Toxicity of glucocorticosteroids in autoimmune blistering diseases

Abstract

Glucocorticosteroids (GCs), have been the mainstay treatment for several dermatological diseases such as autoimmune

bullous diseases (AIBDs). However, they come with a great cost of GCs-associated adverse events causing

mortality and morbidity. Recently, a new measure to evaluate toxicity due to GCs’ use has been demonstrated to be

reliable.

This review aimed to summarise toxicity attributed to GCs use and give more insight about this new toxicity index.

Keywords

• adverse events,gulcocorticoid,toxicity,dermatology,autoimmune blistering diseases

Otoimmün büllöz hastalıklarda glukokortikosteroid toksisitesi

Abstract

Glukokortikoidler, otoimmün büllöz hastalıklar başta olmak üzere çeşitli dermatolojik hastalıkların temel tedavisi

olmuştur. Bununla birlikte, pek çok morbidite ve mortaliteye neden olan yan etkileri vardır. Son zamanlarda, glukokortikoidlerin kullanımına bağlı toksisiteyi değerlendirmek için yeni bir ölçüm sistemi geliştirilmiş ve güvenilir

olduğu gösterilmiştir.

Bu derleme, glukokortikoidlerin kullanımına bağlı oluşan yan etkileri özetlemeyi ve bu yeni tanıtılan toksisite indeksi

hakkında daha fazla bilgi vermeyi amaçlamaktadır.

Keywords

• glukokortikosteroid,yan etkiler,toksisite,dermatoloji,otoimmün büllöz hastalıklar

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