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The Role of Prophylaxıs for Preventıng Venous Thromboembolısm in Major Urologıcal Surgery and Nursıng Management

Year 2025, Volume: 20 Issue: 1, 51 - 63, 27.02.2025
https://doi.org/10.33719/nju1503620

Abstract

Venous thromboembolism (VTE), which includes both pulmonary embolism (PE) and deep vein thrombosis (DVT), is a common complication in major urological oncology surgery and is one of the significant causes of mortality and morbidity. Effective and quality nursing care and practices at every stage of the perioperative process, from the patient's initial clinical admission to post-discharge home care, can prevent potential complications. The most effective and easiest way to prevent VTE is to perform a proper risk assessment. Nurses providing care to patients undergoing major urological surgery should conduct a risk assessment through an effective nursing anamnesis in the preoperative period and take necessary precautions for individuals at risk for VTE. These precautions should be planned to encompass the intraoperative and postoperative periods as well. The primary reasons that increase susceptibility to VTE include the pelvic region being the focus of urological surgeries, the majority of patients being elderly, surgeries typically being performed in the lithotomy position, and the relatively extended period of postoperative immobilization. Risk classification, according to national and international guidelines, is categorized as 'high' or 'very high' risk, with prophylaxis post-discharge considered only for a subset of patients at 'very high risk.' VTE prevention is generally achieved through two main approaches: pharmacological and non-pharmacological prophylaxis. Pharmacological prophylaxis reduces the likelihood of VTE, but it is crucial to balance the risk of bleeding with the patient's experience. Therefore, this review aims to evaluate the role of prophylaxis and nursing management in preventing VTE in major urological surgical procedures.

References

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  • 2. Alberts BD, Woldu SL, Weinberg AC, et al.. Venous thromboembolism after major urologic oncology surgery: a focus on the incidence and timing of thromboembolic events after 27,455 operations. Urology; 2014; 84: 799–806. https://doi.org/10.1016/j. urology.2014.05.055.
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  • 6. Edeer AD, Comez S, Damar HT, Savci A. Prevalence and risk factors of venous thromboembolism in postoperative patients: a retrospective study. Pak J Med Sci. 2018;34(6):1539-1544. https://doi.org/10.12669/ pjms.346.16021
  • 7. Zareba P, Wu C, Agzarian J, Rodriguez D, Kearon C. Meta-analysis of randomized trials comparing combined compression and anticoagulation with either modality alone for prevention of venous thromboembolism after surgery. Br J Surg. 2014;101(9):1053-1062. https://doi. org/10.1002/bjs.9527.
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  • 10. Pridgeon S, Allchorne P, Turner B, et.al. Venous thromboembolism (VTE) prophylaxis and urological pelvic cancer surgery: a UK national audit. BJU Int. 2015; 115: 223–9. https://doi.org/10.1111/bju.12693.
  • 11. Petrozzello, D. Venous thromboembolism prevention practices during hospitalization. AORN, 2017.105(6), 7-9. https://doi.org/10.1016/j.aorn.2017.10.007.
  • 12. Hachey KJ, Hewes PD, Porter LP, et al. The Caprini venous thromboembolism risk assessment allows for the selection of post-discharge prophylactic anticoagulation in patients with resectable lung cancer. J Thorac Cardiovasc Surg. 2016; 151:37–44.e31. https://doi. org/10.1016/j.jtcvs.2015.08.039
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  • 14. Schomburg J, Krishna S, Soubra A et al. Extended outpatient chemoprophylaxis reduces venous thromboembolism after radical cystectomy. Urol Oncol. 2018; 36: 77.e9–13. https://doi.org/10.1016/j.urolonc.2018.06.007.
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  • 17. Koç B, Karatepe O, Geldigitti T, Tutal F, Karahan S,R. Venous thromboembolism prophylaxis practices in surgical clinics. Bakirkoy. 2013. 9(1):8-11. https://doi. org/10.5350/BTDMJB201309102.
  • 18. Lee JA, Grochow D, Drake D, et al. Evaluation of hospital nurses’ perceived knowledge and practices of venous thromboembolism assessment and prevention. J Vasc Nurs; 2014;32(1):18-24. https://doi.org/10.1016/j.jvn.2013.06.001.
  • 19. Wani, M., Al-Mitwalli, A., Mukherjee,S., Nabi, G., Somani, BK., Abbaraju, J., Madaan, S. Venous Thromboembolism (VTE) in Post-Prostatectomy Patients: Systematic Review and Meta-Analysis. J Clin Med. 2023 Jun; 12(12): 3979. Published online 2023 Jun 11. https://doi.org/10.3390/jcm12123979.
  • 20. Arslan V, Karacabay K. Examination of the use of evidence-based practices in preventing venous thromboembolism in surgical clinics. Turk J Cardiovasc Nurs. 2023; 14(33):17-23. https://doi.org/10.5543/khd.2022.14622.
  • 21. Kearon, C., Akl, E.A., Comerota, A.J., Prandoni, P., Bounameaux, H., Goldhaber, S.Z., Nelson, M.E., Wells, P.S., Gould, M.K., Dentali, F., Crowther, M., & Kahn, S.R. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th edition: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2 Suppl), e419S–e496S. https://doi.org/10.1378/chest.11-2301.
  • 22. Gezer N, Çam R, Arslan E, Şahin B. Surgical Nurses’ Knowledge and Practices Regarding Venous Thromboembolism. Turk J Cardiovasc Nurs. 2023;14(33):32-40. https://doi.org/10.5055/ tjcvsn.2023.0013.
  • 23. Ortel, L.T., Neumann, I., Ageno, W, , et al.. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. 13 OCTOBER 2020 x VOLUME 4, NUMBER 19. https://doi. org/10.1182/bloodadvances.2020001830.
  • 24. Kukreja JE, Levey HR, Scosyrev E. et al. Effectiveness and safety of extended-duration prophylaxis for venous thromboembolism in major urologic oncology surgery. Urol Oncol. 2015; 33: 387.e7–16. https://doi.org/10.1016/j.urolonc.2015.01.002.
  • 25. Abdullah, O., Parashar, D., Mustafa, I.J., Young, A.M. Venous Thromboembolism Rate by Treatment Modality in Patients with Bladder Cancer: A Systematic Review. Cureus. March 2022; 14(3): e22945. Published online March 8, 2022. https://doi.org/10.7759/cureus.22945.
  • 26. Saluja M, Gilling P. Venous thromboembolism prophylaxis in urology: A review. Int J Urol. 2017; 24:589–593. https://doi.org/10.1111/iju.13469.
  • 27. Guyatt, G. H., Akl, E. A., Crowther, M., Gutterman, D. D., & Schuünemann, H. J. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 2012. Chest, 141(2_suppl), e44S-e88S. https://doi.org/10.1378/chest.11-2296.
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MAJÖR ÜROLOJİK CERRAHİ GİRİŞİMLERDE VENÖZ TROMBOEMBOLİYİ ÖNLEMEDE PROFİLAKSİNİN ROLÜ VE HEMŞİRELİK YÖNETİMİ

