Case Report
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Year 2019, Volume: 6 Issue: 4, 73 - 75, 30.04.2019
https://doi.org/10.17546/msd.525213

Abstract

References

  • 1. Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, editors. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clinic Proceedings; 2003: Elsevier.
  • 2. Dias NEM. Acute myeloma kidney. Kidney international. 1995;48:1347-61.
  • 3. Binder M, Rajkumar S, Ketterling R, Dispenzieri A, Lacy M, Gertz M, Buadi F, Hayman S, Hwa Y, Zeldenrust S. Occurrence and prognostic significance of cytogenetic evolution in patients with multiple myeloma. Blood cancer journal. 2016;6:3e401.
  • 4. Amare PSK, Jain H, Nikalje S, Sengar M, Menon H, Inamdar N, Subramanian P, Gujral S, Shet T, Epari S. Observation on frequency & clinico-pathological significance of various cytogenetic risk groups in multiple myeloma: an experience from India. The Indian journal of medical research. 2016;144:4536.
  • 5. Shin S-Y, Eom H-S, Sohn JY, Lee H, Park B, Joo J, Jang J-H, Lee M-N, Kim JK, Kong S-Y. Prognostic Implications of Monosomies in Patients With Multiple Myeloma. Clinical Lymphoma Myeloma and Leukemia. 2017;17:3159-64. e2.
  • 6. Govindasamy P, Pandurangan P, Tarigopula A, Mani R, C RS. Cytogenetic Abnormalities in Multiple Myeloma Patients at a Tertiary Healthcare Center in India. Asian Pac J Cancer Prev. 2019;20:1235-41.10.31557/apjcp.2019.20.1.235.
  • 7. Wang CB, Wu J, Yang K, Su M, Zhang HY, Pan YZ, Wu T, Xi R, Bai H. [Retrospective Analysis of Genetics Abnormalities in Patients with Multiple Myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:61681-7.10.7534/j.issn.1009-2137.2018.06.017.
  • 8. Shaffer LG, McGowan-Jordan J, Schmid M. ISCN 2013: an international system for human cytogenetic nomenclature (2013): Karger Medical and Scientific Publishers; 2013.
  • 9. Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Blade J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Blood. 2016;127:242955-62.10.1182/blood-2016-01-631200.
  • 10. Li S, Lim HH, Woo KS, Kim SH, Han JY. A retrospective analysis of cytogenetic alterations in patients with newly diagnosed multiple myeloma: a single center study in Korea. Blood Res. 2016;51:2122-6.10.5045/br.2016.51.2.122.
  • 11. Jekarl DW, Min C-K, Kwon A, Kim H, Chae H, Kim M, Lim J, Kim Y, Han K. Impact of genetic abnormalities on the prognoses and clinical parameters of patients with multiple myeloma. Annals of laboratory medicine. 2013;33:4248-54.
  • 12. Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and survival of multiple myeloma: Isolated and combined effects. Clinical Lymphoma Myeloma and Leukemia. 2016;16:6335-40.
  • 13. Viguié F. del(13q) in multiple myeloma. Atlas Genet Cytogenet Oncol Haematol. 2001; 5(2):123-124.
  • 14. Brigaudeau C. del(6q) in Multiple Myeloma. Atlas Genet Cytogenet Oncol Haematol. 1999; 3(1):17-18.
  • 15. Lawce H, Olson S. FISH testing for deletions of chromosome 6q21 and 6q23 in hematologic neoplastic disorders. J Assoc Genet Technol. 2009;35:4167-9.
  • 16. Bozkurt S, Okay M, Haznedaroglu I. Aggressive Clinicopathological Course of Myeloma with t(3;16) (q21;q22) Cytogenetic Abnormality. Turk J Haematol. 2019;36:162-3.10.4274/tjh.galenos.2018.2018.0049.

