Gut microbiata: underestimated or exaggerated?
Abstract
Human gastrointestinal tract contains a large diversity of commensal microorganisms, which is many times more than the human living cells. In the last decade, we had enormous number of research on the association with diseases and gut microbiota composition. There is a clear increase in the number of pathological conditions associated with dysbiosis in time. Also, the range of diseases are increased and distributed to many disciplines, non-gastrointestinal diseases are also increasingly reported. Gut microbiota has multiple functions and new applications for diagnosis and therapeutics of diseases. Probiotics are widely used in health and disease states. Probably further high quality scientific research will determine the exact place of microbiota and probiotics in human health in the future.
Keywords
References
- 1. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010;107:11971–5.
- 2. Tanaka S, Kobayashi T, Songjinda P, Tateyama A, Tsubouchi M, Kiyohara C, Shirakawa T, Sonomoto K, Nakayama J. Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota. FEMS Immunol Med Microbiol. 2009;56:80–7.
- 3. Salminen S, Gibson GR, McCartney AL, Isolauri E. Influence of mode of delivery on gut microbiota composition in seven year old children. Gut. 2004;53:1388–9.
- 4. Makino H, Kushiro A, Ishikawa E, Kubota H, Gawad A, Sakai T, Oishi K, Martin R, Ben-Amor K, Knol J, Tanaka R. Mother-to-infant transmission of intestinal bifidobacterial strains has an impact on the early development of vaginally delivered infant’s microbiota. PLoS One 2013;8:e78331.
- 5. Munyaka PM, Khafipour E, Ghia JE. External influence of early childhood establishment of gut microbiota and subsequent health implications. Front Pediatr 2014;2:109.
- 6. Sender R, Fuchs S, Milo R. Revised Estimates for the number of human and bacteria cells in the body. PLoS Biol 2016; 14: 8: e1002533.
- 7. Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 2012;9:577–589.
- 8. Oleskin AV, Shenderov BA . Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota. Microb Ecol Health Dis 2016; 27:30971.
Details
Primary Language
English
Subjects
Clinical Sciences
Journal Section
Review
Authors
Tarkan Karakan
*
Türkiye
Publication Date
October 31, 2018
Submission Date
October 30, 2018
Acceptance Date
October 31, 2018
Published in Issue
Year 2018 Volume: 1 Number: 2