Year 2025, Volume: 20 Issue: 1, 51 - 63, 27.02.2025
https://doi.org/10.33719/nju1503620

Abstract

Venöz tromboembolizm (VTE), hem pulmoner emboli (PE) hem de derin ven trombozu (DVT) dahil olmak üzere, büyük ürolojik onkoloji cerrahisinde yaygın bir komplikasyon olup, mortalite ve morbiditenin önemli nedenlerinden biridir. Hastanın ilk klinik başvurusundan taburculuk sonrası ev bakımına kadar perioperatif sürecin her aşamasında etkili ve kaliteli hemşirelik bakımı ve uygulamaları, olası komplikasyonları önleyebilir. VTE'yi önlemenin en etkili ve en kolay yolu, doğru bir risk değerlendirmesi yapmaktır. Büyük ürolojik cerrahi geçiren hastalara bakım veren hemşireler, preoperatif dönemde etkili bir hemşirelik anamnezi yoluyla risk değerlendirmesi yapmalı ve VTE riski taşıyan bireyler için gerekli önlemleri almalıdır. Bu önlemler, intraoperatif ve postoperatif dönemleri de kapsayacak şekilde planlanmalıdır. VTE'ye yatkınlığı artıran başlıca nedenler arasında, ürolojik cerrahilerin pelvis bölgesinde odaklanması, hastaların çoğunluğunun yaşlı olması, cerrahilerin genellikle litotomi pozisyonunda gerçekleştirilmesi ve postoperatif immobilizasyon süresinin nispeten uzun olması yer almaktadır. Ulusal ve uluslararası rehberlere göre risk sınıflandırması, 'yüksek' veya 'çok yüksek' risk olarak kategorize edilmekte olup, taburculuk sonrası profilaksi yalnızca 'çok yüksek risk' grubundaki hastaların bir alt kümesi için düşünülmektedir. VTE önlenmesi genellikle iki ana yaklaşımla sağlanır: farmakolojik ve farmakolojik olmayan profilaksi. Farmakolojik profilaksi VTE olasılığını azaltır, ancak kanama riski ile hastanın deneyimi arasında bir denge kurmak önemlidir. Bu nedenle, bu derlemenin amacı, büyük ürolojik cerrahi prosedürlerde VTE'yi önlemede profilaksi ve hemşirelik yönetiminin rolünü değerlendirmektir.