The novel translocation of t (1;21) in multiple myeloma with poor prognosis

Year 2019, Volume: 6 Issue: 4, 73 - 75, 30.04.2019
https://doi.org/10.17546/msd.525213

Abstract





Objective:
Multiple myeloma (MM) is characterized as the neoplastic proliferation of
plasma cells producing a monoclonal paraprotein. The aim of this paper is to
report complex karyotype that leads to a fatal clinical course in a patient
with MM.


Case:
 A 48-year-old male patient was
diagnosed as MM free lambda. The karyotype of the patient was 46, XY, t(1;21)
(p11;p11), del(3) (q25;q29), del(6) (q24;q26), t(11;14) (q13;q32), del(13)
(q14;q21) in cytogenetic evaluation. Vincristine, doxorubicin and dexamethasone
were started. The creatinine levels increased after the second course of
chemotherapy, the chemotherapy protocol was switched to bortezomib and
dexamethasone. Patient was admitted to the emergency department with
pneumonia after the second chemotherapy cycle. Despite using broad spectrum
antibiotics and oxygen support, he died after the development of sepsis
syndrome.


Conclusion:
The anomaly of t (1;21) (p11;p11), that we detected in this case was detected
in a case with MM for the first time and this anomaly has not been detected
between these breaking points in any malignancies before. Although the
prognostic impact of this unique anomaly may be unclear, further studies are
needed to evaluate the effect of cytogenetic anomalies on prognosis of multiple
myeloma.


References

  • 1. Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, editors. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clinic Proceedings; 2003: Elsevier.
  • 2. Dias NEM. Acute myeloma kidney. Kidney international. 1995;48:1347-61.
  • 3. Binder M, Rajkumar S, Ketterling R, Dispenzieri A, Lacy M, Gertz M, Buadi F, Hayman S, Hwa Y, Zeldenrust S. Occurrence and prognostic significance of cytogenetic evolution in patients with multiple myeloma. Blood cancer journal. 2016;6:3e401.
  • 4. Amare PSK, Jain H, Nikalje S, Sengar M, Menon H, Inamdar N, Subramanian P, Gujral S, Shet T, Epari S. Observation on frequency & clinico-pathological significance of various cytogenetic risk groups in multiple myeloma: an experience from India. The Indian journal of medical research. 2016;144:4536.
  • 5. Shin S-Y, Eom H-S, Sohn JY, Lee H, Park B, Joo J, Jang J-H, Lee M-N, Kim JK, Kong S-Y. Prognostic Implications of Monosomies in Patients With Multiple Myeloma. Clinical Lymphoma Myeloma and Leukemia. 2017;17:3159-64. e2.
  • 6. Govindasamy P, Pandurangan P, Tarigopula A, Mani R, C RS. Cytogenetic Abnormalities in Multiple Myeloma Patients at a Tertiary Healthcare Center in India. Asian Pac J Cancer Prev. 2019;20:1235-41.10.31557/apjcp.2019.20.1.235.
  • 7. Wang CB, Wu J, Yang K, Su M, Zhang HY, Pan YZ, Wu T, Xi R, Bai H. [Retrospective Analysis of Genetics Abnormalities in Patients with Multiple Myeloma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:61681-7.10.7534/j.issn.1009-2137.2018.06.017.
  • 8. Shaffer LG, McGowan-Jordan J, Schmid M. ISCN 2013: an international system for human cytogenetic nomenclature (2013): Karger Medical and Scientific Publishers; 2013.
  • 9. Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Blade J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R. Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Blood. 2016;127:242955-62.10.1182/blood-2016-01-631200.
  • 10. Li S, Lim HH, Woo KS, Kim SH, Han JY. A retrospective analysis of cytogenetic alterations in patients with newly diagnosed multiple myeloma: a single center study in Korea. Blood Res. 2016;51:2122-6.10.5045/br.2016.51.2.122.
  • 11. Jekarl DW, Min C-K, Kwon A, Kim H, Chae H, Kim M, Lim J, Kim Y, Han K. Impact of genetic abnormalities on the prognoses and clinical parameters of patients with multiple myeloma. Annals of laboratory medicine. 2013;33:4248-54.
  • 12. Sergentanis TN, Kastritis E, Terpos E, Dimopoulos MA, Psaltopoulou T. Cytogenetics and survival of multiple myeloma: Isolated and combined effects. Clinical Lymphoma Myeloma and Leukemia. 2016;16:6335-40.
  • 13. Viguié F. del(13q) in multiple myeloma. Atlas Genet Cytogenet Oncol Haematol. 2001; 5(2):123-124.
  • 14. Brigaudeau C. del(6q) in Multiple Myeloma. Atlas Genet Cytogenet Oncol Haematol. 1999; 3(1):17-18.
  • 15. Lawce H, Olson S. FISH testing for deletions of chromosome 6q21 and 6q23 in hematologic neoplastic disorders. J Assoc Genet Technol. 2009;35:4167-9.
  • 16. Bozkurt S, Okay M, Haznedaroglu I. Aggressive Clinicopathological Course of Myeloma with t(3;16) (q21;q22) Cytogenetic Abnormality. Turk J Haematol. 2019;36:162-3.10.4274/tjh.galenos.2018.2018.0049.
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Müfide Okay

