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Parotitis in a pemphigus vulgaris patient with widespread oral lesions: a rare or underdiagnosed condition?

Year 2021, , 23 - 26, 31.03.2021
https://doi.org/10.33204/mucosa.762556

Abstract

Parotitisis the inflammation of the parotid gland and frequently due to bacterial and viral infections, but
mechanical obstruction of parotitis ductus, Sjogren’s disease, other xerostomia etiologies, sarcoidosis, tuberculosis, oral ulcerations, and drugs can also cause parotitis though less frequently. Pemphigus vulgaris patients may theoretically be at an increased risk for parotitis and other salivary gland inflammations because of various reasons such as oral ulcers, poor oral intake, multiple drug use and other possible accompanying autoimmune diseases, however, such an association is reported rarely in literature. In this study, development of parotitis in a pemphigus vulgaris patient with widespread oral ulcers is presented and a possible association between parotitis and pemphigus is discussed.

References

  • Brook I. Diagnosis and management of parotitis. Arch Otolaryngol Head Neck Surg 1992;118:469-71.
  • Mahdiabadi FM, Nikvarz N. Captopril-induced sialadenitis in a patient with end-stage renal disease. J Res Pharm Pract 2016;5:146-8.
  • Brooks KG, Thompson DF. A review and assessment of drug-induced parotitis. Ann Pharmacother 2012; 46:1688-99.
  • Kenningham J. An unusual case of postoperative facial swelling. Anaesthesia 2000;55:601-2.
  • Capoccia L, Sbarigia E, Speziale F. Monolateral sialadenitis following iodinated contrast media administration for carotid artery stenting. Vascular 2010;18:34-6.
  • Almeida P de, Gregio A, Brancher JA, et al. Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:58-65.
  • Vinasco LG, Bares S, Sandkovsky U. Acute suppurative parotitis caused by Streptococcus pneumoniae in an HIV-infected man. BMJ Case Rep 2015; bcr2014209082
  • Bonnet U, Khalil-Boutros Y. Acute bilateral parotitis occurring during venlafaxine titration in an adolescent female with major depression. Pharmacopsychiatry 2014;47:36-8.
  • Iqbal K, Fassihi H, Setterfield JF, Groves RW. Recurrent acute bilateral facial pain and swelling in a patient with severe recalcitrant pemphigus vulgaris. Clin Exp Dermatol 2011;36:436-7.
  • Frumkin A. Low-dose aurothioglucose in pemphigus vulgaris. Isr J Med Sci 1986;22:903-5.
  • Chiu YW, Chen Y da, Hua TC, et al. Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan. Eur J Dermatol 2017;27:375-81.

Yaygın oral lezyonları olan bir pemfigus vulgaris hastasında parotit gelişmesi: nadir ya da gözden kaçan bir durum?

Year 2021, , 23 - 26, 31.03.2021
https://doi.org/10.33204/mucosa.762556

Abstract

Parotit, parotis bezinin iltihaplanması olup, sıklıkla bakteriyel ve viral enfeksiyonlar nedeniyle, daha nadir
olarak da parotis kanalının mekanik tıkanması, oral alımın bozulması, Sjögren hastalığı, diğer ağız kuruluğu
nedenleri, sarkoidoz, tüberküloz, ağız içinde ülser gelişimi ve bazı ilaçlar ile gelişebilmektedir. Pemfigus vulgaris
hastalarının ağız içi ülserleri, oral alımlarında bozulma, kullandıkları çoklu ilaçlar ve eşlik edebilecek diğer
otoimmün hastalıklar gibi çeşitli nedenlerle parotit ve diğer tükürük bezi iltihaplanmaları açısından artmış riske
sahip olabilecekleri teorik olarak beklenmesine karşın literatürde bildirilmiş birliktelik az sayıdadır. Burada,
yaygın oral ülserleri olan bir pemfigus vulgaris hastasında parotit gelişimi sunulmakta, parotit ile pemfigus
arasındaki olası ilişki tartışılmaktadır.

References

  • Brook I. Diagnosis and management of parotitis. Arch Otolaryngol Head Neck Surg 1992;118:469-71.
  • Mahdiabadi FM, Nikvarz N. Captopril-induced sialadenitis in a patient with end-stage renal disease. J Res Pharm Pract 2016;5:146-8.
  • Brooks KG, Thompson DF. A review and assessment of drug-induced parotitis. Ann Pharmacother 2012; 46:1688-99.
  • Kenningham J. An unusual case of postoperative facial swelling. Anaesthesia 2000;55:601-2.
  • Capoccia L, Sbarigia E, Speziale F. Monolateral sialadenitis following iodinated contrast media administration for carotid artery stenting. Vascular 2010;18:34-6.
  • Almeida P de, Gregio A, Brancher JA, et al. Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:58-65.
  • Vinasco LG, Bares S, Sandkovsky U. Acute suppurative parotitis caused by Streptococcus pneumoniae in an HIV-infected man. BMJ Case Rep 2015; bcr2014209082
  • Bonnet U, Khalil-Boutros Y. Acute bilateral parotitis occurring during venlafaxine titration in an adolescent female with major depression. Pharmacopsychiatry 2014;47:36-8.
  • Iqbal K, Fassihi H, Setterfield JF, Groves RW. Recurrent acute bilateral facial pain and swelling in a patient with severe recalcitrant pemphigus vulgaris. Clin Exp Dermatol 2011;36:436-7.
  • Frumkin A. Low-dose aurothioglucose in pemphigus vulgaris. Isr J Med Sci 1986;22:903-5.
  • Chiu YW, Chen Y da, Hua TC, et al. Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan. Eur J Dermatol 2017;27:375-81.
There are 11 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Reports
Authors

Züleyha Özgen This is me 0000-0002-9377-9548

Elif Comert Ozer 0000-0001-9802-2678

Dilek Seçkin 0000-0001-9145-6799

Publication Date March 31, 2021
Published in Issue Year 2021

Cite

Vancouver Özgen Z, Comert Ozer E, Seçkin D. Parotitis in a pemphigus vulgaris patient with widespread oral lesions: a rare or underdiagnosed condition?. Mucosa. 2021;4(1):23-6.