References

  • 1. Naik R, Mandal I, Hampson A, et al.. The role of extended venous thromboembolism prophylaxis for major urological cancer operations. BJU International © BJU International. 2019; 124(6):935-944. https://doi.org/10.1111/bju.14906.
  • 2. Alberts BD, Woldu SL, Weinberg AC, et al.. Venous thromboembolism after major urologic oncology surgery: a focus on the incidence and timing of thromboembolic events after 27,455 operations. Urology; 2014; 84: 799–806. https://doi.org/10.1016/j. urology.2014.05.055.
  • 3. World Cancer Research Fund International. Cancer trends. [Available from: https://www.wcrf.org/cancertrends] (2023).
  • 4. Logan, C.D., Hudnall, M.T., Schlick, C.J.R., French, D.D., Bartle, B., Vitello, D., Patel, H.D., Woldanski, L.M., MD, Abbott, D.E., Merkow, R.P., Odell, D.D., Bentrem, D.J. Venous Thromboembolism Chemoprophylaxis Adherence Rates After Major Cancer Surgery. JAMA Netw Open. September 2023; 6(9): e2335311. Published online on September 28, 2023. https://doi.org/10.1001/ jamanetworkopen.2023.35311.
  • 5. Association of Perioperative Registered Nurses (Association of Operating Room Nurses). Guideline for prevention of venous thromboembolism. In: Guidelines for Perioperative Practice. Denver, CO: AORN, Inc: 2018; 773-798. doi.org/10.1002/aorn.12146.
  • 6. Edeer AD, Comez S, Damar HT, Savci A. Prevalence and risk factors of venous thromboembolism in postoperative patients: a retrospective study. Pak J Med Sci. 2018;34(6):1539-1544. https://doi.org/10.12669/ pjms.346.16021
  • 7. Zareba P, Wu C, Agzarian J, Rodriguez D, Kearon C. Meta-analysis of randomized trials comparing combined compression and anticoagulation with either modality alone for prevention of venous thromboembolism after surgery. Br J Surg. 2014;101(9):1053-1062. https://doi. org/10.1002/bjs.9527.
  • 8. National Institute for Health and Care Excellence (NICE). Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism. NICE guideline [NG89], published date: March 2018. Available at: https://www.nice.org.uk/guida nce/ng89/chapter/Recommendations. Accessed March 2024. https://doi.org/10.3389/fphar.2018.01370.
  • 9. Tikkinen KAO, Guyatt Gordon H. The fundamental risks of venous thromboembolism and major bleeding are critical in decision-making for thromboprophylaxis. Eur Urol. 2020; 78(3):369–70. https://doi.org/10.1016/j.eururo.2020.05.032.
  • 10. Pridgeon S, Allchorne P, Turner B, et.al. Venous thromboembolism (VTE) prophylaxis and urological pelvic cancer surgery: a UK national audit. BJU Int. 2015; 115: 223–9. https://doi.org/10.1111/bju.12693.
  • 11. Petrozzello, D. Venous thromboembolism prevention practices during hospitalization. AORN, 2017.105(6), 7-9. https://doi.org/10.1016/j.aorn.2017.10.007.
  • 12. Hachey KJ, Hewes PD, Porter LP, et al. The Caprini venous thromboembolism risk assessment allows for the selection of post-discharge prophylactic anticoagulation in patients with resectable lung cancer. J Thorac Cardiovasc Surg. 2016; 151:37–44.e31. https://doi. org/10.1016/j.jtcvs.2015.08.039
  • 13. Oh H, Boo S, Lee JA. Clinical nurses’ knowledge and practice of venous thromboembolism risk assessment and prevention in South Korea: a cross‐sectional survey. J Clin Nurs. 2017; 26(3-4):427-435. https://doi.org/10.1111/jocn.13424.
  • 14. Schomburg J, Krishna S, Soubra A et al. Extended outpatient chemoprophylaxis reduces venous thromboembolism after radical cystectomy. Urol Oncol. 2018; 36: 77.e9–13. https://doi.org/10.1016/j.urolonc.2018.06.007.
