 2014; 29:2133.
  • 10) Riveira-Munoz E, Chang Q, Godefroid N, et al. Transcriptional and functional analyses of SLC12A3 mutations: new ckues for the pathogenesis of Gitelman syndrome. J Am Soc Nephrol 2007; 18:1271.
  • 1) Flyvbjerg A, Dorup I, Everts ME, Orskow H. Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone ad insulin like growth factor I. Metabolism 1991;40:769-75.
  • 2) Gil-Pena H, Garcia-Lopez E, Alvares-Garcia O, Loredo V, Carbajo-Perez E, Ordonez FA, et al. Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth hormone treatment. Am J Physiol Renal Phsiol 2009;297:F639-45.
  • 3) Ruvalcaba RH, Martinez FE. Case report: familial growth hormone deficiency associated with Bartter’s syndrome. Am J Med Sci 1992;303:411-4.
  • 4) Buyukcelik M, Keskin M, Kilic BD, Kor Y, Balat A, Bartter syndrome and growth hormone deficiency: three cases. Pediatr Nephrol 2012;27:2145-8.
  • 6) Hong R, Ling Q, WeiMing W, Jun M, Wen Z, Ping YS, Hao S, Xiao L, Nan C. Abnormal Glucose Metabolism and Insulin Sensivity in Chinese Patients with Gitelman Syndrome. Am J Nephrol 2013;37:152-157.
  • 7) Xu S, Kim JH, Hwang KH, Das R, Quan X, Nguyen TT, Kim SJ, Cha SK, Park KS. Autocrine İnsulin İncreases plasma membrane K(ATP) channel via PI3K-VAMP2 pathway in MIN6 cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):752-7.
  • 1) Kurtz I. Moleculer pathogenesis of Bartter’s syndromes. Kıdney Int 1998; 54:1396.
  • 2) Simon DB, Nelson-Williams C, Bia MJ, et al.,Gitelman’s variant of Bartter’s syndrome, inherited hypokakaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.,24.,1996,12
  • 3) Monnens L, Bındels R, Grünfeld JP.,Gitelman syndrome comes of age.,1617,1998,13
  • 7) Stein JH.,The pathogenetic spectrum of Bartter’s syndrome.,85,1985,28
Year 2017, Volume: 4 Issue: 2, 18 - 22, 28.02.2017
https://doi.org/10.17546/msd.292428