Süreyya Bozkurt 0000-0002-1765-9894

Mehmet Özgeyik This is me 0000-0002-8510-3505

İbrahim Haznedaroğlu This is me 0000-0001-8028-9462

Publication Date April 30, 2019
Published in Issue Year 2019 Volume: 6 Issue: 4

Cite

APA Okay, M., Bozkurt, S., Özgeyik, M., Haznedaroğlu, İ. (2019). The novel translocation of t (1;21) in multiple myeloma with poor prognosis. Medical Science and Discovery, 6(4), 73-75. https://doi.org/10.17546/msd.525213
AMA Okay M, Bozkurt S, Özgeyik M, Haznedaroğlu İ. The novel translocation of t (1;21) in multiple myeloma with poor prognosis. Med Sci Discov. April 2019;6(4):73-75. doi:10.17546/msd.525213
Chicago Okay, Müfide, Süreyya Bozkurt, Mehmet Özgeyik, and İbrahim Haznedaroğlu. “The Novel Translocation of T (1;21) in Multiple Myeloma With Poor Prognosis”. Medical Science and Discovery 6, no. 4 (April 2019): 73-75. https://doi.org/10.17546/msd.525213.
EndNote Okay M, Bozkurt S, Özgeyik M, Haznedaroğlu İ (April 1, 2019) The novel translocation of t (1;21) in multiple myeloma with poor prognosis. Medical Science and Discovery 6 4 73–75.
IEEE M. Okay, S. Bozkurt, M. Özgeyik, and İ. Haznedaroğlu, “The novel translocation of t (1;21) in multiple myeloma with poor prognosis”, Med Sci Discov, vol. 6, no. 4, pp. 73–75, 2019, doi: 10.17546/msd.525213.
ISNAD Okay, Müfide et al. “The Novel Translocation of T (1;21) in Multiple Myeloma With Poor Prognosis”. Medical Science and Discovery 6/4 (April 2019), 73-75. https://doi.org/10.17546/msd.525213.
JAMA Okay M, Bozkurt S, Özgeyik M, Haznedaroğlu İ. The novel translocation of t (1;21) in multiple myeloma with poor prognosis. Med Sci Discov. 2019;6:73–75.
MLA Okay, Müfide et al. “The Novel Translocation of T (1;21) in Multiple Myeloma With Poor Prognosis”. Medical Science and Discovery, vol. 6, no. 4, 2019, pp. 73-75, doi:10.17546/msd.525213.
Vancouver Okay M, Bozkurt S, Özgeyik M, Haznedaroğlu İ. The novel translocation of t (1;21) in multiple myeloma with poor prognosis. Med Sci Discov. 2019;6(4):73-5.