Protein nanoparticle interaction

Year 2022, Volume: 2 Issue: 2, 37 - 40, 06.12.2022

Nagihan Faydalı

Abstract

With the rapid development of nanotechnology in recent years, nanoparticles (NPs) have started to be used in the pharmaceutical industry for imaging, treatment and diagnosis. For the use of NPs in drug delivery, it is necessary to clearly determine how nanoparticle-based drugs will behave in the biological environment. After these drugs enter the biological environment, they interact rapidly with the proteins in the biological environment and forming a complex called Protein Corona (PC). The formation of the PC form affects many important events such as the adsorption and distribution of drugs, whether the drug reaches the target area, and the removal of the drug from the body. In order to design a more safety nanoparticle-based drug, the interaction of NPs with protein should be well understood, the physicochemical properties of the resulting PC form and its behavioral characteristics in the biological environment should be clearly clarified. In this review, the factors affecting the protein nanoparticle interaction and the analysis methods of the resulting PC form are briefly mentioned.

Keywords

Interaction, Nanoparticle, Nanotechnology, Protein corona

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