Abstract

References

  • 4) Bettinelli A, Bianchetti MG, Girardin E, et al. Use of calcıum excretion values tı distinguish two forms of primary renal tubuler hypokalemic alkalosis: Bartter and Gitelman syndromes. J Pediatr 1992; 120:38.
  • 5) Cruz DN, Shaer AJ, Bia MJ, et al. Gitelman’s syndrome revisited: an evaluation of symptoms and health related quality of life. Kıdney Int 2001;59:710.
  • 6) Cruz DN, Simon DB, Nelson-Williams C, et al. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 2001; 37:1458.
  • 8) Sann L, David L, Bernheim J, François R. Hypophosphatemia and hyperparathyroidism in a case of Bartter’s syndrome. Helv Pediatr Acta 1978; 33:299
  • 9) Bettinelli A, Vigano C, Provero MC, et al. Phosphate homeostasis in Bartter syndrome: a case-control study. Pediatr Nephrol 2014; 29:2133.
  • 10) Riveira-Munoz E, Chang Q, Godefroid N, et al. Transcriptional and functional analyses of SLC12A3 mutations: new ckues for the pathogenesis of Gitelman syndrome. J Am Soc Nephrol 2007; 18:1271.
  • 1) Flyvbjerg A, Dorup I, Everts ME, Orskow H. Evidence that potassium deficiency induces growth retardation through reduced circulating levels of growth hormone ad insulin like growth factor I. Metabolism 1991;40:769-75.
  • 2) Gil-Pena H, Garcia-Lopez E, Alvares-Garcia O, Loredo V, Carbajo-Perez E, Ordonez FA, et al. Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth hormone treatment. Am J Physiol Renal Phsiol 2009;297:F639-45.
  • 3) Ruvalcaba RH, Martinez FE. Case report: familial growth hormone deficiency associated with Bartter’s syndrome. Am J Med Sci 1992;303:411-4.
  • 4) Buyukcelik M, Keskin M, Kilic BD, Kor Y, Balat A, Bartter syndrome and growth hormone deficiency: three cases. Pediatr Nephrol 2012;27:2145-8.
  • 6) Hong R, Ling Q, WeiMing W, Jun M, Wen Z, Ping YS, Hao S, Xiao L, Nan C. Abnormal Glucose Metabolism and Insulin Sensivity in Chinese Patients with Gitelman Syndrome. Am J Nephrol 2013;37:152-157.
  • 7) Xu S, Kim JH, Hwang KH, Das R, Quan X, Nguyen TT, Kim SJ, Cha SK, Park KS. Autocrine İnsulin İncreases plasma membrane K(ATP) channel via PI3K-VAMP2 pathway in MIN6 cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):752-7.
  • 1) Kurtz I. Moleculer pathogenesis of Bartter’s syndromes. Kıdney Int 1998; 54:1396.
  • 2) Simon DB, Nelson-Williams C, Bia MJ, et al.,Gitelman’s variant of Bartter’s syndrome, inherited hypokakaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.,24.,1996,12
  • 3) Monnens L, Bındels R, Grünfeld JP.,Gitelman syndrome comes of age.,1617,1998,13
  • 7) Stein JH.,The pathogenetic spectrum of Bartter’s syndrome.,85,1985,28
There are 16 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Reports
Authors

Zeynel Abidin Sayiner

Burak Okyar This is me

Ayten Eraydin This is me

Mesut Ozkaya This is me

Publication Date February 28, 2017
Published in Issue Year 2017 Volume: 4 Issue: 2

Cite

APA Sayiner, Z. A., Okyar, B., Eraydin, A., Ozkaya, M. (2017). Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome. Medical Science and Discovery, 4(2), 18-22. https://doi.org/10.17546/msd.292428
AMA Sayiner ZA, Okyar B, Eraydin A, Ozkaya M. Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome. Med Sci Discov. February 2017;4(2):18-22. doi:10.17546/msd.292428
Chicago Sayiner, Zeynel Abidin, Burak Okyar, Ayten Eraydin, and Mesut Ozkaya. “Unusual Suspects of Secondary Diabetes and Growth Retardation: Bartter and Gitelman Syndrome”. Medical Science and Discovery 4, no. 2 (February 2017): 18-22. https://doi.org/10.17546/msd.292428.
EndNote Sayiner ZA, Okyar B, Eraydin A, Ozkaya M (February 1, 2017) Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome. Medical Science and Discovery 4 2 18–22.
IEEE Z. A. Sayiner, B. Okyar, A. Eraydin, and M. Ozkaya, “Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome”, Med Sci Discov, vol. 4, no. 2, pp. 18–22, 2017, doi: 10.17546/msd.292428.
ISNAD Sayiner, Zeynel Abidin et al. “Unusual Suspects of Secondary Diabetes and Growth Retardation: Bartter and Gitelman Syndrome”. Medical Science and Discovery 4/2 (February 2017), 18-22. https://doi.org/10.17546/msd.292428.
JAMA Sayiner ZA, Okyar B, Eraydin A, Ozkaya M. Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome. Med Sci Discov. 2017;4:18–22.
MLA Sayiner, Zeynel Abidin et al. “Unusual Suspects of Secondary Diabetes and Growth Retardation: Bartter and Gitelman Syndrome”. Medical Science and Discovery, vol. 4, no. 2, 2017, pp. 18-22, doi:10.17546/msd.292428.
Vancouver Sayiner ZA, Okyar B, Eraydin A, Ozkaya M. Unusual suspects of secondary diabetes and growth retardation: Bartter and Gitelman syndrome. Med Sci Discov. 2017;4(2):18-22.