Pattern of chronic myeloid leukemia in the Congo

Year 2017, Volume: 4 Issue: 4, 30 - 34, 30.04.2017

Lydie Ngolet , Felix Malanda Alexis Dokekias

https://doi.org/10.17546/msd.305383

Abstract

Objectives: Chronic myeloid leukemia is a clonal myeloproliférative disorder caused
by reciprocal translocation t (9;22)  that
induces tyrosin kinase protein. Imatinib is a selective inhibitor of this
protein. Aim of this study is to describe, the clinical and biological feature
of chronic myeloid leukemia in the Congo.

Material and Methods: The study is a retrospective study which conducted in
Clinical Hematology unit of teaching hospital in Brazzaville, Congo on newly
diagnosed patients with chronic myeloid leukemia. A total of 25 males and 14
females with a mean age of 36 years (16 and 69 years) at time of the diagnosis
were enrolled in the study.

Results: The mean duration of the illness at the time of the diagnosis was 11.4
months (0.5 and 50 months). Patients presented with a splenomegaly, mean
leukocytosis rate at 168.5g/l (14.6-381 g/l), moderate anemia at 8.4 g/dl (3.1
and 12.8 g/dl) and normal platelet rate at 415.4 g/dl (164 and 998 g/l). Thirty
eight on thirty nine patients (97.43 %) presented at chronic phase             and the Sokal score was high in
46.2%. Imatinib induced complete hematologic response at 3 months in all
patients. Complete cytogenetic response was achieved in 20.51%.
The median follow up period was months. The Overall Survival was 86.6% at 26
months and Progression Free Survival was 91.8% at 12 months.

Conclusion: This meta analysis
report represents the clinical and biological pattern of chronic myeloid
leukemia in the Congo.

Keywords

chronic myeloid leukemia, pattern, Congo

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