Febril nötropenik hastalarda orofarengeal enfeksiyonların irdelenmesi: 335 ataklık çalışma

Year 2019, , 41 - 47, 29.06.2019

Firdevs Aksoy , İftihar Koksal

https://doi.org/10.33204/mucosa.581816

Abstract

Amaç Nötropenik hastalarda mukozit orofarenks başta olmak üzere tüm gastrointestinal sistemde oluşabilmektedir. Mukoza bütünlüğünün bozulması lokal invazyona zemin hazırlar ve önemli bir enfeksiyon odağı haline gelmesine neden olur. Bu çalışmada febril nötropenik hastalarda gelişen orofarengeal enfeksiyonların değerlendirilmesi ve oral kavite muayenesinin önemine dikkati çekmek amaçlanmıştır.

Yöntem Tersiyer bir hastanede üç yıl boyunca tanı alan hematolojik maligniteli febril nötropenik hastaların demografik verileri, atak sayısı, malignitelerin dağılımı ve gelişen orofarengeal enfeksiyonlar değerlendirildi.

Bulgular Toplam 335 atak geçiren 170 hasta çalışmaya dahil edildi. Mikrobiyolojik olarak dökümante edilen enfeksiyonlarda en sık bakteremi (n=92, %27.5) vardı. İkinci en sık enfeksiyon orofarengeal enfeksiyonlardı (n=69, %20.1).Orofarengeal enfeksiyonlardan en sık izole edilen mikroorganizma funguslardı (n=34, %49.3).

Sonuç Febril nötropenik hastaların orofarengeal enfeksiyonları lokalize ve sistemik enfeksiyona ilerleyen klinik tablolara neden olabilir. Hastaların oral kavitesinin günlük muayenesi, bakımı özenli bir şekilde yapılmalıdır. Orofarengeal floraları yakın takip edilmeli ve olası bir enfeksiyon tablosunun olduğu durumlarda buradaki floranın da kaynak olabileceği mutlaka göz önünde bulundurulmalıdır.

Keywords

febril nötropeni, orofaringeal infeksiyonlar

Evaluation of oropharyngeal infections in febrile neutropenic patients: a study of 335 episodes

Abstract

Objective In neutropenic patients, mucositis can occur in the entire gastrointestinal tract, especially in the oropharynx. Disruption of mucosal integrity provides the basis for local invasion and causes it to become an important focus of infection. The aim of this study was to draw attention to the importance of oral cavity examination and evaluation of oropharyngeal infections in patients with febrile neutropenia (FN).

Methods Demographic data, number of episodes, distribution of malignancies and developing oropharyngeal infections of febrile neutropenic patients with hematologic malignancies in a tertiary hospital over a three-year period were evaluated.

Results A total of 170 patients with 335 FN episodes were included in our study. Bacteremia was the most common microbiologically documented infection (n=92, 27.5%). the second most common infection was oropharyngeal infections (n=69, 20.1%). The most common microorganism isolated from oropharyngeal infections was fungi (n=34, 49.3%).

Conclusions Oropharyngeal infections of febrile neutropenic patients may cause localized and systemic infections. Daily examination and care of the oral cavity of the patients should be done with care. The oropharyngeal flora should be closely monitored and it should be considered that the flora may also be a source in case of a possible infection.

Keywords

febrile neutropenia, oropharyngeal infections

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