  • 15. Packiam VT, Pariser JJ. Ongoing efforts to reduce perioperative morbidity of radical cystectomy: towards widespread adoption of extended-duration thromboprophylaxis. Transl Androl Urol; 2018; 7: S81– 2. https://doi.org/10.21037/tau.2018.02.02.
  • 16. Tikkinen KAO, Craigie S, Agarwal A, et al. Procedurespecific risks of thrombosis and bleeding in urological cancer surgery: systematic review and meta-analysis. Euro Urology. 2018;73: 242–251. https://doi.org/10.1016/j.eururo.2017.02.025.
  • 17. Koç B, Karatepe O, Geldigitti T, Tutal F, Karahan S,R. Venous thromboembolism prophylaxis practices in surgical clinics. Bakirkoy. 2013. 9(1):8-11. https://doi. org/10.5350/BTDMJB201309102.
  • 18. Lee JA, Grochow D, Drake D, et al. Evaluation of hospital nurses’ perceived knowledge and practices of venous thromboembolism assessment and prevention. J Vasc Nurs; 2014;32(1):18-24. https://doi.org/10.1016/j.jvn.2013.06.001.
  • 19. Wani, M., Al-Mitwalli, A., Mukherjee,S., Nabi, G., Somani, BK., Abbaraju, J., Madaan, S. Venous Thromboembolism (VTE) in Post-Prostatectomy Patients: Systematic Review and Meta-Analysis. J Clin Med. 2023 Jun; 12(12): 3979. Published online 2023 Jun 11. https://doi.org/10.3390/jcm12123979.
  • 20. Arslan V, Karacabay K. Examination of the use of evidence-based practices in preventing venous thromboembolism in surgical clinics. Turk J Cardiovasc Nurs. 2023; 14(33):17-23. https://doi.org/10.5543/khd.2022.14622.
  • 21. Kearon, C., Akl, E.A., Comerota, A.J., Prandoni, P., Bounameaux, H., Goldhaber, S.Z., Nelson, M.E., Wells, P.S., Gould, M.K., Dentali, F., Crowther, M., & Kahn, S.R. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th edition: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012, 141(2 Suppl), e419S–e496S. https://doi.org/10.1378/chest.11-2301.
  • 22. Gezer N, Çam R, Arslan E, Şahin B. Surgical Nurses’ Knowledge and Practices Regarding Venous Thromboembolism. Turk J Cardiovasc Nurs. 2023;14(33):32-40. https://doi.org/10.5055/ tjcvsn.2023.0013.
  • 23. Ortel, L.T., Neumann, I., Ageno, W, , et al.. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. 13 OCTOBER 2020 x VOLUME 4, NUMBER 19. https://doi. org/10.1182/bloodadvances.2020001830.
  • 24. Kukreja JE, Levey HR, Scosyrev E. et al. Effectiveness and safety of extended-duration prophylaxis for venous thromboembolism in major urologic oncology surgery. Urol Oncol. 2015; 33: 387.e7–16. https://doi.org/10.1016/j.urolonc.2015.01.002.
  • 25. Abdullah, O., Parashar, D., Mustafa, I.J., Young, A.M. Venous Thromboembolism Rate by Treatment Modality in Patients with Bladder Cancer: A Systematic Review. Cureus. March 2022; 14(3): e22945. Published online March 8, 2022. https://doi.org/10.7759/cureus.22945.
  • 26. Saluja M, Gilling P. Venous thromboembolism prophylaxis in urology: A review. Int J Urol. 2017; 24:589–593. https://doi.org/10.1111/iju.13469.
  • 27. Guyatt, G. H., Akl, E. A., Crowther, M., Gutterman, D. D., & Schuünemann, H. J. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 2012. Chest, 141(2_suppl), e44S-e88S. https://doi.org/10.1378/chest.11-2296.
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There are 50 citations in total.

Details

Primary Language English
Subjects Urology
Journal Section Reviews
Authors

Senem Güneş Kara

Publication Date February 27, 2025
Submission Date June 23, 2024
Acceptance Date October 22, 2024
Published in Issue Year 2025 Volume: 20 Issue: 1

Cite

Vancouver Güneş Kara S. The Role of Prophylaxıs for Preventıng Venous Thromboembolısm in Major Urologıcal Surgery and Nursıng Management. New J Urol. 2025;20(1):51-63.